Anti‐EF‐Tu IgG titers increase with age and may contribute to protection against the respiratory pathogen Haemophilus influenzae

• Published in: European journal of immunology Vol. 49; no. 3; pp. 490 - 499
• Main Authors: Thofte, Oskar, Kaur, Ravinder, Su, Yu‐Ching, Brant, Marta, Rudin, Anna, Hood, Derek, Riesbeck, Kristian
• Format: Journal Article
• Language: English
• Published: Germany Wiley Subscription Services, Inc 01.03.2019; John Wiley and Sons Inc
• Subjects: Adult; Age; Age Factors; Animals; Antibodies, Bacterial - administration & dosage; Antibodies, Bacterial - immunology; Antibodies, Bacterial - metabolism; Bacteria; Bacterial infections; Basic Medicine; Child; Child, Preschool; Children; Chronic obstructive pulmonary disease; Clinical; Clinical Medicine; Epitope mapping; Haemophilus Infections - immunology; Haemophilus Infections - microbiology; Haemophilus Infections - prevention & control; Haemophilus influenzae; Haemophilus influenzae - drug effects; Haemophilus influenzae - immunology; Haemophilus influenzae - physiology; Humans; Immune response; Immunity to infection; Immunization; Immunoglobulin G; Immunoglobulin G - administration & dosage; Immunoglobulin G - immunology; Immunoglobulin G - metabolism; Infant; Infections; Klinisk medicin; Lung diseases; Lungmedicin och allergi; Medical and Health Sciences; Medicin och hälsovetenskap; Medicinska och farmaceutiska grundvetenskaper; Mice; Mice, Inbred BALB C; Mice, Inbred C3H; Mice, Inbred C57BL; Microbiology in the medical area; Middle ear; Mikrobiologi inom det medicinska området; Morbidity; Mucosal immunity; Nasopharynx; Obstructive lung disease; Otitis media; Otitis Media - immunology; Otitis Media - microbiology; Pathogens; Pediatrics; Pediatrik; Peptide Elongation Factor Tu - immunology; Peptide Elongation Factor Tu - metabolism; Peptide mapping; Protein biosynthesis; Protein synthesis; Respiratory Medicine and Allergy; Respiratory System - drug effects; Respiratory System - immunology; Respiratory System - microbiology; Surface antigen; Epitope mapping; Surface antigen; Chronic obstructive pulmonary disease; Bacterial infections; Mucosal immunity

Non‐typeable Haemophilus influenzae (NTHi) is a pathogen that commonly colonizes the nasopharynx of preschool children, causing opportunistic infections including acute otitis media (AOM). Patients suffering from chronic obstructive pulmonary disease (COPD) are persistently colonized with NTHi and o...