Immune responses against islet allografts during tapering of immunosuppression – a pilot study in 5 subjects
Summary Transplantation of isolated islet of Langerhans cells has great potential as a cure for type 1 diabetes but continuous immune suppressive therapy often causes considerable side effects. Tapering of immunosuppression in successfully transplanted patients would lower patients' health risk...
Saved in:
| Published in | Clinical and experimental immunology Vol. 169; no. 2; pp. 190 - 198 |
|---|---|
| Main Authors | , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford, UK
Blackwell Publishing Ltd
01.08.2012
Blackwell Oxford University Press Blackwell Science Inc |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | Summary
Transplantation of isolated islet of Langerhans cells has great potential as a cure for type 1 diabetes but continuous immune suppressive therapy often causes considerable side effects. Tapering of immunosuppression in successfully transplanted patients would lower patients' health risk. To identify immune biomarkers that may prove informative in monitoring tapering, we studied the effect of tapering on islet auto‐ and alloimmune reactivity in a pilot study in five transplant recipients in vitro. Cytokine responses to the graft were measured using Luminex technology. Avidity of alloreactive cytotoxic T Lymphocytes (CTL) was determined by CD8 blockade. The influence of immunosuppression was mimicked by in vitro replenishment of tacrolimus and MPA, the active metabolite of mycophenolate mofetil. Tapering of tacrolimus was generally followed by decreased C‐peptide production. T‐cell autoreactivity increased in four out of five patients during tapering. Overall alloreactive CTL precursor frequencies did not change, but their avidity to donor mismatches increased significantly after tapering (P = 0·035). In vitro addition of tacrolimus but not MPA strongly inhibited CTL alloreactivity during tapering and led to a significant shift to anti‐inflammatory graft‐specific cytokine production. Tapering of immunosuppression is characterized by diverse immune profiles that appear to relate inversely to plasma C‐peptide levels. Highly avid allospecific CTLs that are known to associate with rejection increased during tapering, but could be countered by restoring immune suppression in vitro. Immune monitoring studies may help guiding tapering of immunosuppression after islet cell transplantation, even though we do not have formal prove yet that the observed changes reflect direct effects of immune suppression on immunity. |
|---|---|
| AbstractList | Summary
Transplantation of isolated islet of Langerhans cells has great potential as a cure for type 1 diabetes but continuous immune suppressive therapy often causes considerable side effects. Tapering of immunosuppression in successfully transplanted patients would lower patients' health risk. To identify immune biomarkers that may prove informative in monitoring tapering, we studied the effect of tapering on islet auto‐ and alloimmune reactivity in a pilot study in five transplant recipients in vitro. Cytokine responses to the graft were measured using Luminex technology. Avidity of alloreactive cytotoxic T Lymphocytes (CTL) was determined by CD8 blockade. The influence of immunosuppression was mimicked by in vitro replenishment of tacrolimus and MPA, the active metabolite of mycophenolate mofetil. Tapering of tacrolimus was generally followed by decreased C‐peptide production. T‐cell autoreactivity increased in four out of five patients during tapering. Overall alloreactive CTL precursor frequencies did not change, but their avidity to donor mismatches increased significantly after tapering (P = 0·035). In vitro addition of tacrolimus but not MPA strongly inhibited CTL alloreactivity during tapering and led to a significant shift to anti‐inflammatory graft‐specific cytokine production. Tapering of immunosuppression is characterized by diverse immune profiles