Variant in PNPLA3 is associated with alcoholic liver disease
David Hinds and colleagues report that a non-synonymous variant in PNPLA3 is associated with alcoholic liver disease and liver cirrhosis. This result follows previously reported associations of this variant with nonalcoholic fatty liver disease. Two genome-wide association studies (GWAS) have descri...
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| Published in | Nature genetics Vol. 42; no. 1; pp. 21 - 23 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Nature Publishing Group US
01.01.2010
Nature Publishing Group |
| Subjects | |
| Online Access | Get full text |
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| Abstract | David Hinds and colleagues report that a non-synonymous variant in
PNPLA3
is associated with alcoholic liver disease and liver cirrhosis. This result follows previously reported associations of this variant with nonalcoholic fatty liver disease.
Two genome-wide association studies (GWAS) have described associations of variants in
PNPLA3
with nonalcoholic fatty liver and plasma liver enzyme levels. We investigated the contributions of these variants to liver disease in Mestizo subjects with a history of alcohol dependence. We found that rs738409 in
PNPLA3
is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis (unadjusted OR= 2.25,
P
=1.7 × 10
−10
; ancestry-adjusted OR=1.79,
P
=1.9 × 10
−5
). |
|---|---|
| AbstractList | Two genome-wide association studies (GWAS) have described associations of variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels. We investigated the contributions of these variants to liver disease in Mestizo subjects with a history of alcohol dependence. We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis (unadjusted OR= 2.25, P=1.7 x 10(-10); ancestry-adjusted OR=1.79, P=1.9 x 10(-5)).Two genome-wide association studies (GWAS) have described associations of variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels. We investigated the contributions of these variants to liver disease in Mestizo subjects with a history of alcohol dependence. We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis (unadjusted OR= 2.25, P=1.7 x 10(-10); ancestry-adjusted OR=1.79, P=1.9 x 10(-5)). Two genome-wide association studies (GWAS) have described associations of variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels. We investigated the contributions of these variants to liver disease in Mestizo subjects with a history of alcohol dependence. We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis (unadjusted OR = 2.25, P = 1.7 × 10^sup -10^; ancestry-adjusted OR = 1.79, P = 1.9 × 10^sup -5^). [PUBLICATION ABSTRACT] Two genome-wide association studies (GWAS) have described associations of variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels. We investigated the contributions of these variants to liver disease in Mestizo subjects with a history of alcohol dependence. We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis (unadjusted OR= 2.25, P=1.7 x 10(-10); ancestry-adjusted OR=1.79, P=1.9 x 10(-5)). David Hinds and colleagues report that a non-synonymous variant in PNPLA3 is associated with alcoholic liver disease and liver cirrhosis. This result follows previously reported associations of this variant with nonalcoholic fatty liver disease. Two genome-wide association studies (GWAS) have described associations of variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels. We investigated the contributions of these variants to liver disease in Mestizo subjects with a history of alcohol dependence. We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis (unadjusted OR= 2.25, P =1.7 × 10 −10 ; ancestry-adjusted OR=1.79, P =1.9 × 10 −5 ). Two genome-wide association studies (GWAS) have described associations of variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels. We investigated the contributions of these variants to liver disease in Mestizo subjects with a history of alcohol dependence. We found that rs738409 in PNPLA3 is strongly associated with alcoholic liver disease and clinically evident alcoholic cirrhosis (unadjusted OR= 2.25, P=1.7 10 super(-10); ancestry-adjusted OR=1.79, P=1.9 10 super(-5)). |
| Audience | Academic |
| Author | Hinds, David A Ballinger, Dennis G Kershenobich, David Tian, Chao Stokowski, Renee P |
