The Signaling of Cellular Senescence in Diabetic Nephropathy

• Published in: Oxidative medicine and cellular longevity Vol. 2019; no. 2019; pp. 1 - 16
• Main Authors: Xiong, Yabing, Zhou, Lili
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2019; Hindawi; John Wiley & Sons, Inc
• Subjects: Aging; Animals; B cells; Cardiovascular diseases; Cell cycle; Cell division; Cellular Senescence; Chronic kidney failure; CRISPR; Cyclin-dependent kinases; Cytokines; Development and progression; Diabetes; Diabetic nephropathies; Diabetic Nephropathies - genetics; Diabetic Nephropathies - metabolism; Diabetic Nephropathies - pathology; Diabetic Nephropathies - therapy; Diabetic nephropathy; DNA Damage; Epigenesis, Genetic; Epigenetic inheritance; Fenofibrate; Glucose; Health aspects; Hemodialysis; Humans; Hyperglycemia; Inflammation; Kidney diseases; Kinases; Medical research; Mitophagy; Nephrology; Oxidative stress; Proteins; Review; Senescence; Signal Transduction; Stem cells; Systematic review; Telomeres; Tumor necrosis factor-TNF; Type 2 diabetes; China

Diabetic nephropathy is the leading cause of chronic kidney disease (CKD) in western countries. Notably, it has a rapidly rising prevalence in China. The patients, commonly complicated with cardiovascular diseases and neurologic disorders, are at high risk to progress into end-stage renal disease (E...