Prooxidant Effects of Epigallocatechin-3-Gallate in Health Benefits and Potential Adverse Effect
Epigallocatechin-3-gallate (EGCG) is the major polyphenolic compound present in green tea and is generally regarded as an effective antioxidant. However, its chemical reactivity makes it susceptible to generate reactive oxygen species (ROS) via autooxidation and exhibit prooxidant effects. The proox...
Saved in:
| Published in | Oxidative medicine and cellular longevity Vol. 2020; no. 2020; pp. 1 - 14 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Cairo, Egypt
Hindawi Publishing Corporation
2020
Hindawi John Wiley & Sons, Inc |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Epigallocatechin-3-gallate (EGCG) is the major polyphenolic compound present in green tea and is generally regarded as an effective antioxidant. However, its chemical reactivity makes it susceptible to generate reactive oxygen species (ROS) via autooxidation and exhibit prooxidant effects. The prooxidant actions of EGCG could play a dual role, being both beneficial and harmful. This review summarized recent research progress on (1) the anticancer, antiobesity, and antibacterial effects of EGCG and (2) the possible toxicity of EGCG. The major focus is on the involvement of prooxidant effects of EGCG and their effective doses used. Considering dosage is a crucial factor in the prooxidant effects of EGCG; further studies are required to find the appropriate dose at which EGCG could bring more health benefits with lower toxicity. |
|---|---|
| AbstractList | Epigallocatechin-3-gallate (EGCG) is the major polyphenolic compound present in green tea and is generally regarded as an effective antioxidant. However, its chemical reactivity makes it susceptible to generate reactive oxygen species (ROS) via autooxidation and exhibit prooxidant effects. The prooxidant actions of EGCG could play a dual role, being both beneficial and harmful. This review summarized recent research progress on (1) the anticancer, antiobesity, and antibacterial effects of EGCG and (2) the possible toxicity of EGCG. The major focus is on the involvement of prooxidant effects of EGCG and their effective doses used. Considering dosage is a crucial factor in the prooxidant effects of EGCG; further studies are required to find the appropriate dose at which EGCG could bring more health benefits with lower toxicity. Epigallocatechin-3-gallate (EGCG) is the major polyphenolic compound present in green tea and is generally regarded as an effective antioxidant. However, its chemical reactivity makes it susceptible to generate reactive oxygen species (ROS) via autooxidation and exhibit prooxidant effects. The prooxidant actions of EGCG could play a dual role, being both beneficial and harmful. This review summarized recent research progress on (1) the anticancer, antiobesity, and antibacterial effects of EGCG and (2) the possible toxicity of EGCG. The major focus is on the involvement of prooxidant effects of EGCG and their effective doses used. Considering dosage is a crucial factor in the prooxidant effects of EGCG; further studies are required to find the appropriate dose at which EGCG could bring more health benefits with lower toxicity.Epigallocatechin-3-gallate (EGCG) is the major polyphenolic compound present in green tea and is generally regarded as an effective antioxidant. However, its chemical