Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 107; no. 51; pp. 22231 - 22236
• Main Authors: Fedele, Clare G., Ooms, Lisa M., Ho, Miriel, Vieusseux, Jessica, O'Toole, Sandra A., Millar, Ewan K., Lopez-Knowles, Elena, Sriratana, Absorn, Gurung, Rajendra, Baglietto, Laura, Giles, Graham G., Bailey, Charles G., Rasko, John E. J., Shields, Benjamin J., Price, John T., Majerus, Philip W., Sutherland, Robert L., Tiganis, Tony, McLean, Catriona A., Mitchell, Christina A.
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 21.12.2010; National Acad Sciences
• Subjects: Animals; Biological Sciences; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Breast cancer; breast neoplasms; Breast Neoplasms - enzymology; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Breasts; Cancer; Carcinoma; Cell growth; Cell lines; cell proliferation; Epithelial cells; epithelium; estrogen receptors; Estrogens; Female; Gene expression; Gene Expression Regulation, Enzymologic - genetics; Gene Expression Regulation, Neoplastic - genetics; heterozygosity; Human subjects; Humans; inositols; Kinases; Loss of Heterozygosity; mammary glands; Mice; Mice, Inbred BALB C; Mice, Nude; neoplasm cells; Neoplasm Transplantation; Phosphates; phosphatidylinositol 3-kinase; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; Phosphatidylinositols; Phosphoric Monoester Hydrolases - genetics; Phosphoric Monoester Hydrolases - metabolism; protein depletion; Protein synthesis; Proteins; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; PTEN Phosphohydrolase - genetics; PTEN Phosphohydrolase - metabolism; Signal Transduction; Studies; Transplantation, Heterologous; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; Tumors

Inositol polyphosphate 4-phosphatase-II (INPP4B) is a regulator of the phosphoinositide 3-kinase (PI3K) signaling pathway and is implicated as a tumor suppressor in epithelial carcinomas. INPP4B loss of heterozygosity (LOH) is detected in some human breast cancers; however, the expression of INPP4B...