that appear to relate inversely to plasma C‐peptide levels. Highly avid allospecific CTLs that are known to associate with rejection increased during tapering, but could be countered by restoring immune suppression in vitro. Immune monitoring studies may help guiding tapering of immunosuppression after islet cell transplantation, even though we do not have formal prove yet that the observed changes reflect direct effects of immune suppression on immunity. Transplantation of isolated islet of Langerhans cells has great potential as a cure for type 1 diabetes but continuous immune suppressive therapy often causes considerable side effects. Tapering of immunosuppression in successfully transplanted patients would lower patients' health risk. To identify immune biomarkers that may prove informative in monitoring tapering, we studied the effect of tapering on islet auto- and alloimmune reactivity in a pilot study in five transplant recipients in vitro. Cytokine responses to the graft were measured using Luminex technology. Avidity of alloreactive cytotoxic T Lymphocytes (CTL) was determined by CD8 blockade. The influence of immunosuppression was mimicked by in vitro replenishment of tacrolimus and MPA, the active metabolite of mycophenolate mofetil. Tapering of tacrolimus was generally followed by decreased C-peptide production. T-cell autoreactivity increased in four out of five patients during tapering. Overall alloreactive CTL precursor frequencies did not change, but their avidity to donor mismatches increased significantly after tapering (P = 0·035). In vitro addition of tacrolimus but not MPA strongly inhibited CTL alloreactivity during tapering and led to a significant shift to anti-inflammatory graft-specific cytokine production. Tapering of immunosuppression is characterized by diverse immune profiles that appear to relate inversely to plasma C-peptide levels. Highly avid allospecific CTLs that are known to associate with rejection increased during tapering, but could be countered by restoring immune suppression in vitro. Immune monitoring studies may help guiding tapering of immunosuppression after islet cell transplantation, even though we do not have formal prove yet that the observed changes reflect direct effects of immune suppression on immunity. Transplantation of isolated islet of Langerhans cells has great potential as a cure for type 1 diabetes but continuous immune suppressive therapy often causes considerable side effects. Tapering of immunosuppression in successfully transplanted patients would lower patients' health risk. To identify immune biomarkers that may prove informative in monitoring tapering, we studied the effect of tapering on islet auto- and alloimmune reactivity in a pilot study in five transplant recipients in vitro. Cytokine responses to the graft were measured using Luminex technology. Avidity of alloreactive cytotoxic T Lymphocytes (CTL) was determined by CD8 blockade. The influence of immunosuppression was mimicked by in vitro replenishment of tacrolimus and MPA, the active metabolite of mycophenolate mofetil. Tapering of tacrolimus was generally followed by decreased C-peptide production. T-cell autoreactivity increased in four out of five patients during tapering. Overall alloreactive CTL precursor frequencies did not change, but their avidity to donor mismatches increased significantly after tapering (P = 0·035). In vitro addition of tacrolimus but not MPA strongly inhibited CTL alloreactivity during tapering and led to a significant shift to anti-inflammatory graft-specific cytokine production. Tapering of immunosuppression is characterized by diverse immune profiles that appear to relate inversely to plasma C-peptide levels. Highly avid allospecific CTLs that are known to associate with rejection increased during tapering, but could be countered by restoring immune suppression in vitro. Immune monitoring studies may help guiding tapering of immunosuppression after islet cell