Phenolic Compound Ethyl 3,4-Dihydroxybenzoate Retards Drug Efflux and Potentiates Antibiotic Activity

• Published in: Antibiotics (Basel) Vol. 11; no. 4; p. 497
• Main Authors: Lu, Wen-Jung, Huang, Yan-Jyun, Lin, Hsuan-Ju, Chang, Chun-Ju, Hsu, Pang-Hung, Ooi, Gui-Xia, Huang, Mei-Ying, Lin, Hong-Ting Victor
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 08.04.2022; MDPI
• Subjects: Accumulation; Antibacterial activity; Antibiotic resistance; Antibiotics; Bacteria; Bacterial infections; Drug resistance; drug transporters; Dyes; E coli; Efflux; efflux pump inhibitors; Escherichia coli; ethyl 3,4-dihydroxybenzoate; Food security; Gram-negative bacteria; Gram-positive bacteria; Health risks; Hydrophobicity; Membrane permeability; Molecular docking; multidrug resistance; Pathogens; Phenolic compounds; Phenols; Substrates; Toxicity; Translocation; drug transporters; phenolic compounds; multidrug resistance; molecular docking; efflux pump inhibitors; ethyl 3,4-dihydroxybenzoate

The World Health Organization indicated that antibiotic resistance is one of the greatest threats to health, food security, and development in the world. Drug resistance efflux pumps are essential for antibiotic resistance in bacteria. Here, we evaluated the plant phenolic compound ethyl 3,4-dihydro...