Increased plasma LIGHT levels in patients with atopic dermatitis

• Published in: Clinical and experimental immunology Vol. 168; no. 3; pp. 318 - 324
• Main Authors: Kotani, H., Masuda, K., Tamagawa‐Mineoka, R., Nomiyama, T., Soga, F., Nin, M., Asai, J., Kishimoto, S., Katoh, N.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.06.2012; Blackwell; Oxford University Press
• Subjects: Adult; Allergic diseases; Analytical, structural and metabolic biochemistry; Apoptosis; Apoptosis - drug effects; Atopic dermatitis; B7-2 Antigen - genetics; B7-2 Antigen - metabolism; Bcl-2 protein; Biological and medical sciences; biomarkers; Biomarkers - blood; Caspase-3; CCL17 protein; CD86 antigen; Cell Line, Tumor; Chemokine CCL17 - blood; Dermatitis; Dermatitis, Atopic - blood; Dermatitis, Atopic - immunology; Disease Progression; Drug therapy; Eosinophils - drug effects; Eosinophils - pathology; Female; Fundamental and applied biological sciences. Psychology; glycoprotein D; Herpes simplex virus; Humans; Immunoglobulin E; Immunoglobulin E - blood; Immunopathology; Inflammatory diseases; Interleukin 1; Interleukin-1beta - genetics; Interleukin-1beta - metabolism; Leukocytes (eosinophilic); LIGHT; LIGHT protein; Lymphocytes T; Lymphotoxin; Male; Medical sciences; Middle Aged; Monocytes; Monocytes - drug effects; Monocytes - immunology; Original; Peripheral blood; Plasma; Proto-Oncogene Proteins c-bcl-2 - genetics; Proto-Oncogene Proteins c-bcl-2 - metabolism; Skin allergic diseases. Stinging insect allergies; THP‐1; Tumor necrosis factor; Tumor Necrosis Factor Ligand Superfamily Member 14 - blood; Tumor Necrosis Factor Ligand Superfamily Member 14 - pharmacology; Up-Regulation; Young Adult; Human; Allergy; Immunopathology; THP-1; Skin disease; Atopic dermatitis; LIGHT; LIGHT ligand; Biochemistry; Atopy; Blood plasma

Summary LIGHT [the name of which is derived from ‘homologous to lymphotoxins, exhibits inducible expression, competes with herpes simplex virus glycoprotein D for herpes simplex virus entry mediator (HVEM), and expressed by T lymphocytes’], is a member of the tumour necrosis factor superfamily that...