The GH/IGF-1 axis in obesity: pathophysiology and therapeutic considerations

• Published in: Nature reviews. Endocrinology Vol. 9; no. 6; pp. 346 - 356
• Main Authors: Berryman, Darlene E., Glad, Camilla A. M., List, Edward O., Johannsson, Gudmundur
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2013; Nature Publishing Group
• Subjects: 692/420; 692/699/2743/393; 692/700/565/238; Abdomen; Adipocytes; Adipose Tissue - metabolism; Body Composition - physiology; Body fat; Endocrinology; Endocrinology and Diabetes; Endokrinologi och diabetes; Extracellular matrix; Genetic aspects; Glucose; Glucose metabolism; Growth hormones; Human Growth Hormone - metabolism; Humans; Hypertension; Influence; Insulin resistance; Insulin-Like Growth Factor I - metabolism; Insulin-like growth factors; Lipids; Medicine; Medicine & Public Health; Metabolism; Musculoskeletal system; Obesity; Obesity - metabolism; Pathophysiology; Physiological aspects; Pituitary gland; review-article; Risk factors; Somatotropin; Sweden

Administration of recombinant human growth hormone (GH) or activation of endogenous GH production exhibits great potential to influence the onset and metabolic consequences of obesity; however, the clinical use of GH is not without controversy. This Review provides an introduction to the role of GH...