transplantation, even though we do not have formal prove yet that the observed changes reflect direct effects of immune suppression on immunity.Transplantation of isolated islet of Langerhans cells has great potential as a cure for type 1 diabetes but continuous immune suppressive therapy often causes considerable side effects. Tapering of immunosuppression in successfully transplanted patients would lower patients' health risk. To identify immune biomarkers that may prove informative in monitoring tapering, we studied the effect of tapering on islet auto- and alloimmune reactivity in a pilot study in five transplant recipients in vitro. Cytokine responses to the graft were measured using Luminex technology. Avidity of alloreactive cytotoxic T Lymphocytes (CTL) was determined by CD8 blockade. The influence of immunosuppression was mimicked by in vitro replenishment of tacrolimus and MPA, the active metabolite of mycophenolate mofetil. Tapering of tacrolimus was generally followed by decreased C-peptide production. T-cell autoreactivity increased in four out of five patients during tapering. Overall alloreactive CTL precursor frequencies did not change, but their avidity to donor mismatches increased significantly after tapering (P = 0·035). In vitro addition of tacrolimus but not MPA strongly inhibited CTL alloreactivity during tapering and led to a significant shift to anti-inflammatory graft-specific cytokine production. Tapering of immunosuppression is characterized by diverse immune profiles that appear to relate inversely to plasma C-peptide levels. Highly avid allospecific CTLs that are known to associate with rejection increased during tapering, but could be countered by restoring immune suppression in vitro. Immune monitoring studies may help guiding tapering of immunosuppression after islet cell transplantation, even though we do not have formal prove yet that the observed changes reflect direct effects of immune suppression on immunity. Transplantation of isolated islet of Langerhans cells has great potential as a cure for type 1 diabetes but continuous immune suppressive therapy often causes considerable side effects. Tapering of immunosuppression in successfully transplanted patients would lower patients' health risk. To identify immune biomarkers that may prove informative in monitoring tapering, we studied the effect of tapering on islet auto- and alloimmune reactivity in a pilot study in five transplant recipients in vitro. Cytokine responses to the graft were measured using Luminex technology. Avidity of alloreactive cytotoxic T Lymphocytes (CTL) was determined by CD8 blockade. The influence of immunosuppression was mimicked by in vitro replenishment of tacrolimus and MPA, the active metabolite of mycophenolate mofetil. Tapering of tacrolimus was generally followed by decreased C-peptide production. T-cell autoreactivity increased in four out of five patients during tapering. Overall alloreactive CTL precursor frequencies did not change, but their avidity to donor mismatches increased significantly after tapering (P=0.035). In vitro addition of tacrolimus but not MPA strongly inhibited CTL alloreactivity during tapering and led to a significant shift to anti-inflammatory graft-specific cytokine production. Tapering of immunosuppression is characterized by diverse immune profiles that appear to relate inversely to plasma C-peptide levels. Highly avid allospecific CTLs that are known to associate with rejection increased during tapering, but could be countered by restoring immune suppression in vitro. Immune monitoring studies may help guiding tapering of immunosuppression after islet cell transplantation, even though we do not have formal prove yet that the observed changes reflect direct effects of immune suppression on immunity. Summary Transplantation of isolated islet of Langerhans cells has great potential as a cure for type 1 diabetes but continuous immune suppressive therapy often causes considerable side