Elevated tricuspid regurgitation velocity and decline in exercise capacity over 22 months of follow up in children and adolescents with sickle cell anemia

• Published in: Haematologica (Roma) Vol. 96; no. 1; pp. 33 - 40
• Main Authors: GORDEUK, Victor R, MINNITI, Caterina P, KATO, Gregory J, GLADWIN, Mark T, CASTRO, Oswaldo L, NOURAIE, Mehdi, CAMPBELL, Andrew D, RANA, Sohail R, LUCHTMAN-JONES, Lori, SABLE, Craig, DHAM, Niti, ENSING, Gregory, PRCHAL, Josef T
• Format: Journal Article
• Language: English
• Published: Pavia Ferrata Storti Foundation 01.01.2011
• Subjects: Adolescent; Adult; Anemia, Sickle Cell - complications; Anemia, Sickle Cell - physiopathology; Anemias. Hemoglobinopathies; Biological and medical sciences; Cardiology. Vascular system; Child; Child, Preschool; Diseases of red blood cells; Echocardiography; Endocardial and cardiac valvular diseases; Exercise; Female; Follow-Up Studies; Heart; Hematologic and hematopoietic diseases; Hemolysis; Humans; Male; Medical sciences; Mitral Valve Insufficiency; Original; Prospective Studies; Tricuspid Valve Insufficiency - etiology; Tricuspid Valve Insufficiency - physiopathology; Young Adult; Human; Physical exercise; Hemolysis; Hemoglobinopathy; tricuspid regurgitation velocity; Sickle cell anemia; Hematology; six minute walk; Cardiovascular disease; Hemopathy; E/Etdi; Tricuspid regurgitation; Velocity; Genetic disease; Hemolytic anemia; Cardiac valvular disease; Follow up study; Adolescent; Tricuspid valve; Child

While in adults with sickle cell disease an elevation of tricuspid regurgitation velocity is associated with increased mortality, the importance of this finding in children has not been established. The role of intravascular hemolysis in the development of this complication is controversial. We cond...