Inositol polyphosphate 4-phosphatase II regulates PI3K/Akt signaling and is lost in human basal-like breast cancers - Fedele, Clare G.; Ooms, Lisa M.; Ho, Miriel; Vieusseux, Jessica; O'Toole, Sandra A.; Millar, Ewan K.; Lopez-Knowles, Elena; Sriratana, Absorn; Gurung, Rajendra; Baglietto, Laura; Giles, Graham G.; Bailey, Charles G.; et al. (Proceedings of the National Academy of Sciences - PNAS, 2010)
Keywords: Animals; Biological Sciences; Biomarkers, Tumor - genetics; Biomarkers, Tumor - metabolism; Breast cancer; breast neoplasms; Breast Neoplasms - enzymology; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Breasts; Cancer; Carcinoma; Cell growth; Cell lines; cell proliferation; Epithelial cells; epithelium; estrogen receptors; Estrogens; Female; Gene expression; Gene Expression Regulation, Enzymologic - genetics; Gene Expression Regulation, Neoplastic - genetics; heterozygosity; Human subjects; Humans; inositols; Kinases; Loss of Heterozygosity; mammary glands; Mice; Mice, Inbred BALB C; Mice, Nude; neoplasm cells; Neoplasm Transplantation; Phosphates; phosphatidylinositol 3-kinase; Phosphatidylinositol 3-Kinases - genetics; Phosphatidylinositol 3-Kinases - metabolism; Phosphatidylinositols; Phosphoric Monoester Hydrolases - genetics; Phosphoric Monoester Hydrolases - metabolism; protein depletion; Protein synthesis; Proteins; Proto-Oncogene Proteins c-akt - genetics; Proto-Oncogene Proteins c-akt - metabolism; PTEN Phosphohydrolase - genetics; PTEN Phosphohydrolase - metabolism; Signal Transduction; Studies; Transplantation, Heterologous; Tumor Suppressor Proteins - genetics; Tumor Suppressor Proteins - metabolism; Tumors