effects. Tapering of immunosuppression in successfully transplanted patients would lower patients' health risk. To identify immune biomarkers that may prove informative in monitoring tapering, we studied the effect of tapering on islet auto- and alloimmune reactivity in a pilot study in five transplant recipients in vitro. Cytokine responses to the graft were measured using Luminex technology. Avidity of alloreactive cytotoxic T Lymphocytes (CTL) was determined by CD8 blockade. The influence of immunosuppression was mimicked by in vitro replenishment of tacrolimus and MPA, the active metabolite of mycophenolate mofetil. Tapering of tacrolimus was generally followed by decreased C-peptide production. T-cell autoreactivity increased in four out of five patients during tapering. Overall alloreactive CTL precursor frequencies did not change, but their avidity to donor mismatches increased significantly after tapering (P = 0·035). In vitro addition of tacrolimus but not MPA strongly inhibited CTL alloreactivity during tapering and led to a significant shift to anti-inflammatory graft-specific cytokine production. Tapering of immunosuppression is characterized by diverse immune profiles that appear to relate inversely to plasma C-peptide levels. Highly avid allospecific CTLs that are known to associate with rejection increased during tapering, but could be countered by restoring immune suppression in vitro. Immune monitoring studies may help guiding tapering of immunosuppression after islet cell transplantation, even though we do not have formal prove yet that the observed changes reflect direct effects of immune suppression on immunity. [PUBLICATION ABSTRACT] Transplantation of isolated islet of Langerhans cells has great potential as a cure for type 1 diabetes but continuous immune suppressive therapy often causes considerable side effects. Tapering of immunosuppression in successfully transplanted patients would lower patients' health risk. To identify immune biomarkers that may prove informative in monitoring tapering, we studied the effect of tapering on islet auto- and alloimmune reactivity in a pilot study in five transplant recipients in vitro . Cytokine responses to the graft were measured using Luminex technology. Avidity of alloreactive cytotoxic T Lymphocytes (CTL) was determined by CD8 blockade. The influence of immunosuppression was mimicked by in vitro replenishment of tacrolimus and MPA, the active metabolite of mycophenolate mofetil. Tapering of tacrolimus was generally followed by decreased C-peptide production. T-cell autoreactivity increased in four out of five patients during tapering. Overall alloreactive CTL precursor frequencies did not change, but their avidity to donor mismatches increased significantly after tapering ( P = 0·035). In vitro addition of tacrolimus but not MPA strongly inhibited CTL alloreactivity during tapering and led to a significant shift to anti-inflammatory graft-specific cytokine production. Tapering of immunosuppression is characterized by diverse immune profiles that appear to relate inversely to plasma C-peptide levels. Highly avid allospecific CTLs that are known to associate with rejection increased during tapering, but could be countered by restoring immune suppression in vitro . Immune monitoring studies may help guiding tapering of immunosuppression after islet cell transplantation, even though we do not have formal prove yet that the observed changes reflect direct effects of immune suppression on immunity. |
| Author | Claas, F. H. J. Roelen, D. L. Duinkerken, G. Hilbrands, R. Gorus, F. K. Gillard, P. Roep, B. O. van der Meer‐Prins, E. P. M. W. Keymeulen, B. van der Torren, C. R. Huurman, V. A. L. Pipeleers, D. G. |
