Enhanced and persistent antibody response against homologous and heterologous strains elicited by a MF59®-adjuvanted influenza vaccine in infants and young children

• Published in: Vaccine Vol. 32; no. 46; pp. 6146 - 6156
• Main Authors: Nolan, Terry, Bravo, Lulu, Ceballos, Ana, Mitha, Essack, Gray, Glenda, Quiambao, Beatriz, Patel, Sanjay S., Bizjajeva, Svetlana, Bock, Hans, Nazaire-Bermal, Nancy, Forleo-Neto, Eduardo, Cioppa, Giovanni Della, Narasimhan, Vas
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 21.10.2014; Elsevier; Elsevier Limited
• Subjects: (www.clinicaltrials.gov): NCT01346592; Adjuvant; Adjuvants, Immunologic - administration & dosage; Age; Allergy and Immunology; antibodies; Antibodies, Viral - blood; Antibody Formation; Applied microbiology; Biological and medical sciences; Child, Preschool; Children; Female; Fluad; Fundamental and applied biological sciences. Psychology; hemagglutination; Hemagglutination Inhibition Tests; Humans; Immunogenicity; Infant; Infants; Infections; Influenza; Influenza A Virus, H1N1 Subtype; Influenza A Virus, H3N2 Subtype; Influenza B virus; Influenza vaccine; Influenza Vaccines - administration & dosage; Influenza Vaccines - therapeutic use; Influenza, Human - prevention & control; Male; MF59; Microbiology; Polysorbates - administration & dosage; seroconversion; Single-Blind Method; Squalene - administration & dosage; subunit vaccines; vaccination; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Subunit - administration & dosage; Vaccines, Subunit - therapeutic use; Viral infections; virion; TIV; HI; AE; CI; (www.clinicaltrials.gov): NCT01346592; aTIV; GMT; PPS; MF59; FAS; Adjuvant; Children; Influenza vaccine; Fluad; full analysis set; hemagglutination inhibition; trivalent influenza vaccine; adverse event; adjuvanted trivalent influenza vaccine; geometric mean titer; per protocol set; confidence interval; Human; Immune response; Infant; Vaccine; Strain; Infection; Viral disease; Immunological adjuvant; Influenza A; Child; Humoral immunity; Fluad(®)

•Adjuvanted (aTIV) and two non-adjuvanted (TIV) vaccines compared in young children.•Enhanced antibody response to aTIV against all homologous and heterologous strains.•Significantly faster (after one dose) and more persistent response to aTIV.•aTIV increasingly superior to TIV with increasing HI th...