reactivity makes it susceptible to generate reactive oxygen species (ROS) via autooxidation and exhibit prooxidant effects. The prooxidant actions of EGCG could play a dual role, being both beneficial and harmful. This review summarized recent research progress on (1) the anticancer, antiobesity, and antibacterial effects of EGCG and (2) the possible toxicity of EGCG. The major focus is on the involvement of prooxidant effects of EGCG and their effective doses used. Considering dosage is a crucial factor in the prooxidant effects of EGCG; further studies are required to find the appropriate dose at which EGCG could bring more health benefits with lower toxicity. |
| Audience | Academic |
| Author | Ouyang, Jie Huang, Jianan Zhu, Kun Liu, Zhonghua |
| AuthorAffiliation | 2 Collaborative Innovation Centre of Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha, China 1 National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha, China 3 Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha, China |
| AuthorAffiliation_xml | – name: 2 Collaborative Innovation Centre of Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha, China – name: 1 National Research Center of Engineering Technology for Utilization of Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha, China – name: 3 Key Laboratory of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha, China |
| Author_xml | – sequence: 1 fullname: Huang, Jianan – sequence: 2 fullname: Liu, Zhonghua – sequence: 3 fullname: Zhu, Kun – sequence: 4 fullname: Ouyang, Jie |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32850004$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkk1v1DAQhi3Uin5x44wicUFqQ_0VJ75UWqqlRarUHuBsvPa46yprL7G30H-Po01bqIQ42SM_8868njlAOyEGQOgtwR8JaZpTiik-lS1lohOv0D6RnNZYSr7zdMd4Dx2kdIexYJST12iP0a7BGPN99P1miPGXtzrkau4cmJyq6Kr52t_qvo9GZzBLH2pWX5S4RJUP1SXoPi-rTxDA-ZKgg61uYoaQve6rmb2HIcEkd4R2ne4TvJnOQ_Tt8_zr-WV9dX3x5Xx2VZtGNLnmLbEGOi00c1QDsdYsWgeia7QlrCMgFhy4pTBipnOyBantwkpitHRSskN0ttVdbxYrKFDIg-7VevArPTyoqL36-yX4pbqN96rlnHDaFIEPk8AQf2wgZbXyyUAxHSBukqKctR1vOB9rvX-B3sXNEIq9kRKMt53gz1T5SVA-uFjqmlFUzQTHHSOS0UK9-7Pvp4YfR1QAugXMEFMawCnjs84-jjZ8rwhW4x6ocQ_UtAcl6eRF0qPuP_DjLV5GbfVP_z96ahkKA04_0xQLUlz9BkN5yd8 |
| CitedBy_id | crossref_primary_10_3390_cancers15030862 crossref_primary_10_37527_2022_72_3_006 crossref_primary_10_1080_10408398_2022_2068500 crossref_primary_10_1016_j_smaim_2022_12_003 crossref_primary_10_3389_fphar_2023_1096614 crossref_primary_10_1016_j_nut_2024_112517 crossref_primary_10_3390_molecules26051200 crossref_primary_10_1016_j_jhazmat_2024_135873 crossref_primary_10_1080_10937404_2023_2224119 crossref_primary_10_3390_antiox12020407 crossref_primary_10_3390_cancers15143585 crossref_primary_10_1080_17435889_2025_2462521 crossref_primary_10_2174_0115734013276165231129102513 crossref_primary_10_3390_cancers16122171 crossref_primary_10_3390_ph14100946 crossref_primary_10_1016_j_bbamem_2023_184264 crossref_primary_10_4103_1735_5362_314822 crossref_primary_10_3390_biom14121497 crossref_primary_10_1021_acs_langmuir_0c03449 crossref_primary_10_1016_j_bone_2020_115680 crossref_primary_10_3390_ph17080975 crossref_primary_10_3390_nu16172996 crossref_primary_10_3389_fnut_2022_987911 crossref_primary_10_3389_fphar_2023_1192714 crossref_primary_10_1016_j_hermed_2023_100694 crossref_primary_10_1080_07391102_2023_2212066 crossref_primary_10_1016_j_micpath_2024_107172 