A microfluidic-based neurotoxin concentration gradient for the generation of an in vitro model of Parkinson’s disease

• Published in: Biomicrofluidics Vol. 5; no. 2; pp. 022214 - 022214-14
• Main Authors: Seidi, Azadeh, Kaji, Hirokazu, Annabi, Nasim, Ostrovidov, Serge, Ramalingam, Murugan, Khademhosseini, Ali
• Format: Journal Article
• Language: English
• Published: United States American Institute of Physics 01.06.2011
• Subjects: Special Topic: Microfluidics in Cell Biology and Tissue Engineering (Guest Editor: Ali Khademhosseini)

In this study, we developed a miniaturized microfluidic-based high-throughput cell toxicity assay to create an in vitro model of Parkinson’s disease (PD). In particular, we generated concentration gradients of 6-hydroxydopamine (6-OHDA) to trigger a process of neuronal apoptosis in pheochromocytoma...