A Big Bang model of human colorectal tumor growth

• Published in: Nature genetics Vol. 47; no. 3; pp. 209 - 216
• Main Authors: Sottoriva, Andrea, Kang, Haeyoun, Ma, Zhicheng, Graham, Trevor A, Salomon, Matthew P, Zhao, Junsong, Marjoram, Paul, Siegmund, Kimberly, Press, Michael F, Shibata, Darryl, Curtis, Christina
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.03.2015; Nature Publishing Group
• Subjects: 14/32; 14/63; 45/22; 45/23; 45/43; 45/61; 631/114/2785; 631/208/212; 692/699/67/1504/1885/1393; Agriculture; Analysis; Animal Genetics and Genomics; Biomedicine; Cancer Research; Cell Growth Processes - genetics; Cloning; Colorectal cancer; Colorectal Neoplasms - genetics; Colorectal Neoplasms - pathology; Gene Function; Gene mutations; Genetic aspects; Genetic Heterogeneity; Genomes; Health aspects; Heterogeneity; Human Genetics; Humans; Models, Biological; Models, Genetic; Mutation; Tumors; United States
• ISSN: 1061-4036; 1546-1718; 1546-1718
• DOI: 10.1038/ng.3214

Christina Curtis, Darryl Shibata and colleagues report genomic profiling of 349 individual glands sampled from 15 human colorectal tumors. They observe high within-tumor heterogeneity and mixing of subclones in distant tumor regions, supporting a model whereby tumor growth occurs predominantly as a...