crossref_primary_10_3390_nu15061439 crossref_primary_10_1021_acsami_2c20334 crossref_primary_10_1111_jfbc_14189 crossref_primary_10_1016_j_intimp_2021_107464 crossref_primary_10_1016_j_cofs_2022_100921 crossref_primary_10_3390_ijms252111656 crossref_primary_10_3389_fphar_2021_753548 crossref_primary_10_3389_fphar_2023_1201085 crossref_primary_10_1016_j_porgcoat_2022_106796 crossref_primary_10_3390_ijms242115972 crossref_primary_10_3390_molecules27123816 crossref_primary_10_1155_2021_5546493 crossref_primary_10_1080_10408398_2023_2180478 crossref_primary_10_3390_antibiotics13121211 crossref_primary_10_3390_ijms23116075 crossref_primary_10_1093_bfgp_elac055 crossref_primary_10_1016_j_foodchem_2024_139186 crossref_primary_10_1002_EXP_20230066 crossref_primary_10_1002_btm2_10373 crossref_primary_10_1080_15287394_2020_1867275 crossref_primary_10_3389_fbioe_2021_759303 crossref_primary_10_3390_ijms24065602 crossref_primary_10_3390_nu16234100 crossref_primary_10_1080_10408398_2022_2038540 crossref_primary_10_3390_molecules27144560 crossref_primary_10_1089_ars_2023_0442 crossref_primary_10_26599_FSHW_2022_9250129 crossref_primary_10_1155_2022_3311228 crossref_primary_10_1080_00914037_2024_2398550 crossref_primary_10_1002_jbt_22999 crossref_primary_10_1016_j_bbrep_2023_101536 crossref_primary_10_1038_s41598_024_72269_3 crossref_primary_10_46413_boneyusbad_1415742 crossref_primary_10_1080_13813455_2024_2401892 crossref_primary_10_3389_fphar_2022_806470 crossref_primary_10_1016_j_foodchem_2023_136034 crossref_primary_10_1039_D1FO02974F crossref_primary_10_1039_D4AY01733A crossref_primary_10_1007_s43440_024_00585_6 crossref_primary_10_3390_ijms21217940 crossref_primary_10_1016_j_colsurfb_2024_113971 crossref_primary_10_1016_j_foodres_2024_114548 crossref_primary_10_1155_2022_7848811 crossref_primary_10_3389_fnut_2024_1425839 crossref_primary_10_1021_acs_langmuir_1c01742 crossref_primary_10_1016_j_microc_2023_108917 crossref_primary_10_3390_ph15121540 crossref_primary_10_58920_sciphy02020001 |
| Cites_doi | 10.1016/j.yrtph.2017.01.002 10.1021/tx050151l 10.1016/j.canlet.2005.10.021 10.3892/ijo.2013.1920 10.1016/j.taap.2010.10.005 10.1016/j.jff.2014.01.008 10.1080/10408398.2016.1231168 10.1016/S1383-5718(02)00245-0 10.1002/ptr.6063 10.1016/S0006-2952(03)00541-0 10.3390/molecules21101305 10.1002/mnfr.201400485 10.1016/j.jnutbio.2015.07.001 10.1093/toxsci/kfh001 10.7314/APJCP.2012.13.9.4815 10.1002/lt.21021 10.2741/2446 10.1093/carcin/bgi040 10.1158/0008-5472.CAN-05-0480 10.1016/j.fct.2005.11.003 10.1016/j.ejbas.2017.12.001 10.1016/j.bbrc.2012.03.120 10.1002/mnfr.200800013 10.1016/j.foodchem.2016.08.098 10.1111/jpi.12281 10.1016/j.toxrep.2016.03.001 10.1017/S0007114510004824 10.1016/j.mce.2017.07.024 10.1016/j.foodchem.2012.02.132 10.1074/jbc.RA118.002579 10.1158/1078-0432.CCR-04-2273 10.1038/nrmicro3032 10.1016/j.pathophys.2009.07.004 10.1093/carcin/bgq039 10.1271/bbb.63.430 10.3390/ijms19010016 10.1016/j.ejphar.2006.04.040 10.1038/srep40617 10.1038/ijo.2011.136 10.1016/j.fitote.2013.07.014 10.3389/fmicb.2018.00246 10.1271/bbb.67.2632 10.1016/j.fm.2011.08.019 10.1016/j.foodchem.2013.05.122 10.1093/carcin/bgg091 10.1080/07315724.2006.10719518 10.1016/j.jnutbio.2012.06.013 10.1155/2015/476180 10.2903/j.efsa.2018.5239 10.1093/carcin/bgh168 10.1152/ajpcell.00569.2004 10.1021/acs.jafc.7b05830 10.1152/ajpendo.00325.2005 10.1248/bpb.27.277 