Natriuretic peptide pharmacogenetics: Membrane metallo-endopeptidase (MME): Common gene sequence variation, functional characterization and degradation

• Published in: Journal of molecular and cellular cardiology Vol. 49; no. 5; pp. 864 - 874
• Main Authors: Pereira, Naveen L., Aksoy, Pinar, Moon, Irene, Peng, Yi, Redfield, Margaret M., Burnett, John C., Wieben, Eric D., Yee, Vivien C., Weinshilboum, Richard M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.11.2010
• Subjects: Animals; Atrial Natriuretic Factor - genetics; Autophagy; Base Sequence; Cardiovascular; Cercopithecus aethiops; COS Cells; Genetic Variation; Genomics; Haplotypes - genetics; Humans; Isoenzymes - genetics; Linkage Disequilibrium - genetics; Membrane metallo-endopeptidase; Models, Molecular; Molecular Chaperones - metabolism; Natriuretic peptides; Neprilysin - genetics; Neprilysin - metabolism; Pharmacogenetics; Polymorphism; Polymorphism, Single Nucleotide - genetics; Proteasome Endopeptidase Complex - metabolism; Protein Processing, Post-Translational; Sequence Analysis, DNA; Valine - genetics; Membrane metallo-endopeptidase; Pharmacogenetics; Natriuretic peptides; Polymorphism

Membrane metallo-endopeptidase (MME), also known as neutral endopeptidase 24.11 (EC 3.4.24.11), is involved in the metabolism of natriuretic peptides that play a key role in modulating cardiac structure and function. Common genetic variation in MME has not been addressed by resequencing the gene usi...