Signal transduction regulates schistosome reproductive biology
Schistosome parasites exhibit separate sexes and with the evolution of sex they have developed an intricate relationship between the male and female worms such that signals between the male and female that are initiated at the time of mating, regulate female reproductive development and subsequent e...
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| Published in | Current opinion in microbiology Vol. 12; no. 4; pp. 422 - 428 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
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Elsevier Ltd
01.08.2009
Elsevier |
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| Abstract | Schistosome parasites exhibit separate sexes and with the evolution of sex they have developed an intricate relationship between the male and female worms such that signals between the male and female that are initiated at the time of mating, regulate female reproductive development and subsequent egg production. As the egg stage is responsible for pathogenesis and transmission, understanding the molecular mechanisms of female reproductive development may identify novel targets for the control of transmission and morbidity of this major world public health problem. Recent data have demonstrated that the pairing process, proliferation, and differentiation of vitelline cells, expression of female-specific genes and egg embryogenesis are regulated by the TGFβ pathway and protein tyrosine kinases. |
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| AbstractList | Schistosome parasites exhibit separate sexes and with the evolution of sex they have developed an intricate relationship between the male and female worms such that signals between the male and female that are initiated at the time of mating, regulate female reproductive development and subsequent egg production. As the egg stage is responsible for pathogenesis and transmission, understanding the molecular mechanisms of female reproductive development may identify novel targets for control of transmission and morbidity of this major world public health problem. Recent data has demonstrated that the pairing process, proliferation and differentiation of vitelline cells, expression of female-specific genes and egg embryogenesis are regulated by the TGFβ pathway and protein tyrosine kinases. Schistosome parasites exhibit separate sexes and with the evolution of sex they have developed an intricate relationship between the male and female worms such that signals between the male and female that are initiated at the time of mating, regulate female reproductive development and subsequent egg production. As the egg stage is responsible for pathogenesis and transmission, understanding the molecular mechanisms of female reproductive development may identify novel targets for the control of transmission and morbidity of this major world public health problem. Recent data have demonstrated that the pairing process, proliferation, and differentiation of vitelline cells, expression of female-specific genes and egg embryogenesis are regulated by the TGFb pathway and protein tyrosine kinases. Schistosome parasites exhibit separate sexes and with the evolution of sex they have developed an intricate relationship between the male and female worms such that signals between the male and female that are initiated at the time of mating, regulate female reproductive development and subsequent egg production. As the egg stage is responsible for pathogenesis and transmission, understanding the molecular mechanisms of female reproductive development may identify novel targets for the control of transmission and morbidity of this major world public health problem. Recent data have demonstrated that the pairing process, proliferation, and differentiation of vitelline cells, expression of female-specific genes and egg embryogenesis are regulated by the TGFβ pathway and protein tyrosine kinases. Schistosome parasites exhibit separate sexes and with the evolution of sex they have developed an intricate relationship between the male and female worms such that signals between the male and female that are initiated at the time of mating, regulate female reproductive development and subsequent egg production. As the egg stage is responsible for pathogenesis and transmission, understanding the molecular mechanisms of female reproductive development may identify novel targets for the control of transmission and morbidity of this major world public health problem. Recent data have demonstrated that the pairing process, proliferation, and differentiation of vitelline cells, expression of female-specific genes and egg embryogenesis are regulated by the TGFbeta pathway and protein tyrosine kinases. |
| Author | LoVerde, Philip T Oliveira, Guilherme Andrade, Luiza F |
| AuthorAffiliation | 1 Departments of Biochemistry and Pathology University of Texas Health Science Center 7703 Flyod Curl Dr., San Antonio, Texas 78229 2 Centro de Pesquisas Rene Rachou/CPqRR, FIOCRUZ Av. Augusto de Lima 1715, Belo Horizonte, MG, 30190-002, Brazil Tel: +55-31-3349-7785, luizafreire@cpqrr.fiocruz.br , oliveira@cpqrr.fiocruz.br |
| AuthorAffiliation_xml | – name: 2 Centro de Pesquisas Rene Rachou/CPqRR, FIOCRUZ Av. Augusto de Lima 1715, Belo Horizonte, MG, 30190-002, Brazil Tel: +55-31-3349-7785, luizafreire@cpqrr.fiocruz.br , oliveira@cpqrr.fiocruz.br – name: 1 Departments of Biochemistry and Pathology University of Texas Health Science Center 7703 Flyod Curl Dr., San Antonio, Texas 78229 |
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| SubjectTerms | Animals Biological and medical sciences Cell Differentiation Female Fundamental and applied biological sciences. Psychology Gene Expression Regulation, Developmental Life Cycle Stages Male Microbiology Models, Biological Pathology Protein-Tyrosine Kinases - metabolism Schistosoma - growth & development Signal Transduction Transforming Growth Factor beta - metabolism |
| Title | Signal transduction regulates schistosome reproductive biology |
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