Prooxidant Effects of Epigallocatechin-3-Gallate in Health Benefits and Potential Adverse Effect

• Published in: Oxidative medicine and cellular longevity Vol. 2020; no. 2020; pp. 1 - 14
• Main Authors: Huang, Jianan, Liu, Zhonghua, Zhu, Kun, Ouyang, Jie
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc
• Subjects: Analysis; Animals; Antioxidants; Apoptosis; Cancer; Care and treatment; Catechin; Catechin - adverse effects; Catechin - analogs & derivatives; Catechin - chemistry; Cell growth; Complications and side effects; Green tea; Health; Health insurance; Humans; Kinases; Lipid Metabolism - drug effects; Models, Biological; Oxidation-Reduction; Reactive oxygen species; Reactive Oxygen Species - toxicity; Review; Tea

Epigallocatechin-3-gallate (EGCG) is the major polyphenolic compound present in green tea and is generally regarded as an effective antioxidant. However, its chemical reactivity makes it susceptible to generate reactive oxygen species (ROS) via autooxidation and exhibit prooxidant effects. The proox...