The Association Between the Cardio-ankle Vascular Index and Other Parameters of Vascular Structure and Function in Caucasian Adults: MARK Study
Aim: We assessed whether there is an association between the cardio-ankle vascular index (CAVI) score and the carotid intima media thickness (IMT), the pulse wave velocity (PWV) and the central augmentation index (CAIx) that is independent of the subject's cardiovascular risk and pharmacologica...
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Published in | Journal of Atherosclerosis and Thrombosis Vol. 22; no. 9; pp. 901 - 911 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Japan
Japan Atherosclerosis Society
01.01.2015
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Subjects | |
Online Access | Get full text |
ISSN | 1340-3478 1880-3873 1880-3873 |
DOI | 10.5551/jat.28035 |
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Abstract | Aim: We assessed whether there is an association between the cardio-ankle vascular index (CAVI) score and the carotid intima media thickness (IMT), the pulse wave velocity (PWV) and the central augmentation index (CAIx) that is independent of the subject's cardiovascular risk and pharmacological treatment. Methods: The CAVI score was measured in 500 subjects using a VaSera device and the brachial ankle PWV (ba-PWV) was calculated. A carotid ultrasound was used to measure the IMT. A Mobil-O-Graph device was used to measure the carotid femoral PWV (cf-PWV) and the CAIx. The Framingham-D'Agostino and SCORE scales were used to measure the subject's cardiovascular risk. Results: The mean value of the CAVI score was 8.59±1.1. IMT, CAIx and PWV maintained a positive association with the CAVI score (p<0.01) in a multiple linear regression analysis, after adjusting for the subject's cardiovascular risk, body mass index and pharmacological treatment. The cut-off level that gave the maxima sensitivity and specificity to detect a mean IMT of >0.90 mm was 8.95 (AUC=0.67) for the CAVI score, 8.85 (AUC=0.66) for cf-PWV and 15.10 (AUC=0.66) for ba-PWV. The cut-off to detect a maxima IMT of >0.90 mm was 8.60 (AUC=0.62) for the CAVI score, 8.85 (AUC=0.64) for cf-PWV and 15.75 (AUC=0.70) for ba-PWV. Conclusion: There was a positive association of the CAVI score with vascular structure and function parameters that was independent of cardiovascular risk and any medications being used by the subject. The ability of the CAVI score to predict carotid atherosclerosis is similar to that of cf-PWV and ba-PWV in Caucasian adults. |
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AbstractList | Aim: We assessed whether there is an association between the cardio-ankle vascular index (CAVI) score and the carotid intima media thickness (IMT), the pulse wave velocity (PWV) and the central augmentation index (CAIx) that is independent of the subject's cardiovascular risk and pharmacological treatment. Methods: The CAVI score was measured in 500 subjects using a VaSera device and the brachial ankle PWV (ba-PWV) was calculated. A carotid ultrasound was used to measure the IMT. A Mobil-O-Graph device was used to measure the carotid femoral PWV (cf-PWV) and the CAIx. The Framingham-D'Agostino and SCORE scales were used to measure the subject's cardiovascular risk. Results: The mean value of the CAVI score was 8.59±1.1. IMT, CAIx and PWV maintained a positive association with the CAVI score (p<0.01) in a multiple linear regression analysis, after adjusting for the subject's cardiovascular risk, body mass index and pharmacological treatment. The cut-off level that gave the maxima sensitivity and specificity to detect a mean IMT of >0.90 mm was 8.95 (AUC=0.67) for the CAVI score, 8.85 (AUC=0.66) for cf-PWV and 15.10 (AUC=0.66) for ba-PWV. The cut-off to detect a maxima IMT of >0.90 mm was 8.60 (AUC=0.62) for the CAVI score, 8.85 (AUC=0.64) for cf-PWV and 15.75 (AUC=0.70) for ba-PWV. Conclusion: There was a positive association of the CAVI score with vascular structure and function parameters that was independent of cardiovascular risk and any medications being used by the subject. The ability of the CAVI score to predict carotid atherosclerosis is similar to that of cf-PWV and ba-PWV in Caucasian adults. We assessed whether there is an association between the cardio-ankle vascular index (CAVI) score and the carotid intima media thickness (IMT), the pulse wave velocity (PWV) and the central augmentation index (CAIx) that is independent of the subject's cardiovascular risk and pharmacological treatment. The CAVI score was measured in 500 subjects using a VaSera device and the brachial ankle PWV (ba-PWV) was calculated. A carotid ultrasound was used to measure the IMT. A Mobil-O-Graph device was used to measure the carotid femoral PWV (cf-PWV) and the CAIx. The Framingham-D'Agostino and SCORE scales were used to measure the subject's cardiovascular risk. The mean value of the CAVI score was 8.59 ± 1.1. IMT, CAIx and PWV maintained a positive association with the CAVI score (p < 0.01) in a multiple linear regression analysis, after adjusting for the subject's cardiovascular risk, body mass index and pharmacological treatment. The cut-off level that gave the maxima sensitivity and specificity to detect a mean IMT of > 0.90 mm was 8.95 (AUC=0.67) for the CAVI score, 8.85 (AUC=0.66) for cf-PWV and 15.10 (AUC=0.66) for ba-PWV. The cut-off to detect a maxima IMT of > 0.90 mm was 8.60 (AUC=0.62) for the CAVI score, 8.85 (AUC=0.64) for cf-PWV and 15.75 (AUC=0.70) for ba-PWV. There was a positive association of the CAVI score with vascular structure and function parameters that was independent of cardiovascular risk and any medications being used by the subject. The ability of the CAVI score to predict carotid atherosclerosis is similar to that of cf-PWV and ba-PWV in Caucasian adults. [Aim] : We assessed whether there is an association between the cardio-ankle vascular index (CAVI) score and the carotid intima media thickness (IMT), the pulse wave velocity (PWV) and the central augmentation index (CAIx) that is independent of the subject's cardiovascular risk and pharmacological treatment. [Methods] : The CAVI score was measured in 500 subjects using a VaSera device and the brachial ankle PWV (ba-PWV) was calculated. A carotid ultrasound was used to measure the IMT. A Mobil-O-Graph device was used to measure the carotid femoral PWV (cf-PWV) and the CAIx. The Framingham-D'Agostino and SCORE scales were used to measure the subject's cardiovascular risk. [Results] : The mean value of the CAVI score was 8.59 +- 1.1. IMT, CAIx and PWV maintained a positive association with the CAVI score (p < 0.01) in a multiple linear regression analysis, after adjusting for the subject's cardiovascular risk, body mass index and pharmacological treatment. The cut-off level that gave the maxima sensitivity and specificity to detect a mean IMT of > 0.90 mm was 8.95 (AUC = 0.67) for the CAVI score, 8.85 (AUC = 0.66) for cf-PWV and 15.10 (AUC = 0.66) for ba-PWV. The cut-off to detect a maxima IMT of > 0.90 mm was 8.60 (AUC = 0.62) for the CAVI score, 8.85 (AUC = 0.64) for cf-PWV and 15.75 (AUC = 0.70) for ba-PWV. [Conclusion] : There was a positive association of the CAVI score with vascular structure and function parameters that was independent of cardiovascular risk and any medications