Tick-borne flaviviruses: dissecting host immune responses and virus countermeasures

• Published in: Immunologic research Vol. 43; no. 1-3; pp. 172 - 186
• Main Authors: Robertson, Shelly J., Mitzel, Dana N., Taylor, R. Travis, Best, Sonja M., Bloom, Marshall E.
• Format: Journal Article
• Language: English
• Published: New York Humana Press Inc 2009; Springer Nature B.V
• Subjects: Allergology; Animals; Biomedical and Life Sciences; Biomedicine; Dendritic Cells - immunology; Dendritic Cells - metabolism; Dendritic Cells - virology; Disease Vectors; Encephalitis Viruses, Tick-Borne - immunology; Encephalitis Viruses, Tick-Borne - pathogenicity; Encephalitis, Tick-Borne - immunology; Encephalitis, Tick-Borne - transmission; Encephalitis, Tick-Borne - virology; Flavivirus; Humans; Immunity, Innate; Immunology; Interferon; Interferons - immunology; Interferons - metabolism; Internal Medicine; Ixodidae; Janus Kinases - immunology; Janus Kinases - metabolism; Medicine/Public Health; Neurological disorders; Parasites; Pathogens; Receptors, Pattern Recognition - immunology; Receptors, Pattern Recognition - metabolism; Signal Transduction - immunology; STAT Transcription Factors - immunology; STAT Transcription Factors - metabolism; Tick-borne encephalitis virus; Ticks - virology; Viral Envelope Proteins - immunology; Viral Envelope Proteins - metabolism; Viral Nonstructural Proteins - immunology; Viral Nonstructural Proteins - metabolism; Viral Vaccines - immunology; Viruses; tick vector; Interferon antagonism; Tick-borne flavivirus; Dendritic cells

The tick-borne encephalitis (TBE) serocomplex of viruses, genus Flavivirus , includes a number of important human pathogens that cause serious neurological illnesses and hemorrhagic fevers. These viruses pose a significant public health problem due to high rates of morbidity and mortality, their eme...