UDP-glucose 6-dehydrogenase regulates hyaluronic acid production and promotes breast cancer progression

• Published in: Oncogene Vol. 39; no. 15; pp. 3089 - 3101
• Main Authors: Arnold, James M., Gu, Franklin, Ambati, Chandrashekar R., Rasaily, Uttam, Ramirez-Pena, Esmeralda, Joseph, Robiya, Manikkam, Mohan, San Martin, Rebeca, Charles, Christy, Pan, Yinghong, Chatterjee, Sujash S., Den Hollander, Petra, Zhang, Weijie, Nagi, Chandandeep, Sikora, Andrew G., Rowley, David, Putluri, Nagireddy, Zhang, Xiang H.-F., Karanam, Balasubramanyam, Mani, Sendurai A., Sreekumar, Arun
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 09.04.2020; Nature Publishing Group
• Subjects: 101/58; 13/51; 13/89; 14/1; 14/19; 38/39; 38/77; 59/5; 631/45/221; 631/67/1347; 631/67/2327; 631/67/327; 64/60; Acid production; Acids; Animals; Apoptosis; Breast - pathology; Breast cancer; Breast Neoplasms - pathology; Care and treatment; Cell Biology; Cell Line, Tumor; Chick Embryo; Chorioallantoic Membrane; Development and progression; Disease Progression; Epithelial-Mesenchymal Transition; Extracellular matrix; Extracellular Matrix - pathology; Female; Gene expression; Gene Knockdown Techniques; Genetic aspects; Glucose metabolism; Health aspects; Human Genetics; Humans; Hyaluronic acid; Hyaluronic Acid - biosynthesis; Internal Medicine; Medicine; Medicine & Public Health; Mesenchyme; Metabolism; Metastases; Metastasis; Oncogenes; Oncology; Peroxisome proliferator-activated receptors; PPAR gamma - metabolism; RNA-Seq; Tissue Array Analysis; UDP-glucose 6-dehydrogenase; Uridine Diphosphate Glucose Dehydrogenase - genetics; Uridine Diphosphate Glucose Dehydrogenase - metabolism; Uridine Diphosphate Glucuronic Acid - metabolism; Xenograft Model Antitumor Assays; United States

An improved understanding of the biochemical alterations that accompany tumor progression and metastasis is necessary to inform the next generation of diagnostic tools and targeted therapies. Metabolic reprogramming is known to occur during the epithelial–mesenchymal transition (EMT), a process that...