being used by the subject. The ability of the CAVI score to predict carotid atherosclerosis is similar to that of cf-PWV and ba-PWV in Caucasian adults. We assessed whether there is an association between the cardio-ankle vascular index (CAVI) score and the carotid intima media thickness (IMT), the pulse wave velocity (PWV) and the central augmentation index (CAIx) that is independent of the subject's cardiovascular risk and pharmacological treatment.AIMWe assessed whether there is an association between the cardio-ankle vascular index (CAVI) score and the carotid intima media thickness (IMT), the pulse wave velocity (PWV) and the central augmentation index (CAIx) that is independent of the subject's cardiovascular risk and pharmacological treatment.The CAVI score was measured in 500 subjects using a VaSera device and the brachial ankle PWV (ba-PWV) was calculated. A carotid ultrasound was used to measure the IMT. A Mobil-O-Graph device was used to measure the carotid femoral PWV (cf-PWV) and the CAIx. The Framingham-D'Agostino and SCORE scales were used to measure the subject's cardiovascular risk.METHODSThe CAVI score was measured in 500 subjects using a VaSera device and the brachial ankle PWV (ba-PWV) was calculated. A carotid ultrasound was used to measure the IMT. A Mobil-O-Graph device was used to measure the carotid femoral PWV (cf-PWV) and the CAIx. The Framingham-D'Agostino and SCORE scales were used to measure the subject's cardiovascular risk.The mean value of the CAVI score was 8.59 ± 1.1. IMT, CAIx and PWV maintained a positive association with the CAVI score (p < 0.01) in a multiple linear regression analysis, after adjusting for the subject's cardiovascular risk, body mass index and pharmacological treatment. The cut-off level that gave the maxima sensitivity and specificity to detect a mean IMT of > 0.90 mm was 8.95 (AUC=0.67) for the CAVI score, 8.85 (AUC=0.66) for cf-PWV and 15.10 (AUC=0.66) for ba-PWV. The cut-off to detect a maxima IMT of > 0.90 mm was 8.60 (AUC=0.62) for the CAVI score, 8.85 (AUC=0.64) for cf-PWV and 15.75 (AUC=0.70) for ba-PWV.RESULTSThe mean value of the CAVI score was 8.59 ± 1.1. IMT, CAIx and PWV maintained a positive association with the CAVI score (p < 0.01) in a multiple linear regression analysis, after adjusting for the subject's cardiovascular risk, body mass index and pharmacological treatment. The cut-off level that gave the maxima sensitivity and specificity to detect a mean IMT of > 0.90 mm was 8.95 (AUC=0.67) for the CAVI score, 8.85 (AUC=0.66) for cf-PWV and 15.10 (AUC=0.66) for ba-PWV. The cut-off to detect a maxima IMT of > 0.90 mm was 8.60 (AUC=0.62) for the CAVI score, 8.85 (AUC=0.64) for cf-PWV and 15.75 (AUC=0.70) for ba-PWV.There was a positive association of the CAVI score with vascular structure and function parameters that was independent of cardiovascular risk and any medications being used by the subject. The ability of the CAVI score to predict carotid atherosclerosis is similar to that of cf-PWV and ba-PWV in Caucasian adults.CONCLUSIONThere was a positive association of the CAVI score with vascular structure and function parameters that was independent of cardiovascular risk and any medications being used by the subject. The ability of the CAVI score to predict carotid atherosclerosis is similar to that of cf-PWV and ba-PWV in Caucasian adults. |
Author | Martí, Ruth Agudo-Conde, Cristina Gomez-Sanchez, Leticia Frontera, Guillermo Gomez-Marcos, Manuel A Garcia-Ortiz, Luis Ramos, Rafel Maderuelo-Fernández, Jose A Patino-Alonso, Maria C Recio-Rodriguez, José I Rodriguez-Sanchez, Emiliano |
