Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 108; no. 39; pp. 16369 - 16374
• Main Authors: Wong, Carmen Chak-Lui, Gilkes, Daniele M., Zhang, Huafeng, Chen, Jasper, Wei, Hong, Chaturvedi, Pallavi, Fraley, Stephanie I., Wong, Chun-Ming, Khoo, Ui-Soon, Ng, Irene Oi-Lin, Wirtz, Denis, Semenza, Gregg L.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 27.09.2011; National Acad Sciences
• Subjects: Biological Sciences; Bone marrow; Bone marrow cells; Breast cancer; breast neoplasms; Breast Neoplasms - pathology; Cancer; Cell Line, Tumor; Cell lines; Collagen; Collagen - metabolism; Collagens; crosslinking; Family members; Female; Gene Knockdown Techniques; Humans; Hypoxia; Hypoxia-Inducible Factor 1 - genetics; Hypoxia-Inducible Factor 1 - physiology; Lungs; Metastasis; mice; Neoplasm Metastasis; Rodents; Tumors

Primary tumors facilitate metastasis by directing bone marrowderived cells (BMDCs) to colonize the lungs before the arrival of cancer cells. Here, we demonstrate that hypoxia-inducible factor 1 (HIF-1) is a critical regulator of breast cancer metastatic niche formation through induction of multiple...