Serum miR-1228-3p and miR-181a-5p as Noninvasive Biomarkers for Non-Small Cell Lung Cancer Diagnosis and Prognosis

• Published in: BioMed research international Vol. 2020; no. 2020; pp. 1 - 13
• Main Authors: Yin, Yunhong, Liu, Xiao, Li, Rui, Zhang, Mengyu, Xue, Wei-Xiao, Qu, Yi-Qing
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc
• Subjects: Bioinformatics; Biomarkers; Biomarkers, Tumor - blood; Cancer therapies; Carcinoma, Non-Small-Cell Lung - blood; Carcinoma, Non-Small-Cell Lung - genetics; Computational Biology - methods; Confidence intervals; Diagnosis; Down-Regulation - genetics; Female; Gene expression; Gene Expression Profiling - methods; Genes; Health aspects; Humans; Lung cancer; Lung cancer, Non-small cell; Lung Neoplasms - blood; Lung Neoplasms - genetics; Male; Medical prognosis; MicroRNA; MicroRNAs; MicroRNAs - blood; MicroRNAs - genetics; Middle Aged; miRNA; Non-small cell lung carcinoma; Patients; Polymerase chain reaction; Prognosis; Regression analysis; Reverse transcription; ROC Curve; Small cell lung carcinoma; Statistical analysis; Studies; Up-Regulation - genetics; Taiwan; United States > US; China

Background. Lung cancer is the leading cause of cancer-related mortality worldwide, and non-small cell lung cancer (NSCLC) accounts for over 80% of all lung cancers. Serum microRNAs (miRNAs), due to their high stability, have the potential to become valuable noninvasive biomarkers. This present stud...