The GH/IGF-1 axis in obesity: pathophysiology and therapeutic considerations

Administration of recombinant human growth hormone (GH) or activation of endogenous GH production exhibits great potential to influence the onset and metabolic consequences of obesity; however, the clinical use of GH is not without controversy. This Review provides an introduction to the role of GH...

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Published inNature reviews. Endocrinology Vol. 9; no. 6; pp. 346 - 356
Main Authors Berryman, Darlene E., Glad, Camilla A. M., List, Edward O., Johannsson, Gudmundur
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.06.2013
Nature Publishing Group
Subjects
692/420
692/699/2743/393
692/700/565/238
Abdomen
Adipocytes
Adipose Tissue - metabolism
Body Composition - physiology
Body fat
Endocrinology
Endocrinology and Diabetes
Endokrinologi och diabetes
Extracellular matrix
Genetic aspects
Glucose
Glucose metabolism
Growth hormones
Human Growth Hormone - metabolism
Humans
Hypertension
Influence
Insulin resistance
Insulin-Like Growth Factor I - metabolism
Insulin-like growth factors
Lipids
Medicine
Medicine & Public Health
Metabolism
Musculoskeletal system
Obesity
Obesity - metabolism
Pathophysiology
Physiological aspects
Pituitary gland
review-article
Risk factors
Somatotropin
Sweden
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Abstract Administration of recombinant human growth hormone (GH) or activation of endogenous GH production exhibits great potential to influence the onset and metabolic consequences of obesity; however, the clinical use of GH is not without controversy. This Review provides an introduction to the role of GH in obesity and summarizes clinical and preclinical data that describe how GH can influence the obese state. Obesity has become one of the most common medical problems in developed countries, and this disorder is associated with high incidences of hypertension, dyslipidaemia, cardiovascular disease, type 2 diabetes mellitus and specific cancers. Growth hormone (GH) stimulates the production of insulin-like growth factor 1 in most tissues, and together GH and insulin-like growth factor 1 exert powerful collective actions on fat, protein and glucose metabolism. Clinical trials assessing the effects of GH treatment in patients with obesity have shown consistent reductions in total adipose tissue mass, in particular abdominal and visceral adipose tissue depots. Moreover, studies in patients with abdominal obesity demonstrate a marked effect of GH therapy on body composition and on lipid and glucose homeostasis. Therefore, administration of recombinant human GH or activation of endogenous GH production has great potential to influence the onset and metabolic consequences of obesity. However, the clinical use of GH is not without controversy, given conflicting results regarding its effects on glucose metabolism. This Review provides an introduction to the role of GH in obesity and summarizes clinical and preclinical data that describe how GH can influence the obese state. Key Points Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) signalling plays a major part in fuel metabolism and in the regulation of body composition Obesity, particularly abdominal obesity, exerts a strong negative effect on the spontaneous pulsatile secretion of GH, which has been associated with adverse metabolic complications GH administration in individuals with abdominal obesity reduces visceral and total body adipose tissue mass, as well as levels of total and LDL cholesterol Increasing the endogenous pulsatile GH secretion in individuals with obesity has metabolic effects similar to those obtained by the administration of exogenous GH but potentially with less adverse effects on glucose metabolism Mouse models with altered GH signalling provide a useful means for a comparative analysis of GH action in obesity The role of the GH/IGF-1 axis in modifying obesity must be assessed in light of newly emerging data that highlight the complexity of adipose tissue
AbstractList Obesity has become one of the most common medical problems in developed countries, and this disorder is associated with high incidences of hypertension, dyslipidaemia, cardiovascular disease, type 2 diabetes mellitus and specific cancers. Growth hormone (GH) stimulates the production of insulin-like growth factor 1 in most tissues, and together GH and insulin-like growth factor 1 exert powerful collective actions on fat, protein and glucose metabolism. Clinical trials assessing the effects of GH treatment in patients with obesity have shown consistent reductions in total adipose tissue mass, in particular abdominal and visceral adipose tissue depots. Moreover, studies in patients with abdominal obesity demonstrate a marked effect of GH therapy on body composition and on lipid and glucose homeostasis. Therefore, administration of recombinant human GH or activation of endogenous GH production has great potential to influence the onset and metabolic consequences of obesity. However, the clinical use of GH is not without controversy, given conflicting results regarding its effects on glucose metabolism. This Review provides an introduction to the role of GH in obesity and summarizes clinical and preclinical data that describe how GH can influence the obese state.