| Author_xml | – sequence: 1 givenname: V. A. L. surname: Huurman fullname: Huurman, V. A. L. – sequence: 2 givenname: C. R. surname: van der Torren fullname: van der Torren, C. R. – sequence: 3 givenname: P. surname: Gillard fullname: Gillard, P. – sequence: 4 givenname: R. surname: Hilbrands fullname: Hilbrands, R. – sequence: 5 givenname: E. P. M. W. surname: van der Meer‐Prins fullname: van der Meer‐Prins, E. P. M. W. – sequence: 6 givenname: G. surname: Duinkerken fullname: Duinkerken, G. – sequence: 7 givenname: F. K. surname: Gorus fullname: Gorus, F. K. – sequence: 8 givenname: F. H. J. surname: Claas fullname: Claas, F. H. J. – sequence: 9 givenname: B. surname: Keymeulen fullname: Keymeulen, B. – sequence: 10 givenname: D. L. surname: Roelen fullname: Roelen, D. L. – sequence: 11 givenname: D. G. surname: Pipeleers fullname: Pipeleers, D. G. – sequence: 12 givenname: B. O. surname: Roep fullname: Roep, B. O. |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26116715$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/22774994$$D View this record in MEDLINE/PubMed |
| BookMark | eNqNUtFuFCEUJabGbqu_YEiMiS-7AgPMzIMmZlN1kya-6DO5wzIrGxZGYGr3zX_wD_0SmXbbap-WkHBv7jmHy-WcoRMfvEEIU7KgZb3dLmglxZwx3i4YoWxBuCRicf0Eze4LJ2hGCGnnLSX8FJ2ltC2plJI9Q6eM1TVvWz5DfrXbjd7gaNIQfDIJwwasTxnb5EzG4FzYROhzwusxWr_BGQZzE4Qe24kc0jgMhZ9s8PjPr98Y8GBdyDjlcb3H1mOB09htjc7pOXrag0vmxeE8R98-Xnxdfp5ffvm0Wn64nGshhZgD6TgwwlrD19D3Je1IDRJA1LTVNe-gr5qm7jjlDQfd9ADAiajXghhKQFfn6P2t7jB2O7PWxucITg3R7iDuVQCr_q94-11twpWqOJFV3RaBNweBGH6MJmW1s0kb58CbMCZFCWvKrrg8Bsp5LTmtCvTVI-g2jNGXSSgquGik4JwV1Mt_m7_v-u7XCuD1AQBJg-sjeG3TA05SKmsqHqagY0gpml5pmyGXfypvtq50piY7qa2aXKMm16jJTurGTuq6CDSPBO7uOIL67pb60zqzP5qnlherKar-AugH4_I |
| CODEN | CEXIAL |
| CitedBy_id | crossref_primary_10_1097_TP_0000000000000682 crossref_primary_10_3389_fmed_2022_932086 crossref_primary_10_1111_ajt_13383 crossref_primary_10_1210_er_2018_00154 crossref_primary_10_1111_dme_12085 crossref_primary_10_1007_s11892_013_0399_3 crossref_primary_10_3727_096368916X693437 crossref_primary_10_1016_j_clim_2013_02_009 crossref_primary_10_2337_db13_0019 crossref_primary_10_3389_fcdhc_2023_1269758 crossref_primary_10_1038_s41598_022_16782_3 crossref_primary_10_1172_JCI93542 crossref_primary_10_1111_ctr_12488 crossref_primary_10_1007_s11892_021_01386_4 crossref_primary_10_3389_fimmu_2023_1112858 crossref_primary_10_2337_db20_0517 crossref_primary_10_1111_cei_12085 crossref_primary_10_1016_j_diabet_2013_10_003 |
| Cites_doi | 10.1056/NEJM199806113382407 10.1038/nri1332 10.2337/db09-1486 10.1097/00007890-199109000-00026 10.2337/diabetes.48.3.484 10.1097/TP.0b013e3181bbee98 10.1111/j.2042-7158.1994.tb03752.x 10.1111/j.1365-2249.2010.04183.x 10.1016/j.critrevonc.2005.03.015 10.1056/NEJMoa061267 10.1073/pnas.0608141103 10.2337/diacare.23.6.838 10.4049/jimmunol.1003868 10.2337/diabetes.54.7.2060 10.2337/db09-0503 10.1111/j.0105-2896.2006.00406.x 10.1016/0020-7101(88)90020-7 10.5414/CPP43379 10.3727/096368909X470874 10.1111/j.1365-2249.2008.03812.x 10.2337/diab.45.12.1814 10.1097/00007890-199204000-00035 10.1111/j.1600-6143.2007.01923.x 10.4049/jimmunol.178.9.5419 10.1002/1098-2752(2000)20:8<420::AID-MICR13>3.0.CO;2-O 10.2337/db06-0173 10.1056/NEJMra033540 10.2337/db09-0160 10.1111/j.0105-2896.2006.00420.x 10.1097/SLA.0b013e3181f3efb0 10.1371/journal.pone.0002435 10.1111/j.1600-6143.2008.02479.x 10.1016/S0022-3565(24)35215-2 10.1097/00007890-199504150-00021 10.1016/j.jhep.2009.03.006 10.1016/S1053-2498(98)00002-3 10.1111/j.1600-6143.2006.01280.x 10.3727/096368909X471198 10.1097/00007890-199311000-00033 10.1111/j.1399-0012.2007.00754.x 10.1097/00007890-199307000-00035 10.1016/0198-8859(92)90015-F 10.2337/db09-0498 10.2337/diabetes.53.12.3107 10.4049/jimmunol.1000560 10.1056/NEJM200007273430401 10.1097/00007890-199559040-00006 |
| ContentType | Journal Article |
| Copyright | 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology 2015 INIST-CNRS 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology. 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology 2012 |
| Copyright_xml | – notice: 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology – notice: 2015 INIST-CNRS – notice: 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology. – notice: 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology 2012 |
