Anti-Inflammatory Effects of p-Coumaric Acid, a Natural Compound of Oldenlandia diffusa, on Arthritis Model Rats

• Published in: Evidence-based complementary and alternative medicine Vol. 2018; no. 2018; pp. 1 - 9
• Main Authors: Wu, Dan, Sun, Mei-juan, Zhang, Zhi-hui, Wang, Yang, Xiong, Xin-Gui, Liang, Qing-hua, Zhu, Hao, Lu, Xun
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2018; Hindawi; John Wiley & Sons, Inc
• Subjects: Acids; Anti-inflammatory agents; Anti-inflammatory drugs; Antiarthritic agents; Arthritis; Atherosclerosis; Chromatography; Collagen; Coumaric acid; Cytokines; Drug dosages; Fibroblasts; Herbs; Immunology; Inflammation; Interleukin 6; Joint diseases; Laboratory animals; Liquid chromatography; Oldenlandia; p-Coumaric acid; Rheumatoid arthritis; Rheumatoid factor; Rheumatology; Rodents; Serum levels; Tumor necrosis factor; Tumor necrosis factor-α; China

Objectives. In China, Oldenlandia diffusa (OD) is a natural herb that is widely used and has been proven to be effective in the treatment of rheumatoid arthritis (RA). This study aimed to preliminarily reveal the mechanism by which OD exerts its beneficial effect. Methods. Ultra-performance liquid c...