Obesity has become one of the most common medical problems in developed countries, and this disorder is associated with high incidences of hypertension, dyslipidaemia, cardiovascular disease, type 2 diabetes mellitus and specific cancers. Growth hormone (GH) stimulates the production of insulin-like growth factor 1 in most tissues, and together GH and insulin-like growth factor 1 exert powerful collective actions on fat, protein and glucose metabolism. Clinical trials assessing the effects of GH treatment in patients with obesity have shown consistent reductions in total adipose tissue mass, in particular abdominal and visceral adipose tissue depots. Moreover, studies in patients with abdominal obesity demonstrate a marked effect of GH therapy on body composition and on lipid and glucose homeostasis. Therefore, administration of recombinant human GH or activation of endogenous GH production has great potential to influence the onset and metabolic consequences of obesity. However, the clinical use of GH is not without controversy, given conflicting results regarding its effects on glucose metabolism. This Review provides an introduction to the role of GH in obesity and summarizes clinical and preclinical data that describe how GH can influence the obese state.Obesity has become one of the most common medical problems in developed countries, and this disorder is associated with high incidences of hypertension, dyslipidaemia, cardiovascular disease, type 2 diabetes mellitus and specific cancers. Growth hormone (GH) stimulates the production of insulin-like growth factor 1 in most tissues, and together GH and insulin-like growth factor 1 exert powerful collective actions on fat, protein and glucose metabolism. Clinical trials assessing the effects of GH treatment in patients with obesity have shown consistent reductions in total adipose tissue mass, in particular abdominal and visceral adipose tissue depots. Moreover, studies in patients with abdominal obesity demonstrate a marked effect of GH therapy on body composition and on lipid and glucose homeostasis. Therefore, administration of recombinant human GH or activation of endogenous GH production has great potential to influence the onset and metabolic consequences of obesity. However, the clinical use of GH is not without controversy, given conflicting results regarding its effects on glucose metabolism. This Review provides an introduction to the role of GH in obesity and summarizes clinical and preclinical data that describe how GH can influence the obese state.
Administration of recombinant human growth hormone (GH) or activation of endogenous GH production exhibits great potential to influence the onset and metabolic consequences of obesity; however, the clinical use of GH is not without controversy. This Review provides an introduction to the role of GH in obesity and summarizes clinical and preclinical data that describe how GH can influence the obese state. Obesity has become one of the most common medical problems in developed countries, and this disorder is associated with high incidences of hypertension, dyslipidaemia, cardiovascular disease, type 2 diabetes mellitus and specific cancers. Growth hormone (GH) stimulates the production of insulin-like growth factor 1 in most tissues, and together GH and insulin-like growth factor 1 exert powerful collective actions on fat, protein and glucose metabolism. Clinical trials assessing the effects of GH treatment in patients with obesity have shown consistent reductions in total adipose tissue mass, in particular abdominal and visceral adipose tissue depots. Moreover, studies in patients with abdominal obesity demonstrate a marked effect of GH therapy on body composition and on lipid and glucose homeostasis. Therefore, administration of recombinant human GH or activation of endogenous GH production has great potential to influence the onset and metabolic consequences of obesity. However, the clinical use of GH is not without controversy, given conflicting results regarding its effects on glucose metabolism. This Review provides an introduction to the role of GH in obesity and summarizes clinical and preclinical data that describe how GH can influence the obese state. Key Points Growth hormone (GH) and insulin-like growth factor 1 (IGF-1) signalling plays a major part in fuel metabolism and in the regulation of body composition Obesity, particularly abdominal obesity, exerts a strong negative effect on the spontaneous pulsatile secretion of GH, which has been associated with adverse metabolic complications GH administration in individuals with abdominal obesity reduces visceral and total body adipose tissue mass, as well as levels of total and LDL cholesterol Increasing the endogenous pulsatile GH secretion in individuals with obesity has metabolic effects similar to those obtained by the administration of exogenous GH but potentially with less adverse effects on glucose metabolism Mouse models with altered GH signalling provide a useful means for a comparative analysis of GH action in obesity The role of the GH/IGF-1 axis in modifying obesity must be assessed in light of newly emerging data that highlight the complexity of adipose tissue
