Cooperative functions of manganese and thiol redox system against oxidative stress in human spermatozoa
In this study, the effects of 0.1 mM Mn 2+ on thiol components (total thiols [TSH], glutathione reduced [GSH], glutathione oxidized [GSSG] and redox ratio [GSH/ GSSG]) have been determined in human spermatozoa. The subjects of the study were healthy males having more than 75% motility and 80 x 10 6...
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| Published in | Journal of human reproductive sciences Vol. 2; no. 2; pp. 76 - 80 |
|---|---|
| Main Authors | , |
| Format | Journal Article |
| Language | English |
| Published |
India
Medknow Publications and Media Pvt. Ltd
01.07.2009
Medknow Publications & Media Pvt. Ltd Medknow Publications Wolters Kluwer Medknow Publications |
| Subjects | |
| Online Access | Get full text |
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| Abstract | In this study, the effects of 0.1 mM Mn 2+ on thiol components (total thiols [TSH], glutathione reduced [GSH], glutathione oxidized [GSSG] and redox ratio [GSH/ GSSG]) have been determined in human spermatozoa.
The subjects of the study were healthy males having more than 75% motility and 80 x 10 6 sperms/mL.
Fresh semen was suspended in phosphate-buffered saline (PBS) (pH 7.2) and this suspension was divided into eight equal fractions. All fractions, control (containing PBS) and experimental (treated/untreated with [ferrous ascorbate, FeAA - 200 FeSO 4 muM, 1000 muM ascorbic acid, nicotine (0.5 mM) and FeAA + nicotine], supplemented/unsupplemented with Mn 2+ [0.1 mM]), were incubated for 2 h at 378C. These fractions were assessed for determining the thiol components.
The data were statistically analyzed by Students " t" test.
Ferrous ascorbate, nicotine and ferrous ascorbate + nicotine induced oxidative stress and decreased GSH and redox ratio (GSH/GSSG ratio) but increased the TSH and GSSG levels. Mn 2+ supplementation improved TSH, GSH and redox ratio (GSH/GSSG) but decreased the GSSG level under normal and oxidative stress conditions. Thiol groups serve as defense mechanisms of sperm cells to fight against oxidative stress induced by stress inducers such as ferrous ascorbate, nicotine and their combination (ferrous ascorbate + nicotine). In addition, Mn 2+ supplementation maintains the thiol level by reducing oxidative stress. |
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| AbstractList | Aims: In this study, the effects of 0.1 mM Mn 2+ on thiol components (total thiols [TSH], glutathione reduced [GSH], glutathione oxidized [GSSG] and redox ratio [GSH/ GSSG]) have been determined in human spermatozoa. Settings and Design: The subjects of the study were healthy males having more than 75% motility and 80 x 10 6 sperms/mL. Materials and Methods: Fresh semen was suspended in phosphate-buffered saline (PBS) (pH 7.2) and this suspension was divided into eight equal fractions. All fractions, control (containing PBS) and experimental (treated/untreated with [ferrous ascorbate, FeAA - 200 FeSO 4 μM, 1000 μM ascorbic acid, nicotine (0.5 mM) and FeAA + nicotine], supplemented/unsupplemented with Mn 2+ [0.1 mM]), were incubated for 2 h at 378C. These fractions were assessed for determining the thiol components. Statistical Analysis: The data were statistically analyzed by Students " t" test. Results and Conclusions: Ferrous ascorbate, nicotine and ferrous ascorbate + nicotine induced oxidative stress and decreased GSH and redox ratio (GSH/GSSG ratio) but increased the TSH and GSSG levels. Mn 2+ supplementation improved TSH, GSH and redox ratio (GSH/GSSG) but decreased the GSSG level under normal and oxidative stress conditions. Thiol groups serve as defense mechanisms of sperm cells to fight against oxidative stress induced by stress inducers such as ferrous ascorbate, nicotine and their combination (ferrous ascorbate + nicotine). In addition, Mn 2+ supplementation maintains the thiol level by reducing oxidative stress. In this study, the effects of 0.1 mM Mn 2+ on thiol components (total thiols [TSH], glutathione reduced [GSH], glutathione oxidized [GSSG] and redox ratio [GSH/ GSSG]) have been determined in human spermatozoa. The subjects of the study were healthy males having more than 75% motility and 80 x 10 6 sperms/mL. Fresh semen was suspended in phosphate-buffered saline (PBS) (pH 7.2) and this suspension was divided into eight equal fractions. All fractions, control (containing PBS) and experimental (treated/untreated with [ferrous ascorbate, FeAA - 200 FeSO 4 muM, 1000 muM ascorbic acid, nicotine (0.5 mM) and FeAA + nicotine], supplemented/unsupplemented with Mn 2+ [0.1 mM]), were incubated for 2 h at 378C. These fractions were assessed for determining the thiol components. The data were statistically analyzed by Students " t" test. Ferrous ascorbate, nicotine and ferrous ascorbate + nicotine induced oxidative stress and decreased GSH and redox ratio (GSH/GSSG ratio) but increased the TSH and GSSG levels. Mn 2+ supplementation improved TSH, GSH and redox ratio (GSH/GSSG) but decreased the GSSG level under normal and oxidative stress conditions. Thiol groups serve as defense mechanisms of sperm cells to fight against oxidative stress induced by stress inducers such as ferrous ascorbate, nicotine and their combination (ferrous ascorbate + nicotine). In addition, Mn 2+ supplementation maintains the thiol level by reducing oxidative stress. Aims: In this study, the effects of 0.1 mM Mn2+ on thiol components (total thiols [TSH], glutathione reduced [GSH], glutathione oxidized [GSSG] and redox ratio [GSH/ GSSG]) have been determined in human spermatozoa. Settings and Design: The subjects of the study were healthy males having more than 75% motility and 80 x 106 sperms/mL. Materials and Methods: Fresh semen was suspended in phosphate-buffered saline (PBS) (pH 7.2) and this suspension was divided into eight equal fractions. All fractions, control (containing PBS) and experimental (treated/untreated with [ferrous ascorbate, FeAA - 200 FeSO4 μM, 1000 μM ascorbic acid, nicotine (0.5 mM) and FeAA + nicotine], supplemented/unsupplemented with Mn2+ [0.1 mM]), were incubated for 2 h at 378C. These fractions were assessed for determining the thiol components. Statistical Analysis: The data were statistically analyzed by Students " t" test. Results and Conclusions: Ferrous ascorbate, nicotine and ferrous ascorbate + nicotine induced oxidative stress and decreased GSH and redox ratio (GSH/GSSG ratio) but increased the TSH and GSSG levels. Mn2+ supplementation improved TSH, GSH and redox ratio (GSH/GSSG) but decreased the GSSG level under normal and oxidative stress conditions. Thiol groups serve as defense mechanisms of sperm cells to fight against oxidative stress induced by stress inducers such as ferrous ascorbate, nicotine and their combination (ferrous ascorbate + nicotine). In addition, Mn2+ supplementation maintains the thiol level by reducing oxidative stress. |
| Audience | Academic |
| Author | Kaur, AnandRavinder Jit Bansal, AmritKaur |
| AuthorAffiliation | 1 Department of Zoology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab University, Chandigarh, India Department of Animal Reproduction, Gynaecology and Obstetrics, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab University, Chandigarh, India |
| AuthorAffiliation_xml | – name: Department of Animal Reproduction, Gynaecology and Obstetrics, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab University, Chandigarh, India – name: 1 Department of Zoology, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab University, Chandigarh, India |
| Author_xml | – sequence: 1 givenname: AmritKaur surname: Bansal fullname: Bansal, AmritKaur – sequence: 2 givenname: AnandRavinder Jit surname: Kaur fullname: Kaur, AnandRavinder Jit |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19881153$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Health aspects Human sperm Mn 2 Original Oxidative stress Physiological aspects Prevention Risk factors Spermatozoa Thiols |
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| Title | Cooperative functions of manganese and thiol redox system against oxidative stress in human spermatozoa |
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