A maternal diet rich in fish oil may improve cardiac Akt-related signaling in the offspring of diabetic mother rats
Abstract Objective Newborns of diabetic mothers have abnormal circulatory organs, so in this study, we explore insulin signaling in the newborn rat heart. Methods Pregnant rats were divided into streptozotocin-induced diabetic groups (DM) and control groups (CM). Rats were fed lard (21% fat), fish o...
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Published in | Nutrition (Burbank, Los Angeles County, Calif.) Vol. 29; no. 4; pp. 688 - 692 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
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Elsevier Inc
01.04.2013
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Abstract | Abstract Objective Newborns of diabetic mothers have abnormal circulatory organs, so in this study, we explore insulin signaling in the newborn rat heart. Methods Pregnant rats were divided into streptozotocin-induced diabetic groups (DM) and control groups (CM). Rats were fed lard (21% fat), fish oil (21% fat), or a control diet (7% fat). To examine changes in insulin signaling in the hearts of infants of diabetic mothers (IDM) in relation to diet, we isolated the hearts from the IDM and control infants and determined the phosphorylation levels of Akt308, Akt473, p38, c-jun-NH2-terminal protein kinase (JNK), and extracellular signal-regulated protein kinase (ERK), and the expression levels of phosphoinositide-dependent protein kainase1 (PDK1) and mammalian target of rapamycin (mTOR). Results The mean blood glucose levels in the DM group and their infants were significantly higher than those in the CM group ( P < 0.05) and their infants ( P < 0.05), but the mean blood glucose levels of all infants was normal on postnatal d 4. Phosphorylation levels of AktThr 308 ( P < 0.05) and AktSer 473 and the expression levels of PDK1 and mTOR were lower in infants of diabetic mothers (IDM) than in control infants. The phosphorylation level of AktSer 473 and the expression level of mTOR increased in IDM fed the fish oil diet compared with those fed the lard diet ( P < 0.05). Conclusion A maternal diet rich in fish oil improves cardiac Akt-related signaling in the offspring of diabetic rats. |
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AbstractList | Newborns of diabetic mothers have abnormal circulatory organs, so in this study, we explore insulin signaling in the newborn rat heart.
Pregnant rats were divided into streptozotocin-induced diabetic groups (DM) and control groups (CM). Rats were fed lard (21% fat), fish oil (21% fat), or a control diet (7% fat). To examine changes in insulin signaling in the hearts of infants of diabetic mothers (IDM) in relation to diet, we isolated the hearts from the IDM and control infants and determined the phosphorylation levels of Akt308, Akt473, p38, c-jun-NH2-terminal protein kinase (JNK), and extracellular signal-regulated protein kinase (ERK), and the expression levels of phosphoinositide-dependent protein kainase1 (PDK1) and mammalian target of rapamycin (mTOR).
The mean blood glucose levels in the DM group and their infants were significantly higher than those in the CM group (P < 0.05) and their infants (P < 0.05), but the mean blood glucose levels of all infants was normal on postnatal d 4. Phosphorylation levels of Akt Thr 308 (P < 0.05) and Akt Ser 473 and the expression levels of PDK1 and mTOR were lower in infants of diabetic mothers (IDM) than in control infants. The phosphorylation level of Akt Ser 473 and the expression level of mTOR increased in IDM fed the fish oil diet compared with those fed the lard diet (P < 0.05).
