Endothelial Cell Function During Atrial Fibrillation and After Restoration of Sinus Rhythm

Beat-to-beat variation in blood flow dynamics during atrial fibrillation (AF) has been associated with evidence of endothelial dysfunction. The aim of the present work is to confirm endothelial dysfunction in patients with AF and test the hypothesis that endothelial dysfunction is reversible upon re...

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Published inThe American journal of cardiology Vol. 99; no. 9; pp. 1258 - 1262
Main Authors Skalidis, Emmanuel I., Zacharis, Evangelos A., Tsetis, Dimitrios K., Pagonidis, Kostas, Chlouverakis, Gregory, Yarmenitis, Spyridon, Hamilos, Michalis, Manios, Emmanuel G., Vardas, Panos E.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.2007
Elsevier Limited
Subjects
Aged
Atrial Fibrillation - diagnostic imaging
Atrial Fibrillation - physiopathology
Atrial Fibrillation - therapy
Brachial Artery - diagnostic imaging
Brachial Artery - physiopathology
Cardiac arrhythmia
Cardiology
Cardiovascular
Cells
Electric Countershock
Electrocardiography
Endothelial Cells - physiology
Female
Follow-Up Studies
Heart Rate - physiology
Humans
Hypotheses
Male
Middle Aged
Patients
Regional Blood Flow - physiology
Ultrasonic imaging
Ultrasonography
Vasodilation - physiology
Online AccessGet full text
ISSN0002-9149
1879-1913
DOI10.1016/j.amjcard.2006.12.044

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Abstract Beat-to-beat variation in blood flow dynamics during atrial fibrillation (AF) has been associated with evidence of endothelial dysfunction. The aim of the present work is to confirm endothelial dysfunction in patients with AF and test the hypothesis that endothelial dysfunction is reversible upon restoration of normal sinus rhythm. Endothelium-dependent (flow-mediated dilation [FMD]) and endothelium-independent (nitroglycerin-mediated dilation [NMD]) vasodilator function of the brachial artery were measured using high-resolution ultrasound in 46 patients with persistent AF who were scheduled for internal electrical cardioversion and in 25 control subjects. In patients who remained in sinus rhythm after cardioversion, these measurements were repeated after 24 hours (n = 32) and 1 month (n = 19). Compared with control subjects, patients (n = 32) showed lower FMD during AF (8.1 ± 3.6% vs 12.2 ± 3.2%, respectively, p <0.001) and similar NMD (17.0 ± 3.5% vs 15.9 ± 3.1%, respectively, p = 0.21). In 19 patients who remained in sinus rhythm, FMD increased at both 24 hours (8.0 ± 3.9% vs 10.6 ± 4.6%, p = 0.015) and 1 month (8.0 ± 3.9% vs 13.6 ± 5.3%, p <0.001). In contrast, NMD was not significantly altered at 24 hours or 1 month after sinus rhythm restoration (17.1 ± 3.9% vs 17.2 ± 4.0% vs 16.9 ± 4.1%). In conclusion, AF is associated with impairment in endothelial function that improves after sinus rhythm restoration.
AbstractList Beat-to-beat variation in blood flow dynamics during atrial fibrillation (AF) has been associated with evidence of endothelial dysfunction. The aim of the present work is to confirm endothelial dysfunction in patients with AF and test the hypothesis that endothelial dysfunction is reversible upon restoration of normal sinus rhythm. Endothelium-dependent (flow-mediated dilation [FMD]) and endothelium-independent (nitroglycerin-mediated dilation [NMD]) vasodilator function of the brachial artery were measured using high-resolution ultrasound in 46 patients with persistent AF who were scheduled for internal electrical cardioversion and in 25 control subjects. In patients who remained in sinus rhythm after cardioversion, these measurements were repeated after 24 hours (n = 32) and 1 month (n = 19). Compared with control subjects, patients (n = 32) showed lower FMD during AF (8.1 +/- 3.6% vs 12.2 +/- 3.2%, respectively, p <0.001) and similar NMD (17.0 +/- 3.5% vs 15.9 +/- 3.1%, respectively, p = 0.21). In 19 patients who remained in sinus rhythm, FMD increased at both 24 hours (8.0 +/- 3.9% vs 10.6 +/- 4.6%, p = 0.015) and 1 month (8.0 +/- 3.9% vs 13.6 +/- 5.3%, p <0.001). In contrast, NMD was not significantly altered at 24 hours or 1 month after sinus rhythm restoration (17.1 +/- 3.9% vs 17.2 +/- 4.0% vs 16.9 +/- 4.1%). In conclusion, AF is associated with impairment in endothelial function that improves after sinus rhythm restoration.