10.1016/j.fct.2009.10.030 10.1016/j.dsx.2019.03.021 10.1016/j.nutres.2009.10.003 10.1002/mnfr.201300417 10.1016/j.taap.2014.12.018 10.1016/j.fct.2005.07.005 10.1016/j.freeradbiomed.2010.09.031 10.1016/j.jep.2017.08.035 10.1007/BF02976881 10.1016/j.yrtph.2018.03.019 10.1007/s12192-011-0280-8 10.1093/carcin/19.4.611 10.3390/toxins8020037 10.3177/jnsv.43.679 10.3389/fmicb.2014.00434 10.1152/ajpgi.2001.281.5.G1135 10.1016/j.lfs.2005.11.004 10.2220/biomedres.33.9 10.1111/lam.13058 10.1016/j.clnu.2013.03.008 10.1111/j.1464-410X.2004.04785.x 10.1016/j.foodcont.2020.107148 10.2174/187152107779314124 10.1016/j.freeradbiomed.2008.07.023 10.3746/pnf.2016.21.1.62 10.1016/j.freeradbiomed.2005.09.014 10.1196/annals.1397.046 10.1002/jcp.20569 10.1074/jbc.M604748200 |
| ContentType | Journal Article |
| Copyright | Copyright © 2020 Jie Ouyang et al. COPYRIGHT 2020 John Wiley & Sons, Inc. Copyright © 2020 Jie Ouyang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0 Copyright © 2020 Jie Ouyang et al. 2020 |
| Copyright_xml | – notice: Copyright © 2020 Jie Ouyang et al. – notice: COPYRIGHT 2020 John Wiley & Sons, Inc. – notice: Copyright © 2020 Jie Ouyang et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. http://creativecommons.org/licenses/by/4.0 – notice: Copyright © 2020 Jie Ouyang et al. 2020 |
| DBID | ADJCN AHFXO RHU RHW RHX AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7X7 7XB 88E 8FI 8FJ 8FK 8G5 ABUWG AFKRA AZQEC BENPR CCPQU DWQXO FYUFA GHDGH GNUQQ GUQSH K9. M0S M1P M2O MBDVC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS Q9U 7X8 5PM |
| DOI | 10.1155/2020/9723686 |
| DatabaseName | الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete Hindawi Publishing Complete Hindawi Publishing Subscription Journals Hindawi Publishing Open Access CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Hospital Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Research Library ProQuest Central (Alumni) ProQuest Central UK/Ireland ProQuest Central Essentials ProQuest Central ProQuest One Community College ProQuest Central Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student Research Library Prep ProQuest Health & Medical Complete (Alumni) Health & Medical Collection (Alumni) Medical Database Research Library Research Library (Corporate) ProQuest Central Premium ProQuest One Academic Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China ProQuest Central Basic MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Publicly Available Content Database Research Library Prep ProQuest Central Student ProQuest One Academic Middle East (New) ProQuest Central Essentials ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing Research Library (Alumni Edition) ProQuest Central China ProQuest Central ProQuest Health & Medical Research Collection Health Research Premium Collection Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Health & Medical Research Collection ProQuest Research Library ProQuest Central (New) ProQuest Medical Library (Alumni) ProQuest Central Basic ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Publicly Available Content Database MEDLINE MEDLINE - Academic CrossRef |
| Database_xml | – sequence: 1 dbid: RHX name: Hindawi Publishing Open Access url: http://www.hindawi.com/journals/ sourceTypes: Publisher – sequence: 2 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 4 dbid: BENPR name: ProQuest Central (ProQuest) url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Biology |
