An Extension of the Kimura Two-Parameter Model to the Natural Evolutionary Process

• Published in: Journal of Molecular Evolution Vol. 87; no. 1; pp. 60 - 67
• Main Authors: Nishimaki, Takuma, Sato, Keiko
• Format: Journal Article
• Language: English
• Published: New York Springer Science and Business Media LLC 01.01.2019; Springer US; Springer Nature B.V
• Subjects: Algorithms; Animal Genetics and Genomics; Biological evolution; Biomedical and Life Sciences; Cell Biology; Deoxyribonucleic acid; DNA; DNA Barcoding, Taxonomic; DNA, Plant; DNA, Ribosomal Spacer; Estimation; Evolution; Evolution, Molecular; Evolutionary Biology; Gene sequencing; INDEL Mutation; Interspecific; Life Sciences; Mathematical models; Microbiology; Models, Genetic; Models, Statistical; Mutation Rate; Original; Original Article; Parameters; Phylogeny; Physalis; Plant Genetics and Genomics; Plant Sciences; Ribosomal DNA; Spacer; K2P; Insertion; Deletion; Evolutionary model; Genetic difference

Accurate estimates of genetic difference are required for research in evolutionary biology. Here we extend the Kimura two-parameter (K2P) model by considering gaps (insertions and/or deletions) and introduce a new measure for estimating genetic difference between two nucleotide sequences in terms of...