Beat-to-beat variation in blood flow dynamics during atrial fibrillation (AF) has been associated with evidence of endothelial dysfunction. The aim of the present work is to confirm endothelial dysfunction in patients with AF and test the hypothesis that endothelial dysfunction is reversible upon restoration of normal sinus rhythm. Endothelium-dependent (flow-mediated dilation [FMD]) and endothelium-independent (nitroglycerin-mediated dilation [NMD]) vasodilator function of the brachial artery were measured using high-resolution ultrasound in 46 patients with persistent AF who were scheduled for internal electrical cardioversion and in 25 control subjects. In patients who remained in sinus rhythm after cardioversion, these measurements were repeated after 24 hours (n = 32) and 1 month (n = 19). Compared with control subjects, patients (n = 32) showed lower FMD during AF (8.1 ± 3.6% vs 12.2 ± 3.2%, respectively, p <0.001) and similar NMD (17.0 ± 3.5% vs 15.9 ± 3.1%, respectively, p = 0.21). In 19 patients who remained in sinus rhythm, FMD increased at both 24 hours (8.0 ± 3.9% vs 10.6 ± 4.6%, p = 0.015) and 1 month (8.0 ± 3.9% vs 13.6 ± 5.3%, p <0.001). In contrast, NMD was not significantly altered at 24 hours or 1 month after sinus rhythm restoration (17.1 ± 3.9% vs 17.2 ± 4.0% vs 16.9 ± 4.1%). In conclusion, AF is associated with impairment in endothelial function that improves after sinus rhythm restoration.
Beat-to-beat variation in blood flow dynamics during atrial fibrillation (AF) has been associated with evidence of endothelial dysfunction. The aim of the present work is to confirm endothelial dysfunction in patients with AF and test the hypothesis that endothelial dysfunction is reversible upon restoration of normal sinus rhythm. Endothelium-dependent (flow-mediated dilation [FMD]) and endothelium-independent (nitroglycerin-mediated dilation [NMD]) vasodilator function of the brachial artery were measured using high-resolution ultrasound in 46 patients with persistent AF who were scheduled for internal electrical cardioversion and in 25 control subjects. In patients who remained in sinus rhythm after cardioversion, these measurements were repeated after 24 hours (n = 32) and 1 month (n = 19). Compared with control subjects, patients (n = 32) showed lower FMD during AF (8.1 +/- 3.6% vs 12.2 +/- 3.2%, respectively, p <0.001) and similar NMD (17.0 +/- 3.5% vs 15.9 +/- 3.1%, respectively, p = 0.21). In 19 patients who remained in sinus rhythm, FMD increased at both 24 hours (8.0 +/- 3.9% vs 10.6 +/- 4.6%, p = 0.015) and 1 month (8.0 +/- 3.9% vs 13.6 +/- 5.3%, p <0.001). In contrast, NMD was not significantly altered at 24 hours or 1 month after sinus rhythm restoration (17.1 +/- 3.9% vs 17.2 +/- 4.0% vs 16.9 +/- 4.1%). In conclusion, AF is associated with impairment in endothelial function that improves after sinus rhythm restoration.Beat-to-beat variation in blood flow dynamics during atrial fibrillation (AF) has been associated with evidence of endothelial dysfunction. The aim of the present work is to confirm endothelial dysfunction in patients with AF and test the hypothesis that endothelial dysfunction is reversible upon restoration of normal sinus rhythm. Endothelium-dependent (flow-mediated dilation [FMD]) and endothelium-independent (nitroglycerin-mediated dilation [NMD]) vasodilator function of the brachial artery were measured using high-resolution ultrasound in 46 patients with persistent AF who were scheduled for internal electrical cardioversion and in 25 control subjects. In patients who remained in sinus rhythm after cardioversion, these measurements were repeated after 24 hours (n = 32) and 1 month (n = 19). Compared with control subjects, patients (n = 32) showed lower FMD during AF (8.1 +/- 3.6% vs 12.2 +/- 3.2%, respectively, p <0.001) and similar NMD (17.0 +/- 3.5% vs 15.9 +/- 3.1%, respectively, p = 0.21). In 19 patients who remained in sinus rhythm, FMD increased at both 24 hours (8.0 +/- 3.9% vs 10.6 +/- 4.6%, p = 0.015) and 1 month (8.0 +/- 3.9% vs 13.6 +/- 5.3%, p <0.001). In contrast, NMD was not significantly altered at 24 hours or 1 month after sinus rhythm restoration (17.1 +/- 3.9% vs 17.2 +/- 4.0% vs 16.9 +/- 4.1%). In conclusion, AF is associated with impairment in endothelial function that improves after sinus rhythm restoration.
