Notch1 represses osteogenic pathways in aortic valve cells

• Published in: Journal of molecular and cellular cardiology Vol. 47; no. 6; pp. 828 - 834
• Main Authors: Nigam, Vishal, Srivastava, Deepak
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.12.2009
• Subjects: Animals; Aortic Valve - metabolism; Aortic Valve - pathology; Aortic valve calcification; Aortic valve interstitial cells; Bmp2; Bone Morphogenetic Protein 2 - genetics; Bone Morphogenetic Protein 2 - metabolism; Calcinosis - metabolism; Calcinosis - pathology; Cardiovascular; Cells, Cultured; Gene Expression Regulation; Gene regulation; Male; Mice; Models, Biological; Notch1; Osteoblasts - metabolism; Osteoblasts - pathology; Osteogenesis; Phenotype; Receptor, Notch1 - genetics; Receptor, Notch1 - metabolism; RNA, Messenger - genetics; RNA, Messenger - metabolism; Sheep; Signal Transduction; Bmp2; Aortic valve calcification; Aortic valve interstitial cells; Notch1; Gene regulation

Calcific aortic stenosis is the third leading cause of adult heart disease and the most common form of acquired valvular disease in developed countries. However, the molecular pathways leading to calcification are poorly understood. We reported two families in which heterozygous mutations in NOTCH1...