Recent developments on PET radiotracers for TSPO and their applications in neuroimaging - Zhang, Lingling; Hu, Kuan; Shao, Tuo; Hou, Lu; Zhang, Shaojuan; Ye, Weijian; Josephson, Lee; Meyer, Jeffrey H.; Zhang, Ming-Rong; Vasdev, Neil; Wang, Jinghao; Xu, Hao; et al. (Acta pharmaceutica Sinica. B, 2021)
Keywords: CNS disorders; Microglial activation; Neuroinflammation; Positron emission tomography (PET); Review; TSPO; AMPA; BBB; ALS; MDD; dMCAO; RCYs; QA; TSPO; TBI; BPND; HSE; NAA/Cr; PBR; AD; BcTSPO; MS; PKA; IMM; fP; EP; PSP; OMM; MAB; PCA; TBAH; SUV; FTD; ROS; SUVR; CNS disorders; DLB; PRAX-1; SAH; PAP7; VT; RRMS; BMSC; CBD; MRI; SAR; ANT; CNS; Am; TLE; BP; CRAC; LPS; P2X7R; SA; SNL; PDD; d.c. RCYs; KA; MMSE; SNR; MSA; Microglial activation; Positron emission tomography (PET); HAB; Neuroinflammation; PpIX; p.i; MAO-B; LAB; n.d.c. RCYs; OCD; MCI; PD; VDAC; HD; PET; SCIDY; Am, molar activities; DLB, Lewy body dementias; RCYs, radiochemical yields; fP, plasma free fraction; MCI, mild cognitive impairment; SA, specific activity; PDD, PD dementia; SCIDY, spirocyclic iodonium ylide; SAR, structure–activity relationship; CRAC, cholesterol recognition amino acid consensus sequence; HSE, herpes simplex encephalitis; MAB, mixed-affinity binding; NAA/Cr, N-acetylaspartate/creatine; MMSE, mini-mental state examination; PAP7, RIa-associated protein; PBR, peripheral benzodiazepine receptor; SNL, selective neuronal loss; p.i., post-injection; HAB, high-affinity binding; OMM, outer mitochondrial membrane; PET, positron emission tomography; IMM, inner mitochondrial membrane