Beat-to-beat variation in blood flow dynamics during atrial fibrillation (AF) has been associated with evidence of endothelial dysfunction. The aim of the present work is to confirm endothelial dysfunction in patients with AF and test the hypothesis that endothelial dysfunction is reversible upon restoration of normal sinus rhythm. Endothelium-dependent (flow-mediated dilation [FMD]) and endothelium-independent (nitroglycerin-mediated dilation [NMD]) vasodilator function of the brachial artery were measured using high-resolution ultrasound in 46 patients with persistent AF who were scheduled for internal electrical cardioversion and in 25 control subjects. In patients who remained in sinus rhythm after cardioversion, these measurements were repeated after 24 hours (n = 32) and 1 month (n = 19). Compared with control subjects, patients (n = 32) showed lower FMD during AF (8.1 ± 3.6% vs 12.2 ± 3.2%, respectively, p <0.001) and similar NMD (17.0 ± 3.5% vs 15.9 ± 3.1%, respectively, p = 0.21). In 19 patients who remained in sinus rhythm, FMD increased at both 24 hours (8.0 ± 3.9% vs 10.6 ± 4.6%, p = 0.015) and 1 month (8.0 ± 3.9% vs 13.6 ± 5.3%, p <0.001). In contrast, NMD was not significantly altered at 24 hours or 1 month after sinus rhythm restoration (17.1 ± 3.9% vs 17.2 ± 4.0% vs 16.9 ± 4.1%). In conclusion, AF is associated with impairment in endothelial function that improves after sinus rhythm restoration. [PUBLICATION ABSTRACT]
Author Chlouverakis, Gregory
Hamilos, Michalis
Skalidis, Emmanuel I.
Vardas, Panos E.
Pagonidis, Kostas
Zacharis, Evangelos A.
Tsetis, Dimitrios K.
Yarmenitis, Spyridon
Manios, Emmanuel G.
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  fullname: Tsetis, Dimitrios K.
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/17478154$$D View this record in MEDLINE/PubMed
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Snippet Beat-to-beat variation in blood flow dynamics during atrial fibrillation (AF) has been associated with evidence of endothelial dysfunction. The aim of the...
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SubjectTerms Aged
Atrial Fibrillation - diagnostic imaging
Atrial Fibrillation - physiopathology
Atrial Fibrillation - therapy
Brachial Artery - diagnostic imaging
Brachial Artery - physiopathology
Cardiac arrhythmia
Cardiology
Cardiovascular
Cells
Electric Countershock
Electrocardiography
Endothelial Cells - physiology
Female
Follow-Up Studies
Heart Rate - physiology
Humans
Hypotheses
Male
Middle Aged
Patients
Regional Blood Flow - physiology
Ultrasonic imaging
Ultrasonography
Vasodilation - physiology
Title Endothelial Cell Function During Atrial Fibrillation and After Restoration of Sinus Rhythm
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https://www.ncbi.nlm.nih.gov/pubmed/17478154
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