CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination

• Published in: Molecular psychiatry Vol. 25; no. 6; pp. 1175 - 1190
• Main Authors: Zhang, Yuan, Du, Longfei, Bai, Ying, Han, Bing, He, Cancan, Gong, Liang, Huang, Rongrong, Shen, Ling, Chao, Jie, Liu, Pei, Zhang, Hongxing, Zhang, Haisan, Gu, Ling, Li, Junxu, Hu, Gang, Xie, Chunming, Zhang, Zhijun, Yao, Honghong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.06.2020; Nature Publishing Group
• Subjects: 13/1; 13/109; 13/21; 13/51; 14/19; 14/32; 38; 38/77; 38/90; 631/337; 631/378; 64/60; Alzheimer's disease; Analysis; Animal models; Animals; Behavioral Sciences; Biological Psychology; Central nervous system; Circular RNA; Depression, Mental; Depressive Disorder, Major - genetics; Disease Models, Animal; Heat shock proteins; Hospitals; HSP90 Heat-Shock Proteins - metabolism; Hsp90 protein; Humans; Laboratories; Lipopolysaccharides; Male; Medicine; Medicine & Public Health; Mental depression; Mental disorders; Mice; Mice, Inbred C57BL; Microglia - metabolism; MicroRNAs; MicroRNAs - genetics; miRNA; Mitogens; Neurosciences; Pathogenesis; Pathophysiology; Peripheral blood; Pharmacology; Pharmacotherapy; Psychiatry; Public health; RNA; RNA, Circular - genetics; Therapeutic applications; Type 2 diabetes; Ubiquitin; Ubiquitin-protein ligase; Ubiquitination; Ubiquitination - genetics; Zhang Yuan; China

Circular RNAs (circRNAs), highly expressed in the central nervous system, are involved in various regulatory processes and implicated in some pathophysiology. However, the potential role of circRNAs in psychiatric diseases, particularly major depressive disorder (MDD), remains largely unknown. Here,...