| EISSN | 1942-0994 |
| Editor | Malaguti, Marco |
| Editor_xml | – sequence: 1 givenname: Marco surname: Malaguti fullname: Malaguti, Marco |
| EndPage | 14 |
| ExternalDocumentID | PMC7441425 A640831932 32850004 10_1155_2020_9723686 1206119 |
| Genre | Journal Article Review |
| GrantInformation_xml | – fundername: National Natural Science Foundation of China grantid: 31471706; 31801547; 31871764 |
| GroupedDBID | --- 24P 3V. 4.4 53G 5VS 7X7 88E 8FI 8FJ 8G5 AAFWJ AAJEY ABUWG ADBBV ADJCN ADRAZ AENEX AFKRA AHFXO AHMBA ALIPV ALMA_UNASSIGNED_HOLDINGS AOIJS AZQEC BAWUL BCNDV BENPR BPHCQ BVXVI CCPQU DIK DWQXO E3Z EBD EBS EJD EMOBN F5P FYUFA GNUQQ GROUPED_DOAJ GUQSH H13 HMCUK HYE IAO IEA IHR INH INR IPNFZ KQ8 M1P M2O M48 M~E O5R O5S OK1 PGMZT PIMPY PQQKQ PROAC PSQYO RHX RIG RNS RPM SV3 TR2 UKHRP ITC RHU RHW 0R~ AAYXX ACCMX CITATION PHGZM PHGZT AAMMB AEFGJ AGXDD AIDQK AIDYY CGR CUY CVF ECM EIF NPM PJZUB PPXIY 7XB 8FK K9. MBDVC PKEHL PQEST PQUKI PRINS Q9U 7X8 5PM |
| ID | FETCH-LOGICAL-c565t-471dce8a6a3f2ae1ddcb7fe685ad1381e6b4e4d2e1dcec8f97e9adbd91ca9f993 |
| IEDL.DBID | M48 |
| ISSN | 1942-0900 1942-0994 |
| IngestDate | Thu Aug 21 14:10:56 EDT 2025 Fri Jul 11 02:29:19 EDT 2025 Fri Jul 25 20:53:07 EDT 2025 Tue Jun 17 22:02:53 EDT 2025 Mon Jul 21 05:56:32 EDT 2025 Tue Jul 01 02:52:33 EDT 2025 Thu Apr 24 22:53:42 EDT 2025 Sun Jun 02 18:50:29 EDT 2024 Tue Nov 26 16:45:40 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2020 |
| Language | English |
| License | This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 Copyright © 2020 Jie Ouyang et al. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c565t-471dce8a6a3f2ae1ddcb7fe685ad1381e6b4e4d2e1dcec8f97e9adbd91ca9f993 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 Academic Editor: Marco Malaguti |
| ORCID | 0000-0002-7573-2623 0000-0002-9773-7599 0000-0003-0000-4565 0000-0003-1531-016X |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.1155/2020/9723686 |
| PMID | 32850004 |
| PQID | 2436347864 |
| PQPubID | 2037493 |
| PageCount | 14 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_7441425 proquest_miscellaneous_2437845449 proquest_journals_2436347864 gale_infotracmisc_A640831932 pubmed_primary_32850004 crossref_citationtrail_10_1155_2020_9723686 crossref_primary_10_1155_2020_9723686 hindawi_primary_10_1155_2020_9723686 emarefa_primary_1206119 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2020-00-00 |
| PublicationDateYYYYMMDD | 2020-01-01 |
| PublicationDate_xml | – year: 2020 text: 2020-00-00 |
| PublicationDecade | 2020 |
| PublicationPlace | Cairo, Egypt |
| PublicationPlace_xml | – name: Cairo, Egypt – name: United States – name: New York |
| PublicationTitle | Oxidative medicine and cellular longevity |
| PublicationTitleAlternate | Oxid Med Cell Longev |
| PublicationYear | 2020 |
| Publisher | Hindawi Publishing Corporation Hindawi John Wiley & Sons, Inc |
| Publisher_xml | – name: Hindawi Publishing Corporation – name: Hindawi – name: John Wiley & Sons, Inc |
| References | (39) 2020 44 88 45 89 46 47 48 49 50 51 52 53 10 54 11 55 12 56 13 57 14 58 15 59 16 17 (43) 2002; 62 18 1 2 3 4 5 6 7 8 9 60 61 62 63 20 64 21 65 22 66 23 67 24 68 25 69 26 27 28 (32) 2010; 30 29 70 71 72 73 30 74 31 75 76 33 77 34 78 35 79 36 37 (19) 2007; 31 (85) 2013; 37 (38) 2009; 29 80 81 82 83 40 84 41 42 86 87 |
