Cytokine Signature in Schnitzler Syndrome: Proinflammatory Cytokine Production Associated to Th Suppression

• Published in: Frontiers in immunology Vol. 11; p. 588322
• Main Authors: Masson Regnault, Marie, Frouin, Eric, Jéru, Isabelle, Delwail, Adriana, Charreau, Sandrine, Barbarot, Sébastien, Néel, Antoine, Masseau, Agathe, Puéchal, Xavier, Kyndt, Xavier, Gayet, Stephane, Lifermann, François, Asli, Bouchra, Balguerie, Xavier, Blanchard-Delaunay, Claire, Aubin, François, Rizzi, Rita, Rongioletti, Franco, Boyé, Thierry, Gusdorf, Laurence, Bessis, Didier, Morel, Franck, Hainaut, Ewa, Lipsker, Dan, Lecron, Jean-Claude
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers 26.11.2020; Frontiers Media S.A
• Subjects: cytokines; IL-1; IL-1 antagonist; Immunology; inflammasome; Life Sciences; PBMC (peripheral blood mononuclear cells); Schnitzler syndrome; IL-1; PBMC (peripheral blood mononuclear cells); inflammasome; cytokines; Schnitzler syndrome; IL-1 antagonist; ex vivo

Schnitzler syndrome (SchS) is a rare autoinflammatory disease characterized by urticarial exanthema, bone and joint alterations, fever and monoclonal IgM gammopathy. Overactivation of the interleukin(IL)-1 system is reported, even though the exact pathophysiological pathways remain unknown. To deter...