A maternal diet rich in fish oil improves cardiac Akt-related signaling in the offspring of diabetic rats. Objective: Newborns of diabetic mothers have abnormal circulatory organs, so in this study, we explore insulin signaling in the newborn rat heart. Methods: Pregnant rats were divided into streptozotocin-induced diabetic groups (DM) and control groups (CM). Rats were fed lard (21% fat), fish oil (21% fat), or a control diet (7% fat). To examine changes in insulin signaling in the hearts of infants of diabetic mothers (IDM) in relation to diet, we isolated the hearts from the IDM and control infants and determined the phosphorylation levels of Akt308, Akt473, p38, c-jun-NH2-terminal protein kinase (JNK), and extracellular signal-regulated protein kinase (ERK), and the expression levels of phosphoinositide-dependent protein kainase1 (PDK1) and mammalian target of rapamycin (mTOR). Results: The mean blood glucose levels in the DM group and their infants were significantly higher than those in the CM group (P < 0.05) and their infants (P < 0.05), but the mean blood glucose levels of all infants was normal on postnatal d 4. Phosphorylation levels of Akt Thr 308 (P < 0.05) and Akt Ser 473 and the expression levels of PDK1 and mTOR were lower in infants of diabetic mothers (IDM) than in control infants. The phosphorylation level of Akt Ser 473 and the expression level of mTOR increased in IDM fed the fish oil diet compared with those fed the lard diet (P < 0.05). Conclusions: A maternal diet rich in fish oil improves cardiac Akt-related signaling in the offspring of diabetic rats. OBJECTIVENewborns of diabetic mothers have abnormal circulatory organs, so in this study, we explore insulin signaling in the newborn rat heart.METHODSPregnant rats were divided into streptozotocin-induced diabetic groups (DM) and control groups (CM). Rats were fed lard (21% fat), fish oil (21% fat), or a control diet (7% fat). To examine changes in insulin signaling in the hearts of infants of diabetic mothers (IDM) in relation to diet, we isolated the hearts from the IDM and control infants and determined the phosphorylation levels of Akt308, Akt473, p38, c-jun-NH2-terminal protein kinase (JNK), and extracellular signal-regulated protein kinase (ERK), and the expression levels of phosphoinositide-dependent protein kainase1 (PDK1) and mammalian target of rapamycin (mTOR).RESULTSThe mean blood glucose levels in the DM group and their infants were significantly higher than those in the CM group (P < 0.05) and their infants (P < 0.05), but the mean blood glucose levels of all infants was normal on postnatal d 4. Phosphorylation levels of Akt (Thr 308) (P < 0.05) and Akt (Ser 473) and the expression levels of PDK1 and mTOR were lower in infants of diabetic mothers (IDM) than in control infants. The phosphorylation level of Akt (Ser 473) and the expression level of mTOR increased in IDM fed the fish oil diet compared with those fed the lard diet (P < 0.05).CONCLUSIONA maternal diet rich in fish oil improves cardiac Akt-related signaling in the offspring of diabetic rats. Abstract Objective Newborns of diabetic mothers have abnormal circulatory organs, so in this study, we explore insulin signaling in the newborn rat heart. Methods Pregnant rats were divided into streptozotocin-induced diabetic groups (DM) and control groups (CM). Rats were fed lard (21% fat), fish oil (21% fat), or a control diet (7% fat). To examine changes in insulin signaling in the hearts of infants of diabetic mothers (IDM) in relation to diet, we isolated the hearts from the IDM and control infants and determined the phosphorylation levels of Akt308, Akt473, p38, c-jun-NH2-terminal protein kinase (JNK), and extracellular signal-regulated protein kinase (ERK), and the expression levels of phosphoinositide-dependent protein kainase1 (PDK1) and mammalian target of rapamycin (mTOR). Results The mean blood glucose levels in the DM group and their infants were significantly higher than those in the CM group ( P < 0.05) and their infants ( P < 0.05), but the mean blood glucose levels of all infants was normal on postnatal d 4. Phosphorylation levels of AktThr 308 ( P < 0.05) and AktSer 473 and the expression levels of PDK1 and mTOR were lower in infants of diabetic mothers (IDM) than in control infants. The phosphorylation level of AktSer 473 and the expression level of mTOR increased in IDM fed the fish oil diet compared with those fed the lard diet ( P < 0.05). Conclusion A maternal diet rich in fish oil improves cardiac Akt-related signaling in the offspring of diabetic rats. Objective Newborns of diabetic mothers have abnormal circulatory organs, so in this study, we explore insulin signaling in the newborn rat heart. Methods