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BackLink | https://www.ncbi.nlm.nih.gov/pubmed/25994828$$D View this record in MEDLINE/PubMed |
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ContentType | Journal Article |
Contributor | Lull, Micaela Martí, Ruth Rigo, Fernando Gutierrez, Mercedes Gil, Irina Rodriguez-Martín, Carmela Gomez-Marcos, Manuel A Quesada, Miquel Sanchez-Salgado, Benigna Ramos, Rafel Rotger, Antonia Gillaumet, John Agudo-Conde, Cristina Garcia, Natividad Gomez-Sanchez, Leticia Frontera, Guillermo Montoya, Ignacio Ponjoan, Anna Garcia-Gil, Maria Feuerbach, Natalia Ramos-Delgado, Emilio de Cabo-Laso, Angela Camos, Lourdes Maderuelo-Fernandez, JoseAngel Recio-Rodriguez, Jose I Agell, Anna Pons, Susana López, Carlos Garcia-Ortiz, Luis Parramon, Dídac Rodriguez-Sanchez, Emiliano Montesinos, Fernando Sidera, Martina Gomez-Sanchez, Marta Castaño-Sancho, Carmen Patino-Alonso, Carmen |
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Copyright | 2015 Japan Atherosclerosis Society |
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References_xml | – reference: 9) Okura T, Watanabe S, Kurata M, Manabe S, Koresawa M, Irita J, Enomoto D, Miyoshi K, Fukuoka T, Higaki J: Relationship between cardio-ankle vascular index (CAVI) and carotid atherosclerosis in patients with essential hypertension. Hypertens Res, 2007; 30: 335-340 – reference: 20) Marrugat J, D'Agostino R, Sullivan L, Elosua R, Wilson P, Ordovas J, Solanas P, Cordon F, Ramos R, Sala J, Masia R, Kannel WB: An adaptation of the Framingham coronary heart disease risk function to European Mediterranean areas. J Epidemiol Community Health, 2003; 57: 634-638 – reference: 8) Izuhara M, Shioji K, Kadota S, Baba O, Takeuchi Y, Uegaito T, Mutsuo S, Matsuda M: Relationship of cardio-ankle vascular index (CAVI) to carotid and coronary arteriosclerosis. Circ J, 2008; 72: 1762-1767 – reference: 31) Protogerou AD, Argyris A, Nasothimiou E, Vrachatis D, Papaioannou TG, Tzamouranis D, Blacher J, Safar ME, Sfikakis P, Stergiou GS: Feasibility and reproducibility of noninvasive 24-h ambulatory aortic blood pressure monitoring with a brachial cuff-based oscillometric device. Am J Hypertens, 2012; 25: 876-882 – reference: 16) Mitchell GF, Hwang SJ, Vasan RS, Larson MG, Pencina MJ, Hamburg NM, Vita JA, Levy D, Benjamin EJ: Arterial stiffness and cardiovascular events: the Framingham Heart Study. Circulation, 2010; 121: 505-511 – reference: 22) World Medical Association Declaration of Helsinki: ethical principles for medical research involving human subjects. JAMA, 2013; 310: 2191-2194 – reference: 33) LM VB, Laurent S Fau - Boutouyrie P, Boutouyrie P Fau - Chowienczyk P, Chowienczyk P Fau - Cruickshank JK, Cruickshank Jk Fau - De Backer T, De Backer T Fau - Filipovsky J, Filipovsky J Fau - Huybrechts S, Huybrechts S Fau - Mattace-Raso FUS, Mattace-Raso Fu Fau - Proto gerou AD, Protogerou Ad Fau - Schillaci G, Schillaci G Fau - Segers P, Segers P Fau - Vermeersch S, Vermeersch S Fau - Weber T, T W: - Expert consensus document on the measurement of aortic stiffness in daily practice using carotid-femoral pulse wave velocity. J Hypertens, 2012; 30: 445-448 – reference: 1) Shirai K, Hiruta N, Song M, Kurosu T, Suzuki J, Tomaru T, Miyashita Y, Saiki A, Takahashi M, Suzuki K, Takata M: Cardio-ankle vascular index (CAVI) as a novel indicator of arterial stiffness: theory, evidence and perspectives. 