Use of Coated Silver Nanoparticles to Understand the Relationship of Particle Dissolution and Bioavailability to Cell and Lung Toxicological Potential

• Published in: Small (Weinheim an der Bergstrasse, Germany) Vol. 10; no. 2; pp. 385 - 398
• Main Authors: Wang, Xiang, Ji, Zhaoxia, Chang, Chong Hyun, Zhang, Haiyuan, Wang, Meiying, Liao, Yu-Pei, Lin, Sijie, Meng, Huan, Li, Ruibin, Sun, Bingbing, Winkle, Laura Van, Pinkerton, Kent E., Zink, Jeffrey I., Xia, Tian, Nel, André E.
• Format: Journal Article
• Language: English
• Published: Germany Blackwell Publishing Ltd 29.01.2014; Wiley Subscription Services, Inc
• Subjects: Animals; Biocompatibility; Biological Availability; Cell Line; Citrates; cytotoxicity; Dissolution; Female; Humans; Lung - drug effects; lung inflammation; Lungs; Male; Metal Nanoparticles - chemistry; Metal Nanoparticles - toxicity; Mice; Microscopy, Electron, Transmission; nanoparticle; Nanoparticles; Nanostructure; Nanotechnology; Rats; Silver; Silver - chemistry; Silver - pharmacokinetics; Silver - toxicity; Solubility; Toxicity; Toxicity Tests, Subchronic; nanoparticle; silver; cytotoxicity; dissolution; lung inflammation
• ISSN: 1613-6810; 1613-6829; 1613-6829
• DOI: 10.1002/smll.201301597

Since more than 30% of consumer products that include engineered nanomaterials contain nano‐Ag, the safety of this material is of considerable public concern. In this study, Ag nanoparticles (NPs) are used to demonstrate that 20 nm polyvinylpyrrolidone (PVP or P) and citrate (C)‐coated Ag NPs induce...