Pregnant rats were divided into streptozotocin-induced diabetic groups (DM) and control groups (CM). Rats were fed lard (21% fat), fish oil (21% fat), or a control diet (7% fat). To examine changes in insulin signaling in the hearts of infants of diabetic mothers (IDM) in relation to diet, we isolated the hearts from the IDM and control infants and determined the phosphorylation levels of Akt308, Akt473, p38, c-jun-NH2-terminal protein kinase (JNK), and extracellular signal-regulated protein kinase (ERK), and the expression levels of phosphoinositide-dependent protein kainase1 (PDK1) and mammalian target of rapamycin (mTOR). Results The mean blood glucose levels in the DM group and their infants were significantly higher than those in the CM group (P< 0.05) and their infants (P< 0.05), but the mean blood glucose levels of all infants was normal on postnatal d 4. Phosphorylation levels of AktThr 308(P< 0.05) and AktSer 473and the expression levels of PDK1 and mTOR were lower in infants of diabetic mothers (IDM) than in control infants. The phosphorylation level of AktSer 473and the expression level of mTOR increased in IDM fed the fish oil diet compared with those fed the lard diet (P< 0.05). Conclusion A maternal diet rich in fish oil improves cardiac Akt-related signaling in the offspring of diabetic rats. |
Author | Kohama, Kazuhiro, M.D., Ph.D Nasu-Kawaharada, Ritsuko, Ph.D Kakarla, Sunil K., Ph.D Nakamura, Akio, Ph.D Blough, Eric R., Ph.D Kohama, Tomoko, M.D., Ph.D |
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CitedBy_id | crossref_primary_10_1007_s00394_017_1536_6 crossref_primary_10_1093_jn_nxab403 crossref_primary_10_1016_j_rvsc_2018_01_024 crossref_primary_10_3389_fphys_2021_760251 crossref_primary_10_1530_JOE_18_0455 crossref_primary_10_1017_S000711452300017X |
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Keywords | Heart Infants MAP kinase signaling Diabetic mother Fish oil Insulin signaling Endocrinopathy Pancreatic hormone Rat Infant Signal transduction Mother Human Enzyme Transferases Diabetes mellitus Rodentia Mitogen-activated protein kinase Edible oil Insulin Feeding Vertebrata Mammalia Diet Animal Circulatory system |
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Snippet | Abstract Objective Newborns of diabetic mothers have abnormal circulatory organs, so in this study, we explore insulin signaling in the newborn rat heart.... Newborns of diabetic mothers have abnormal circulatory organs, so in this study, we explore insulin signaling in the newborn rat heart. Pregnant rats were... Objective Newborns of diabetic mothers have abnormal circulatory organs, so in this study, we explore insulin signaling in the newborn rat heart. Methods... OBJECTIVENewborns of diabetic mothers have abnormal circulatory organs, so in this study, we explore insulin signaling in the newborn rat heart.METHODSPregnant... Objective: Newborns of diabetic mothers have abnormal circulatory organs, so in this study, we explore insulin signaling in the newborn rat heart. Methods:... |
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SubjectTerms | Animals Animals, Newborn Biological and medical sciences Blood Diabetes Diabetes. Impaired glucose tolerance Diabetic mother Diet Diet, High-Fat - adverse effects Endocrine pancreas. Apud cells (diseases) Endocrinopathies Etiopathogenesis. Screening. Investigations. Target tissue resistance Feeding. Feeding behavior Female Fish oil Fish oils Fish Oils - adverse effects Fish Oils - therapeutic use Fundamental and applied biological sciences. Psychology Gastroenterology and Hepatology Glucose Heart Hyperglycemia - congenital Hyperglycemia - prevention & control Hypertriglyceridemia - complications Hypertriglyceridemia - congenital Hypertriglyceridemia - prevention & control Hypoglycemic Agents - adverse effects Hypoglycemic Agents - therapeutic use Infants Insulin Insulin signaling Kinases MAP kinase signaling MAP Kinase Signaling System Maternal Nutritional Physiological Phenomena Medical sciences Myometrium - metabolism Offspring Phosphorylation Prediabetic State - complications Prediabetic State - congenital Prediabetic State - metabolism Prediabetic State - prevention & control Pregnancy Pregnancy in Diabetics - blood Pregnancy in Diabetics - diet therapy Protein Processing, Post-Translational Proteins Proto-Oncogene Proteins c-akt - metabolism Rats Rodents Serine - metabolism Threonine - metabolism Vertebrates: anatomy and physiology, studies on body, several organs or systems |
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Title | A maternal diet rich in fish oil may improve cardiac Akt-related signaling in the offspring of diabetic mother rats |
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