Lactotransferrin Downregulation Serves as a Potential Predictor for the Therapeutic Effectiveness of mTOR Inhibitors in the Metastatic Clear Cell Renal Cell Carcinoma without PTEN Mutation

• Published in: Biomedicines Vol. 9; no. 12; p. 1896
• Main Authors: Zheng, Jing-Quan, Lin, Che-Hsuan, Lee, Hsun-Hua, Wang, Wen-Ke, Tong, Yiu-Shun, Lee, Kang-Yun, Chiu, Hui-Wen, Lin, Yuan-Feng
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 13.12.2021; MDPI
• Subjects: AKT protein; Antibodies; Autophagy; Biomarkers; Breast cancer; Cell culture; Cell growth; Cell migration; Clear cell-type renal cell carcinoma; Cyclin-dependent kinases; Experiments; Gene set enrichment analysis; Genes; Kidney cancer; Kinases; LTF; Medical prognosis; Membranes; Metastases; Metastasis; mTOR; Multivariate analysis; Patients; Phagocytosis; Phosphorylation; Plasmids; Proteins; PTEN protein; Rapamycin; renal cell carcinoma; Software; TOR protein; United States > US; Japan; Taiwan; mTOR; renal cell carcinoma; autophagy; metastasis; LTF

Approximately 30% of clear cell renal cell carcinoma (ccRCC) patients develop metastatic spread at the first diagnosis. Therefore, identifying a useful biomarker to predict ccRCC metastasis or therapeutic effectiveness in ccRCC patients is urgently needed. Previously, we demonstrated that lactotrans...