Obesity has become one of the most common medical problems in developed countries, and this disorder is associated with high incidences of hypertension, dyslipidaemia, cardiovascular disease, type 2 diabetes mellitus and specific cancers. Growth hormone (GH) stimulates the production of insulin-like growth factor 1 in most tissues, and together GH and insulin-like growth factor 1 exert powerful collective actions on fat, protein and glucose metabolism. Clinical trials assessing the effects of GH treatment in patients with obesity have shown consistent reductions in total adipose tissue mass, in particular abdominal and visceral adipose tissue depots. Moreover, studies in patients with abdominal obesity demonstrate a marked effect of GH therapy on body composition and on lipid and glucose homeostasis. Therefore, administration of recombinant human GH or activation of endogenous GH production has great potential to influence the onset and metabolic consequences of obesity. However, the clinical use of GH is not without controversy, given conflicting results regarding its effects on glucose metabolism. This Review provides an introduction to the role of GH in obesity and summarizes clinical and preclinical data that describe how GH can influence the obese state. Berryman, D. E. et al. Nat. Rev. Endocrinol. 9, 346-356 (2013); published online 9 April 2013; doi: 10.1038/nrendo.2013.64
Audience Academic
Author List, Edward O.
Johannsson, Gudmundur
Berryman, Darlene E.
Glad, Camilla A. M.
Author_xml – sequence: 1
  givenname: Darlene E.
  surname: Berryman
  fullname: Berryman, Darlene E.
  organization: Edison Biotechnology Institute, Ohio University
– sequence: 2
  givenname: Camilla A. M.
  surname: Glad
  fullname: Glad, Camilla A. M.
  organization: Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital
– sequence: 3
  givenname: Edward O.
  surname: List
  fullname: List, Edward O.
  organization: Edison Biotechnology Institute, Ohio University
– sequence: 4
  givenname: Gudmundur
  surname: Johannsson
  fullname: Johannsson, Gudmundur
  email: gudmundur.johannsson@medic.gu.se
  organization: Department of Endocrinology, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sahlgrenska University Hospital
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23568441$$D View this record in MEDLINE/PubMed
https://gup.ub.gu.se/publication/187819$$DView record from Swedish Publication Index
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Snippet Administration of recombinant human growth hormone (GH) or activation of endogenous GH production exhibits great potential to influence the onset and metabolic...
Obesity has become one of the most common medical problems in developed countries, and this disorder is associated with high incidences of hypertension,...
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StartPage 346
SubjectTerms 692/420
692/699/2743/393
692/700/565/238
Abdomen
Adipocytes
Adipose Tissue - metabolism
Body Composition - physiology
Body fat
Endocrinology
Endocrinology and Diabetes
Endokrinologi och diabetes
Extracellular matrix
Genetic aspects
Glucose
Glucose metabolism
Growth hormones
Human Growth Hormone - metabolism
Humans
Hypertension
Influence
Insulin resistance
Insulin-Like Growth Factor I - metabolism
Insulin-like growth factors
Lipids
Medicine
Medicine & Public Health
Metabolism
Musculoskeletal system
Obesity
Obesity - metabolism
Pathophysiology
Physiological aspects
Pituitary gland
review-article
Risk factors
Somatotropin
Title The GH/IGF-1 axis in obesity: pathophysiology and therapeutic considerations
URI https://link.springer.com/article/10.1038/nrendo.2013.64
https://www.ncbi.nlm.nih.gov/pubmed/23568441
https://www.proquest.com/docview/1787144849
https://www.proquest.com/docview/1353986888
https://gup.ub.gu.se/publication/187819
Volume 9
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