Cortisol and proinflammatory cytokine profiles in type 1 (reversal) reactions of leprosy

• Published in: Immunology letters Vol. 156; no. 1-2; pp. 159 - 167
• Main Authors: Chaitanya, V.S., Lavania, M., Nigam, A., Turankar, R.P., Singh, I., Horo, I., Sengupta, U., Jadhav, R.S.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.11.2013
• Subjects: 11 β Hydroxysteriod dehydrogenase; 11-beta-Hydroxysteroid Dehydrogenase Type 1 - genetics; 11-beta-Hydroxysteroid Dehydrogenase Type 1 - immunology; 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism; 11-beta-Hydroxysteroid Dehydrogenase Type 2 - genetics; 11-beta-Hydroxysteroid Dehydrogenase Type 2 - immunology; 11-beta-Hydroxysteroid Dehydrogenase Type 2 - metabolism; 11-beta-Hydroxysteroid Dehydrogenases; Adolescent; Adult; Allergy and Immunology; biopsy; blood serum; Chemokine CXCL10 - blood; cortisol; Cytokines - blood; Cytokines - immunology; delayed hypersensitivity; Enzyme-Linked Immunosorbent Assay; enzymes; Female; gene expression; Gene Expression - immunology; genes; Glucocorticoids; Humans; Hydrocortisone - blood; Hydrocortisone - immunology; Hydrocortisone - urine; Hypersensitivity, Immediate - blood; Hypersensitivity, Immediate - immunology; Hypersensitivity, Immediate - urine; Inflammation; Inflammation Mediators - blood; Inflammation Mediators - immunology; interleukin-17; Interleukin-17 - blood; interleukin-1beta; interleukin-23; interleukin-6; Interleukin-6 - blood; interleukin-7; leprosy; Leprosy - blood; Leprosy - immunology; Leprosy - urine; Male; messenger RNA; Middle Aged; polymerase chain reaction; Proinflammatory cytokines; Reverse Transcriptase Polymerase Chain Reaction; Ridley Jopling classification; Skin - immunology; Skin - metabolism; Skin - pathology; tumor necrosis factor-alpha; Tumor Necrosis Factor-alpha - blood; Type 1 reaction; urine; Young Adult; 11 β Hydroxysteriod dehydrogenase; Inflammation; Proinflammatory cytokines; Glucocorticoids; Ridley Jopling classification; Type 1 reaction

•We observed localized under expression of 11 β HSD I mRNA in leprosy cases with T1R.•We observed localized under expression of 11 β HSD II mRNA in leprosy cases with T1R.•We identified low lesional and urinary cortisol levels in leprosy cases with T1R.•We observed negative correlation between serum...