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J Atheroscler Thromb, 2013; 20: 391-400 – reference: 32) Weiss W, Gohlisch C, Harsch-Gladisch C, Tolle M, Zidek W, van der Giet M: Oscillometric estimation of central blood pressure: validation of the Mobil-O-Graph in comparison with the SphygmoCor device. Blood Press Monit, 2012; 17: 128-131 – reference: 24) J I, Sasaki H Fau - Kakimoto T, Kakimoto T Fau - Matsuno S, Matsuno S Fau - Nakatani M, Nakatani M Fau - Kobayashi M, Kobayashi M Fau - Tatsumi K, Tatsumi K Fau - Nakano Y, Nakano Y Fau - Wakasaki H, Wakasaki H Fau - Furuta H, Furuta H Fau - Nishi M, Nishi M Fau - Nanjo K, K N: - Cardio-ankle vascular index measures arterial wall stiffness independent of blood pressure. Diabetes Res Clin Pract, 2008; 80: 265-270 – reference: 36) D'Agostino RB, Sr., Vasan RS, Pencina MJ, Wolf PA, Cobain M, Massaro JM, Kannel WB: General cardiovascular risk profile for use in primary care: the Framingham Heart Study. Circulation, 2008; 117: 743-753 – reference: 11) Horinaka S, Yabe A, Yagi H, Ishimura K, Hara H, Iemua T, Matsuoka H: Comparison of atherosclerotic indicators between cardio ankle vascular index and brachial ankle pulse wave velocity. Angiology, 2009; 60: 468-476 – reference: 14) Nambi V, Chambless L, Folsom AR, He M, Hu Y, Mosley T, Volcik K, Boerwinkle E, Ballantyne CM: Carotid intima-media thickness and presence or absence of plaque improves prediction of coronary heart disease risk: the ARIC (Atherosclerosis Risk In Communities) study. J Am Coll Cardiol, 2010; 55: 1600-1607 – reference: 30) Franssen PM, Imholz BP: Evaluation of the Mobil-O-Graph new generation ABPM device using the ESH criteria. Blood Press Monit, 2010; 15: 229-231 – reference: 2) Kanamoto M, Matsumoto N, Shiga T, Kunimoto F, Saito S: Relationship between coronary artery stenosis and cardio-ankle vascular index (CAVI) in patients undergoing cardiovascular surgery. 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Snippet | Aim: We assessed whether there is an association between the cardio-ankle vascular index (CAVI) score and the carotid intima media thickness (IMT), the pulse... [Aim] : We assessed whether there is an association between the cardio-ankle vascular index (CAVI) score and the carotid intima media thickness (IMT), the... We assessed whether there is an association between the cardio-ankle vascular index (CAVI) score and the carotid intima media thickness (IMT), the pulse wave... |
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SubjectTerms | Adult Aged Ankle - blood supply Ankle Brachial Index Anthropometry Area Under Curve Blood Pressure Body Mass Index Cardio-ankle vascular index (CAVI) Cardiovascular Diseases - diagnosis Cardiovascular Diseases - pathology Cardiovascular risk Carotid Arteries - pathology Carotid Artery Diseases - diagnosis Carotid Intima-Media Thickness Cross-Sectional Studies European Continental Ancestry Group Female Femoral Artery - pathology Genetic Predisposition to Disease Humans Linear Models Longitudinal Studies Male Middle Aged Pulse Wave Analysis Regression Analysis Risk Assessment Risk Management Sensitivity and Specificity Severity of Illness Index Vascular function Vascular structure |
Title | The Association Between the Cardio-ankle Vascular Index and Other Parameters of Vascular Structure and Function in Caucasian Adults: MARK Study |
URI | https://www.jstage.jst.go.jp/article/jat/22/9/22_28035/_article/-char/en http://mol.medicalonline.jp/en/journal/download?GoodsID=ex7domya/2015/002209/005&name=0901-0911e https://www.ncbi.nlm.nih.gov/pubmed/25994828 https://www.proquest.com/docview/1713953454 |
Volume | 22 |
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ispartofPNX | Journal of Atherosclerosis and Thrombosis, 2015/09/16, Vol.22(9), pp.901-911 |
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linkProvider | Geneva Foundation for Medical Education and Research |
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