High-fat diet, muscular lipotoxicity and insulin resistance

• Published in: Proceedings of the Nutrition Society Vol. 66; no. 1; pp. 33 - 41
• Main Author: Schrauwen, Patrick
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Cambridge, UK Cambridge University Press 01.02.2007; Cambridge Univesity Press
• Subjects: Adaptation; Adipose Tissue; Adipose Tissue - metabolism; administration & dosage; Biological and medical sciences; Body fat; body fat distribution; Carbohydrates; Cardiac muscle; chemistry; Damage; Diabetes; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 2; Diabetes Mellitus, Type 2 - etiology; Diabetes Mellitus, Type 2 - metabolism; Diet; dietary fat; Dietary Fats; Dietary Fats - administration & dosage; Dietary intake; DNA damage; Energy; Energy sources; etiology; Exercise; Exercise - physiology; fat intake; Fatty acids; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; Glucose; High fat diet; Humans; Insulin; Insulin Resistance; Lipid Metabolism; Lipid peroxidation; Lipids; literature reviews; Liver; Low fat diet; metabolism; Mitochondria; Mitochondria, Muscle; Mitochondria, Muscle - metabolism; Mitochondrial DNA; Muscle, Skeletal; Muscle, Skeletal - chemistry; Muscle, Skeletal - metabolism; Muscles; noninsulin-dependent diabetes mellitus; Obesity; Oils & fats; Overweight; Oxidation; Peroxidation; Peroxides; Peroxisome proliferator-activated receptors; Physical activity; physiology; Plasma; Proteins; Reactive oxygen species; toxicity; Vertebrates: anatomy and physiology, studies on body, several organs or systems; United States > US; Type 2 diabetes; Insulin resistance; Mitochondrial function; Oxidative damage; Intramyocellular lipids; Endocrinopathy; Intramyocellular lipids: Mitochondrial function: Oxidative damage: Type 2 diabetes: Insulin resistance; Vertebrata; Mitochondria; Mammalia; Diet; Fat; Metabolic diseases; Lipids; Feeding

A high dietary fat intake and low physical activity characterize the current Western lifestyle. Dietary fatty acids do not stimulate their own oxidation and a surplus of fat is stored in white adipose tissue, liver, heart and muscle. In these organs intracellular lipids serve as a rapidly-available...