First detection of the Africa/Caribbean/Latin American subtype of Culex flavivirus in Asian country, Taiwan

Culex flavivirus (CxFV), a member of the genus flavivirus, is a novel insect-specific flaviviruses that can be divided into two subtypes, the cytopathic Asia/U.S. and the noncytopathic Africa/Caribbean/Latin American subtypes. The CxFV circulates in several Asian countries, and here we conducted the...

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Published in	Comparative immunology, microbiology and infectious diseases Vol. 36; no. 4; pp. 387 - 396
Main Authors	Chen, Yi-Ying, Lin, Jen-Wei, Fan, Yi-Chin, Tu, Wu-Chun, Chang, Gwong-Jen J., Chiou, Shyan-Song
Format	Journal Article
Language	English
Published	England Elsevier Ltd 01.07.2013
Subjects	Allergy and Immunology Animals Base Sequence cell biology Culex Culex - virology Culex flavivirus Culex mosquitoes Flavivirus Flavivirus - classification Flavivirus - genetics Flavivirus - isolation & purification Infectious Disease Insect-only flavivirus Molecular Sequence Data Phylogeny Reverse Transcriptase Polymerase Chain Reaction RNA, Viral - chemistry RNA, Viral - genetics Sequence Alignment Sequence Analysis, DNA Taiwan Taiwan USA ASW, Caribbean Sea Asia Africa Culex mosquitoes Insect-only flavivirus Culex flavivirus
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Abstract	Culex flavivirus (CxFV), a member of the genus flavivirus, is a novel insect-specific flaviviruses that can be divided into two subtypes, the cytopathic Asia/U.S. and the noncytopathic Africa/Caribbean/Latin American subtypes. The CxFV circulates in several Asian countries, and here we conducted the first study investigating CxFV in Taiwan. A total of 14,016 mosquitoes were collected between 2010 and 2012 and 3.4% (6/179) of the pools were CxFV-positive. The phylogenetic analyses indicate that the Taiwan isolates are closely related to the Africa/Caribbean/Latin American subtype, but form an independent cluster. In the cytology experiments, the CxFV Taiwan isolate infected only mosquito cells and caused cell–cell fusion that might be associated with a unique glycine residue at position 117 within the envelope protein, which is shared with the cytopathic effect-causing Asia/US subtype. This study marks the first time the Africa/Caribbean/Latin American subtype of CxFV has been identified in an Asian country and grouped into a novel cluster.
AbstractList	Culex flavivirus (CxFV), a member of the genus flavivirus, is a novel insect-specific flaviviruses that can be divided into two subtypes, the cytopathic Asia/U.S. and the noncytopathic Africa/Caribbean/Latin American subtypes. The CxFV circulates in several Asian countries, and here we conducted the first study investigating CxFV in Taiwan. A total of 14,016 mosquitoes were collected between 2010 and 2012 and 3.4% (6/179) of the pools were CxFV-positive. The phylogenetic analyses indicate that the Taiwan isolates are closely related to the Africa/Caribbean/Latin American subtype, but form an independent cluster. In the cytology experiments, the CxFV Taiwan isolate infected only mosquito cells and caused cell–cell fusion that might be associated with a unique glycine residue at position 117 within the envelope protein, which is shared with the cytopathic effect-causing Asia/US subtype. This study marks the first time the Africa/Caribbean/Latin American subtype of CxFV has been identified in an Asian country and grouped into a novel cluster. Culex flavivirus (CxFV), a member of the genus flavivirus, is a novel insect-specific flaviviruses that can be divided into two subtypes, the cytopathic Asia/U.S. and the noncytopathic Africa/Caribbean/Latin American subtypes. The CxFV circulates in several Asian countries, and here we conducted the first study investigating CxFV in Taiwan. A total of 14,016 mosquitoes were collected between 2010 and 2012 and 3.4% (6/179) of the pools were CxFV-positive. The phylogenetic analyses indicate that the Taiwan isolates are closely related to the Africa/Caribbean/Latin American subtype, but form an independent cluster. In the cytology experiments, the CxFV Taiwan isolate infected only mosquito cells and caused cell-cell fusion that might be associated with a unique glycine residue at position 117 within the envelope protein, which is shared with the cytopathic effect-causing Asia/US subtype. This study marks the first time the Africa/Caribbean/Latin American subtype of CxFV has been identified in an Asian country and grouped into a novel cluster.Culex flavivirus (CxFV), a member of the genus flavivirus, is a novel insect-specific flaviviruses that can be divided into two subtypes, the cytopathic Asia/U.S. and the noncytopathic Africa/Caribbean/Latin American subtypes. The CxFV circulates in several Asian countries, and here we conducted the first study investigating CxFV in Taiwan. A total of 14,016 mosquitoes were collected between 2010 and 2012 and 3.4% (6/179) of the pools were CxFV-positive. The phylogenetic analyses indicate that the Taiwan isolates are closely related to the Africa/Caribbean/Latin American subtype, but form an independent cluster. In the cytology experiments, the CxFV Taiwan isolate infected only mosquito cells and caused cell-cell fusion that might be associated with a unique glycine residue at position 117 within the envelope protein, which is shared with the cytopathic effect-causing Asia/US subtype. This study marks the first time the Africa/Caribbean/Latin American subtype of CxFV has been identified in an Asian country and grouped into a novel cluster. Abstract Culex flavivirus (CxFV), a member of the genus flavivirus , is a novel insect-specific flaviviruses that can be divided into two subtypes, the cytopathic Asia/U.S. and the noncytopathic Africa/Caribbean/Latin American subtypes. The CxFV circulates in several Asian countries, and here we conducted the first study investigating CxFV in Taiwan. A total of 14,016 mosquitoes were collected between 2010 and 2012 and 3.4% (6/179) of the pools were CxFV-positive. The phylogenetic analyses indicate that the Taiwan isolates are closely related to the Africa/Caribbean/Latin American subtype, but form an independent cluster. In the cytology experiments, the CxFV Taiwan isolate infected only mosquito cells and caused cell–cell fusion that might be associated with a unique glycine residue at position 117 within the envelope protein, which is shared with the cytopathic effect-causing Asia/US subtype. This study marks the first time the Africa/Caribbean/Latin American subtype of CxFV has been identified in an Asian country and grouped into a novel cluster.
Author	Lin, Jen-Wei Chiou, Shyan-Song Fan, Yi-Chin Tu, Wu-Chun Chang, Gwong-Jen J. Chen, Yi-Ying
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Snippet	Culex flavivirus (CxFV), a member of the genus flavivirus, is a novel insect-specific flaviviruses that can be divided into two subtypes, the cytopathic... Abstract Culex flavivirus (CxFV), a member of the genus flavivirus , is a novel insect-specific flaviviruses that can be divided into two subtypes, the...
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SubjectTerms	Allergy and Immunology Animals Base Sequence cell biology Culex Culex - virology Culex flavivirus Culex mosquitoes Flavivirus Flavivirus - classification Flavivirus - genetics Flavivirus - isolation & purification Infectious Disease Insect-only flavivirus Molecular Sequence Data Phylogeny Reverse Transcriptase Polymerase Chain Reaction RNA, Viral - chemistry RNA, Viral - genetics Sequence Alignment Sequence Analysis, DNA Taiwan
Title	First detection of the Africa/Caribbean/Latin American subtype of Culex flavivirus in Asian country, Taiwan
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