Phosphorylation independent eIF4E translational reprogramming of selective mRNAs determines tamoxifen resistance in breast cancer

• Published in: Oncogene Vol. 39; no. 15; pp. 3206 - 3217
• Main Authors: Gong, Chun, Tsoi, Ho, Mok, Ka Chun, Cheung, Jenny, Man, Ellen P. S., Fujino, Kazunari, Wong, Ashely, Lam, Eric W. F., Khoo, Ui-Soon
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.04.2020; Nature Publishing Group
• Subjects: 13/106; 13/109; 13/51; 13/89; 38/39; 38/77; 38/90; 38/91; 631/67/1347; 631/67/1857; 631/80/86; Antiestrogens; Apoptosis; Breast - pathology; Breast - surgery; Breast cancer; Breast Neoplasms - genetics; Breast Neoplasms - pathology; Breast Neoplasms - therapy; Cell Biology; Cell Line, Tumor; Cellular proteins; Chemotherapy, Adjuvant - methods; Development and progression; Drug resistance; Drug Resistance, Neoplasm - genetics; Drug therapy; Estrogen Receptor alpha - genetics; Estrogen receptors; Estrogens; Eukaryotic Initiation Factor-4E - genetics; Eukaryotic Initiation Factor-4E - metabolism; Female; Follow-Up Studies; Forkhead Box Protein M1 - genetics; Gene expression; Gene Expression Regulation, Neoplastic; Gene Knockdown Techniques; Genetic aspects; Genomes; Health aspects; Human Genetics; Humans; Immunohistochemistry; Initiation factor eIF-4E; Internal Medicine; Mastectomy; MCF-7 Cells; Medicine; Medicine & Public Health; Messenger RNA; Oncology; Patient outcomes; Phosphorylation; Protein Biosynthesis; RNA, Messenger - metabolism; RNA-Seq; Signal transduction; Tamoxifen; Tamoxifen - pharmacology; Tamoxifen - therapeutic use; Transcription; Transcriptomes; Hong Kong, China

Eukaryotic translation initiation factor 4E (eIF4E) selectively promotes translation of mRNAs with atypically long and structured 5′-UTRs and has been implicated in drug resistance. Through genome-wide transcriptome and translatome analysis we revealed eIF4E overexpression could promote cellular act...