| References_xml | – ident: 88 doi: 10.1016/j.yrtph.2017.01.002 – ident: 74 doi: 10.1021/tx050151l – ident: 16 doi: 10.1016/j.canlet.2005.10.021 – ident: 36 doi: 10.3892/ijo.2013.1920 – ident: 46 doi: 10.1016/j.taap.2010.10.005 – ident: 50 doi: 10.1016/j.jff.2014.01.008 – ident: 11 doi: 10.1080/10408398.2016.1231168 – ident: 86 doi: 10.1016/S1383-5718(02)00245-0 – ident: 6 doi: 10.1002/ptr.6063 – ident: 40 doi: 10.1016/S0006-2952(03)00541-0 – ident: 2 doi: 10.3390/molecules21101305 – ident: 31 doi: 10.1002/mnfr.201400485 – ident: 83 doi: 10.1016/j.jnutbio.2015.07.001 – volume: 30 start-page: 2519 issue: 7 year: 2010 ident: 32 publication-title: Anticancer Research – ident: 75 doi: 10.1093/toxsci/kfh001 – ident: 21 doi: 10.7314/APJCP.2012.13.9.4815 – ident: 7 doi: 10.1002/lt.21021 – ident: 33 doi: 10.2741/2446 – ident: 34 doi: 10.1093/carcin/bgi040 – ident: 26 doi: 10.1158/0008-5472.CAN-05-0480 – ident: 73 doi: 10.1016/j.fct.2005.11.003 – ident: 37 doi: 10.1016/j.ejbas.2017.12.001 – ident: 23 doi: 10.1016/j.bbrc.2012.03.120 – ident: 48 doi: 10.1002/mnfr.200800013 – ident: 57 doi: 10.1016/j.foodchem.2016.08.098 – start-page: 1 year: 2020 ident: 39 publication-title: Journal of Cellular Physiology – ident: 70 doi: 10.1111/jpi.12281 – ident: 67 doi: 10.1016/j.toxrep.2016.03.001 – ident: 84 doi: 10.1017/S0007114510004824 – ident: 44 doi: 10.1016/j.mce.2017.07.024 – ident: 5 doi: 10.1016/j.foodchem.2012.02.132 – ident: 49 doi: 10.1074/jbc.RA118.002579 – ident: 30 doi: 10.1158/1078-0432.CCR-04-2273 – ident: 61 doi: 10.1038/nrmicro3032 – ident: 80 doi: 10.1016/j.pathophys.2009.07.004 – ident: 28 doi: 10.1093/carcin/bgq039 – ident: 76 doi: 10.1271/bbb.63.430 – ident: 35 doi: 10.3390/ijms19010016 – ident: 17 doi: 10.1016/j.ejphar.2006.04.040 – ident: 81 doi: 10.1038/srep40617 – ident: 52 doi: 10.1038/ijo.2011.136 – ident: 72 doi: 10.1016/j.fitote.2013.07.014 – ident: 62 doi: 10.3389/fmicb.2018.00246 – ident: 12 doi: 10.1271/bbb.67.2632 – ident: 58 doi: 10.1016/j.fm.2011.08.019 – ident: 1 doi: 10.1016/j.foodchem.2013.05.122 – ident: 24 doi: 10.1093/carcin/bgg091 – ident: 9 doi: 10.1080/07315724.2006.10719518 – ident: 25 doi: 10.1016/j.jnutbio.2012.06.013 – volume: 62 start-page: 7241 issue: 24 year: 2002 ident: 43 publication-title: Cancer Research – ident: 69 doi: 10.1155/2015/476180 – ident: 64 doi: 10.2903/j.efsa.2018.5239 – ident: 29 doi: 10.1093/carcin/bgh168 – ident: 47 doi: 10.1152/ajpcell.00569.2004 – ident: 3 doi: 10.1021/acs.jafc.7b05830 – ident: 87 doi: 10.1152/ajpendo.00325.2005 – ident: 14 doi: 10.1248/bpb.27.277 – ident: 65 doi: 10.1016/j.fct.2009.10.030 – ident: 10 doi: 10.1016/j.dsx.2019.03.021 – ident: 51 doi: 10.1016/j.nutres.2009.10.003 – ident: 41 doi: 10.1002/mnfr.201300417 – ident: 71 doi: 10.1016/j.taap.2014.12.018 – volume: 31 start-page: 705 issue: 4 year: 2007 ident: 19 publication-title: International Journal of Oncology – ident: 56 doi: 10.1016/j.fct.2005.07.005 – ident: 22 doi: 10.1016/j.freeradbiomed.2010.09.031 – ident: 8 doi: 10.1016/j.jep.2017.08.035 – ident: 82 doi: 10.1007/BF02976881 – ident: 78 doi: 10.1016/j.yrtph.2018.03.019 – ident: 79 doi: 10.1007/s12192-011-0280-8 – ident: 27 doi: 10.1093/carcin/19.4.611 – ident: 42 doi: 10.3390/toxins8020037 – ident: 66 doi: 10.3177/jnsv.43.679 – ident: 55 doi: 10.3389/fmicb.2014.00434 – ident: 89 doi: 10.1152/ajpgi.2001.281.5.G1135 – ident: 4 doi: 