Rapid Structure Determination of Ranitidine Hydrochloride API in Two Crystal Forms Using Microcrystal Electron Diffraction

• Published in: Chemical & pharmaceutical bulletin Vol. 72; no. 5; pp. 471 - 474
• Main Authors: Yokoo, Hidetomo, Aoyama, Yoshitaka, Matsumoto, Takashi, Yamamoto, Eiichi, Uchiyama, Nahoko, Demizu, Yosuke
• Format: Journal Article
• Language: English
• Published: Japan The Pharmaceutical Society of Japan 2024; Japan Science and Technology Agency
• Subjects: Active control; active pharmaceutical ingredient; crystal polymorphism; Crystallization; Crystallography; Crystals; Drug development; Electron diffraction; Electrons; microcrystal electron diffraction; Microcrystals; Molecular Structure; Quality control; Ranitidine; Ranitidine - chemistry; Ranitidine hydrochloride; Single crystals; Structural analysis; X-ray diffraction; crystal polymorphism; microcrystal electron diffraction; active pharmaceutical ingredient; ranitidine hydrochloride

The solid-state properties of drug candidates play a crucial role in their selection. Quality control of active pharmaceutical ingredients (APIs) based on their structural information involves ensuring a consistent crystal form and controlling water and residual solvent contents. However, traditiona...