Engineering Bacillus subtilis Cells as Factories: Enzyme Secretion and Value-added Chemical Production

• Published in: Biotechnology and Bioprocess Engineering Vol. 25; no. 6; pp. 872 - 885
• Main Authors: Yoshida, Ken-ichi, van Dijl, Jan Maarten
• Format: Journal Article
• Language: English
• Published: Seoul Springer Science and Business Media LLC 01.12.2020; The Korean Society for Biotechnology and Bioengineering; Springer Nature B.V; 한국생물공학회
• Subjects: Bacillus subtilis; Bacteria; Biological research; Biology; bioprocessing; Biotechnology; Chemistry; Chemistry and Materials Science; Deoxyribonucleic acid; DNA; Engineering; Enzymes; Factories; genome; Genome editing; Genomes; Gram-positive bacteria; Health promotion; High-throughput screening; Industrial and Production Engineering; Industrial engineering; Inositol; inositols; Manufacturing engineering; Metabolic engineering; Metabolism; Metabolites; Molecular biology; multiomics; protein secretion; Proteins; R&D; Research & development; research and development; Review Paper; Secretion; Stereoisomerism; Stereoisomers; sustainable communities; synthetic biology; value added; 생물공학; enzyme; inositol; secretion; Bacillus subtilis; bioconversion

Bacillus subtilis has been studied for more than half a century, ever since the dawn of molecular biology, as a representative Gram-positive bacterium and cell factory. Two characteristic capacities of B. subtilis , namely its natural competence for DNA uptake and high-level enzyme secretion, have b...