10.1016/j.lfs.2005.11.004 – ident: 54 doi: 10.2220/biomedres.33.9 – ident: 63 doi: 10.1111/lam.13058 – ident: 15 doi: 10.1016/j.clnu.2013.03.008 – volume: 29 start-page: 1435 issue: 4 year: 2009 ident: 38 publication-title: Anticancer Research – ident: 18 doi: 10.1111/j.1464-410X.2004.04785.x – ident: 60 doi: 10.1016/j.foodcont.2020.107148 – ident: 59 doi: 10.2174/187152107779314124 – ident: 13 doi: 10.1016/j.freeradbiomed.2008.07.023 – ident: 53 doi: 10.3746/pnf.2016.21.1.62 – volume: 37 start-page: 247 issue: 3 year: 2013 ident: 85 publication-title: Drug and Chemical Toxicology – ident: 68 doi: 10.1016/j.freeradbiomed.2005.09.014 – ident: 20 doi: 10.1196/annals.1397.046 – ident: 45 doi: 10.1002/jcp.20569 – ident: 77 doi: 10.1074/jbc.M604748200 |
| SSID | ssj0063241 |
| Score | 2.521541 |
| SecondaryResourceType | review_article |
| Snippet | Epigallocatechin-3-gallate (EGCG) is the major polyphenolic compound present in green tea and is generally regarded as an effective antioxidant. However, its... |
| SourceID | pubmedcentral proquest gale pubmed crossref hindawi emarefa |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 1 |
| SubjectTerms | Analysis Animals Antioxidants Apoptosis Cancer Care and treatment Catechin Catechin - adverse effects Catechin - analogs & derivatives Catechin - chemistry Cell growth Complications and side effects Green tea Health Health insurance Humans Kinases Lipid Metabolism - drug effects Models, Biological Oxidation-Reduction Reactive oxygen species Reactive Oxygen Species - toxicity Review Tea |
| SummonAdditionalLinks | – databaseName: Hindawi Publishing Open Access dbid: RHX link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwjV1Lb9QwELZopZW4IJ4lsCAjlROy2CSOH8eCWlZIoB6otLfgx0SNBNmKTdXy75lJvIEtILgl8vghj8fzjT2eYeywitZpAwuBBq0SElWGsNZ7ERGtyzLoJlh6nPzho1qeyferapWCJG1-v8JHbUfm-eI1JcdSRu2xPVxgZJQvV9sNlwKOD3aVlQUdOyy2_u036u5onhl8dfjhpp14dk428FX7J6R502HyFw10cpfdSdCRH428vsduQXefzcZkkt8fsM-nCIKv24hTxceYxBu-bvjxRTtcrpPnE_lNilK8o8PzHnjb8fEVEn-DO17TYgXXRX667smFiLqibM0bSM09ZGcnx5_eLkXKnyACwrReoN7BERunXNkUDvIYg9cNKFO5mKOmBuUlyFgAkQXTWA3WRR9tHpxtELg8YvvduoPHjOdSQ2OUR3znZWUrR8mpXR4RrzgPGjL2aju3dUjBxSnHxZd6MDKqqiZO1IkTGXs5UV-MQTX-QneQ2PSTrEAAktuMzYltNUkh9hNQJkJ9pCTlTUNEmrHDxM5_tD_f8rpOorupC1mqUmqjZMZeTMXUAbmjdbC-HGi0kZWUOJCDcWlMHZWFoSQTWFvvLJqJgAJ675Z07fkQ2FsjNsU99Mn_jf4pu02_43nQnO333y7hGSKk3j8f5OMHxm0G1A priority: 102 providerName: Hindawi Publishing – databaseName: Health & Medical Collection dbid: 7X7 link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV3da9RAEF9qy4EvolVr9Cor1CdZekn2I_tU2tIPCkofLNxb3K_QQE1OL0X733cm2UtbUft2kEl2LzM7-5vJ7PwI2RFeG1WEGYOAVjIOWwbT2lrmAa3z3KnKaTyc_PmLPL3gZ3Mxjwm3ZSyrXPnE3lH71mGOfDfjucy5KiTfW_xgyBqFX1cjhcYTsoGty9Cq1XwMuLATeR9waZ5hPmK2KnwXAmP-2S4ybkk8RX1vS5qE7wZ-mNFFTy4xOP5V_w2C_llJeW9rOn5OnkVMSfcHI3hB1kKzSSYDy-TNS_LtHNDx79rDO6RDs-IlbSt6tKj7r-5YEoUFlSxnJ5hV7wKtGzocT6IH4AqrGm4wjafnbYe1RTgU0jgvQ3zcK3JxfPT18JRFYgXmAL91DDYkmHFhpMmrzITUe2dVFWQhjE9hCw_S8sB9FlDMFZVWQRtvvU6d0RUgmtdkvWmb8IbQlKtQFdIC8LNcaGGQtdqkHoCMsUGFhHxavdvSxa7jSH5xVfbRhxAlaqKMmkjIx1F6MXTb-IfcVlTTnVgGyCTVCZmi2kpcnjCOg8Xiyn3JkVANoGpCdqI6H3n-dKXrMq7pZXlngQn5MF7GAbBOrQntdS-jCi44h4lsDaYxDpRnBbJPwN3qgdGMAtjp--GVpr7sO34rAK3gXN_-f1rvyFP8E0OCaErWu5_XYRsgU2ff9-viFjVfERc priority: 102 providerName: ProQuest |
| Title | Prooxidant Effects of Epigallocatechin-3-Gallate in Health Benefits and Potential Adverse Effect |