| Author_xml | – sequence: 1 givenname: Chao surname: Tian fullname: Tian, Chao organization: Perlegen Sciences – sequence: 2 givenname: Renee P surname: Stokowski fullname: Stokowski, Renee P organization: Perlegen Sciences – sequence: 3 givenname: David surname: Kershenobich fullname: Kershenobich, David organization: Departamento de Medicina Experimental, Facultad de Medicina de la Universidad Nacional Autónoma de México – sequence: 4 givenname: Dennis G surname: Ballinger fullname: Ballinger, Dennis G organization: Perlegen Sciences, Complete Genomics, Mountain View – sequence: 5 givenname: David A surname: Hinds fullname: Hinds, David A email: david_hinds@perlegen.com organization: Perlegen Sciences |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22398029$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/19946271$$D View this record in MEDLINE/PubMed |
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| CODEN | NGENEC |
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| ContentType | Journal Article |
| Copyright | Springer Nature America, Inc. 2009 2015 INIST-CNRS COPYRIGHT 2010 Nature Publishing Group Copyright Nature Publishing Group Jan 2010 |
| Copyright_xml | – notice: Springer Nature America, Inc. 2009 – notice: 2015 INIST-CNRS – notice: COPYRIGHT 2010 Nature Publishing Group – notice: Copyright Nature Publishing Group Jan 2010 |
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| DOI | 10.1038/ng.488 |
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| References | Yoon, Y.H. & Yi, H.Y. Surveillance Report #83: Liver cirrhosis mortality in the United States, 1970–2005. (National Institute on Alcohol Abuse and Alcoholism, Arlington, Virginia, USA, 2008). RomeoSNat. Genet.20084014611465 KotronenADiabetologia20095210561060 PughRNMurray-lyonIDawsonJBr. J. Surg.197360646649 HoyumpaAHepatology200542 S1442A BaulandeSLasnierFLucasMPairaultJJ. Biol. Chem.20012763333633344 SozioMCrabbDWAm. J. Physiol. Endocrinol. Metab.2008295E10E16 YuanXAm. J. Hum. Genet.200883520528 Kollerits, B. et al. J. Med. Genet. published online doi:10.1136/jmg.2009.066597 (18 June 2009). HuangHHepatology200746297306 MannRESmartRGGovoniRAlcohol Res. Health200327209219 FloresYNAm. J. Gastroenterol.200810322312238 HindsDAAm. J. Hum. Genet.200474317325 JenkinsCMJ. Biol. Chem.20042794896848975 TianCAm. J. Hum. Genet.20078010141023 BFng488_CR7 H Huang (BFng488_CR10) 2007; 46 RE Mann (BFng488_CR3) 2003; 27 CM Jenkins (BFng488_CR12) 2004; 279 DA Hinds (BFng488_CR8) 2004; 74 RN Pugh (BFng488_CR11) 1973; 60 A Kotronen (BFng488_CR6) 2009; 52 S Baulande (BFng488_CR13) 2001; 276 X Yuan (BFng488_CR5) 2008; 83 C Tian (BFng488_CR9) 2007; 80 S Romeo (BFng488_CR4) 2008; 40 M Sozio (BFng488_CR14) 2008; 295 BFng488_CR1 A Hoyumpa (BFng488_CR15) 2005; 42 S1 YN Flores (BFng488_CR2) 2008; 103 18940312 - Am J Hum Genet. 2008 Oct;83(4):520-8 15364929 - J Biol Chem. 2004 Nov 19;279(47):48968-75 18671818 - Am J Gastroenterol. 2008 Sep;103(9):2231-8 15535449 - Alcohol Res Health. 2003;27(3):209-19 20373372 - Hepatology. 2010 Apr;51(4):1463-5 17461418 - Hepatology. 2007 Aug;46(2):297-306 17557415 - Am J Hum Genet. 2007 Jun;80(6):1014-23 18349117 - Am J Physiol Endocrinol Metab. 2008 Jul;295(1):E10-6 14740319 - Am J Hum Genet. 2004 Feb;74(2):317-25 11431482 - J Biol Chem. 2001 Sep 7;276(36):33336-44 4541913 - Br J Surg. 1973 Aug;60(8):646-9 18820647 - Nat Genet. 2008 Dec;40(12):1461-5 19224197 - Diabetologia. 2009 Jun;52(6):1056-60 |
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| Snippet | David Hinds and colleagues report that a non-synonymous variant in
PNPLA3
is associated with alcoholic liver disease and liver cirrhosis. This result follows... Two genome-wide association studies (GWAS) have described associations of variants in PNPLA3 with nonalcoholic fatty liver and plasma liver enzyme levels. We... |
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| SubjectTerms | Adult African Americans Agriculture Animal Genetics and Genomics Biological and medical sciences Biomedical and Life Sciences Biomedicine brief-communication Cancer Research Female Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Gene Frequency Gene Function Genetic aspects Genetic Predisposition to Disease Genetic Variation Genetics of eukaryotes. Biological and molecular evolution Genotype Hispanic people Human Genetics Humans Lipase - genetics Liver Liver cirrhosis Liver Cirrhosis, Alcoholic - genetics Liver Diseases, Alcoholic - genetics Liver. Biliary tract. Portal circulation. Exocrine pancreas Logistic Models Male Medical sciences Membrane Proteins - genetics Middle Aged Other diseases. Semiology Polymorphism, Single Nucleotide Principal components analysis Regression analysis Risk factors Single nucleotide polymorphisms |
| Title | Variant in PNPLA3 is associated with alcoholic liver disease |
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