Variant in PNPLA3 is associated with alcoholic liver disease

• Published in: Nature genetics Vol. 42; no. 1; pp. 21 - 23
• Main Authors: Tian, Chao, Stokowski, Renee P, Kershenobich, David, Ballinger, Dennis G, Hinds, David A
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.01.2010; Nature Publishing Group
• Subjects: Adult; African Americans; Agriculture; Animal Genetics and Genomics; Biological and medical sciences; Biomedical and Life Sciences; Biomedicine; brief-communication; Cancer Research; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology. Liver. Pancreas. Abdomen; Gene Frequency; Gene Function; Genetic aspects; Genetic Predisposition to Disease; Genetic Variation; Genetics of eukaryotes. Biological and molecular evolution; Genotype; Hispanic people; Human Genetics; Humans; Lipase - genetics; Liver; Liver cirrhosis; Liver Cirrhosis, Alcoholic - genetics; Liver Diseases, Alcoholic - genetics; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Logistic Models; Male; Medical sciences; Membrane Proteins - genetics; Middle Aged; Other diseases. Semiology; Polymorphism, Single Nucleotide; Principal components analysis; Regression analysis; Risk factors; Single nucleotide polymorphisms; United States; Variant; Digestive diseases; Hepatic disease; Alcoholic hepatitis

David Hinds and colleagues report that a non-synonymous variant in PNPLA3 is associated with alcoholic liver disease and liver cirrhosis. This result follows previously reported associations of this variant with nonalcoholic fatty liver disease. Two genome-wide association studies (GWAS) have descri...