| URI | https://search.emarefa.net/detail/BIM-1206119 https://dx.doi.org/10.1155/2020/9723686 https://www.ncbi.nlm.nih.gov/pubmed/32850004 https://www.proquest.com/docview/2436347864 https://www.proquest.com/docview/2437845449 https://pubmed.ncbi.nlm.nih.gov/PMC7441425 |
| Volume | 2020 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwhV1La9tAEB7ywNBLSV-JWteokJ6KWkva5yGEpDg1hQQTavBNXWlXRJDKaazQ5N9nRq_WIW0vQqBZrbQzu_PNajQfwD632kjlxgEGtCJg6DICrdM0sIjWWZzJPNP0c_LpmZjO2dcFX2xAxzbaDuDq0dCO-KTm15cfb3_eHeKEP6gnPOcUv48_EXuWUGITttEnSeIyOGX99wSqSV6HXppFtDMx7lLgH7Rec04D98PgiekX68EFhcm_isfA6MOcyj-c1MkOPG3RpX_UmMMz2HDlcxg0fJN3L-D7DHHybWFxNP2mbPHKX-b-5Kqov79TchSlVgZx8IX21yvnF6Xf_KjkH-OimBfYwJTWny0ryjKirojQeeXa272E-cnk2-dp0FIsBBkiuSpA14RPrIwwcR4ZF1qbpTJ3QnFjQ3TmTqTMMRs5EstUrqXTxqZWh5nROWKbV7BVLku3B37IpMuVSBECpoxrboi_2oQWIY1JnXQefOjGNsna-uNEg3GZ1HEI5wlpImk14cH7XvqqqbvxF7ndVk2_xSLEKKH2YEhqS8h0sJ8Mp02WHAlG1GoIWj3Yb9X5n_sPO10nnXEmEYtFzKQSzIN3_WXqgDLWSre8qWWkYpwxfJDdxjT6juJIEQ8FtpZrRtMLUM3v9StlcVHX_pYIX3GZff3vl3sDT-glmq2iIWxV1zfuLYKnKh3BplzIEWwfT85m56N6luDxfLq4B-0bFhg |
| linkProvider | Scholars Portal |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELaqohVcEM82sBQjtSdkdZP4ER8QKrRlSx_qoZX2ljq2o0aCZGFTlf4pfiMzebVFPE69RcokTjL2zDeT8XyErAunjUr8hEFAKxkHl8G0zjLmAK3z2KrcatycfHgkp6f880zMlsjPfi8MllX2NrEx1K6ymCPfjHgsY64Syd_PvzFkjcK_qz2FRjst9v3VJYRsi3d726DfjSja3Tn5OGUdqwCzAF5qBtbYWZ8YaeI8Mj50zmYq9zIRxoXgv7zMuOcu8ihmk1wrr43LnA6t0bnG5ktg8u-B451gsKdmQ4CHnc-bAE_zCPMfk77QXgjMMUw2keFL4q7tGy5w5L8aODCDSxidYzB-WfwJ8v5euXnDFe4-Ig87DEu32kn3mCz58gkZtayWV0_J2TGg8R-FA53RtjnyglY53ZkXzV9-LMHCAk4Ws0-Yxa89LUraboeiH8D05gVcYEpHj6saa5lwKKSNXvjuds_I6Z188udkuaxKv0poyJXPE5kB0My40MIgS7YJHQAnk3nlA_K2_7ap7bqcI9nGl7SJdoRIURNpp4mAbAzS87a7x1_kVjo1XYtFgIRCHZAxqi1FcwDjWFicNt2SHAncABoHZL1T53_uP-51nXY2ZJFez_iAvBlO4wBYF1f66qKRUQkXnMODrLRTYxgojhJku4Cr1a1JMwhgZ_HbZ8rivOkwrgAkgzF_8e_Hek3uT08OD9KDvaP9l-QBvlCbnBqT5fr7hX8FcK3O1po1QsnZXS_KX3giUaY |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1Lb9QwELaqrRZxQTxLygJGak_I2k3i2PEBoZbu0lJYrRCVeksd21EjQbJlU5X-NX4dM3m1RTxOvUXKJE4y9sw3k_F8hGxFVmkZuwmDgFYwDi6DKZWmzAJa56GRmVG4OfnTXOwf8Q_H0fEa-dnthcGyys4m1obalgZz5OOAhyLkMhZ8nLVlEYu92dvlGUMGKfzT2tFpNFPk0F1eQPi2enOwB7reDoLZ9Mu7fdYyDDADQKZiYJmtcbEWOswC7XxrTSozJ-JIWx98mRMpd9wGDsVMnCnplLapVb7RKlPYiAnM_7rEqGhA1nen88Xnzg9gH_Q63FM8wGzIpCu7jyLMOEzGyPclcA_3NYc4dN80HOjeQQxPMTS_yP8EgH-v47zmGGf3yb0W0dKdZgo-IGuueEiGDcfl5SNysgBs_iO3oEHatEpe0TKj02Ve__PHgiws52Qhe485_crRvKDN5ii6C4Y4y-ECXVi6KCusbMKhkER65drbPSZHt_LRn5BBURbuKaE-ly6LRQqwM-WRijRyZmvfAozSqZPOI6-7b5uYtuc5Um98TerYJ4oS1ETSasIj2730sun18Re5jVZNV2IB4CJfeWSEakvQOMA4BpaqSXYERzo3AMoe2WrV-Z_7jzpdJ61FWSVX898jr_rTOABWyRWuPK9lZMwjzuFBNpqp0Q8UBjFyX8DV8sak6QWwz_jNM0V-WvcblwCZwbRv_vuxXpI7sCCTjwfzw2fkLr5Pk6kakUH1_dw9B-xWpS_aRULJyW2vy1_501dB |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Prooxidant+Effects+of+Epigallocatechin-3-Gallate+in+Health+Benefits+and+Potential+Adverse+Effect&rft.jtitle=Oxidative+medicine+and+cellular+longevity&rft.au=Ouyang%2C+Jie&rft.au=Zhu%2C+Kun&rft.au=Liu%2C+Zhonghua&rft.au=Huang%2C+Jianan&rft.date=2020&rft.pub=John+Wiley+%26+Sons%2C+Inc&rft.issn=1942-0900&rft.volume=2020&rft_id=info:doi/10.1155%2F2020%2F9723686&rft.externalDocID=A640831932 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1942-0900&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1942-0900&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1942-0900&client=summon |