| DBID | AAYXX CITATION IQODW CGR CUY CVF ECM EIF NPM 7T5 7U9 H94 M7N 7X8 5PM |
| DOI | 10.1111/j.1365-2249.2012.04605.x |
| DatabaseName | CrossRef Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Immunology Abstracts Virology and AIDS Abstracts AIDS and Cancer Research Abstracts Algology Mycology and Protozoology Abstracts (Microbiology C) MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AIDS and Cancer Research Abstracts Immunology Abstracts Virology and AIDS Abstracts Algology Mycology and Protozoology Abstracts (Microbiology C) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE CrossRef MEDLINE - Academic AIDS and Cancer Research Abstracts AIDS and Cancer Research Abstracts |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1365-2249 |
| EndPage | 198 |
| ExternalDocumentID | PMC3406379 3376870381 22774994 26116715 10_1111_j_1365_2249_2012_04605_x CEI4605 |
| Genre | article Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- .3N .55 .GA .GJ .Y3 05W 0R~ 10A 169 29B 2WC 31~ 36B 3O- 3SF 4.4 50Y 50Z 51W 51X 52M 52N 52O 52P 52R 52S 52T 52U 52V 52W 52X 53G 5GY 5HH 5LA 5VS 5WD 66C 6J9 702 7PT 8-0 8-1 8-3 8-4 8-5 8UM 930 A01 A03 A8Z AABZA AACZT AAESR AAEVG AAFWJ AAMMB AAONW AAPXW AARHZ AAUAY AAVAP AAZKR ABCQN ABCUV ABDBF ABDFA ABEJV ABEML ABGNP ABJNI ABLJU ABNHQ ABOCM ABPTD ABPVW ABQNK ABVGC ABXVV ACAHQ ACFBH ACGFO ACGFS ACMXC ACPOU ACPRK ACSCC ACUFI ACUHS ACVCV ACXQS ADBBV ADEOM ADIPN ADIYS ADIZJ ADKYN ADMGS ADOZA ADQBN ADVEK ADXAS ADZMN AEFGJ AEGXH AEIMD AEMQT AENEX AFBPY AFEBI AFFQV AFFZL AFGKR AFRAH AFTUV AFXAL AFZJQ AGMDO AGORE AGUTN AGXDD AHGBF AHMMS AIACR AIAGR AIDQK AIDYY AIURR AJAOE AJBYB AJDVS AJEEA AJNCP ALAGY ALMA_UNASSIGNED_HOLDINGS ALXQX AMBMR AMYDB AOIJS ATGXG ATUGU AZBYB AZVAB BAFTC BAWUL BCRHZ BEYMZ BHBCM BMXJE BROTX BRXPI BY8 C45 CAG COF D-6 D-7 D-E D-F DCZOG DIK DPXWK DR2 DRFUL DRMAN DRSTM DU5 E3Z EAD EAP EAS EBB EBC EBD EBS EBX EJD EMB EMK EMOBN ESX EX3 F00 F01 F04 F5P FUBAC G-S G.N GODZA GX1 H.X H13 HF~ HZI HZ~ IH2 IHE IX1 J0M J5H K48 KBUDW KBYEO KOP KSI KSN LATKE LC2 LC3 LEEKS LH4 LITHE LOXES LP6 LP7 LUTES LW6 LYRES MK4 MRFUL MRMAN MRSTM MSFUL MSMAN MSSTM MXFUL MXMAN MXSTM N04 N05 N9A NF~ NOMLY NU- O66 O9- OAUYM OBS OCZFY OHT OIG OJZSN OK1 OPAEJ OVD OWPYF P2P P2W P2X P2Z P4B P4D Q.N Q11 QB0 Q~Q R.K ROL ROX RPM RX1 SUPJJ SV3 TEORI TR2 TUS UB1 V8K W8V W99 WBKPD WHWMO WIH WIJ WIK WIN WOHZO WOQ WOW WQJ WVDHM WXI X7M XG1 Y6R YFH YOC YUY ZGI ZXP ZZTAW ~IA ~KM ~WT AAHHS AAYXX ACCFJ ADZOD AEEZP AEQDE AIWBW AJBDE CITATION IQODW 1OC 24P 33P AEUQT AFPWT CGR CUY CVF ECM EIF FIJ IPNFZ NPM WRC 7T5 7U9 H94 M7N 7X8 5PM |
| ID | FETCH-LOGICAL-c5655-a0b4a2029e4daffa0bb07a6aa5719c74baf3887b41484ac8faaa4057d50e10ac3 |
| IEDL.DBID | DR2 |
| ISSN | 0009-9104 1365-2249 |
| IngestDate | Thu Aug 21 13:58:29 EDT 2025 Sun Aug 24 04:07:26 EDT 2025 Fri Jul 11 00:19:00 EDT 2025 Wed Aug 13 09:35:00 EDT 2025 Wed Feb 19 01:51:39 EST 2025 Mon Jul 21 09:14:54 EDT 2025 Tue Jul 01 05:14:25 EDT 2025 Thu Apr 24 22:51:40 EDT 2025 Wed Aug 20 07:25:45 EDT 2025 |
| IsDoiOpenAccess | false |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | Human Calcineurin inhibitor Immune response Enzyme IMP dehydrogenase Enzyme inhibitor Homograft cytotoxic T-lymphocytes islet cell transplantation Lactone Biochemistry Transplantation Macrolide Immunosuppression Treatment Tacrolimus Surgery Graft Protein synthesis inhibitor Oxidoreductases Immunosuppressive agent Mycophenolate mofetil Cell Cytotoxic T lymphocyte |
| Language | English |
| License | https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model CC BY 4.0 2012 The Authors. Clinical and Experimental Immunology © 2012 British Society for Immunology. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c5655-a0b4a2029e4daffa0bb07a6aa5719c74baf3887b41484ac8faaa4057d50e10ac3 |
| Notes | JDRF Center for Beta Cell Therapy in Diabetes. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 |
| OpenAccessLink | https://www.ncbi.nlm.nih.gov/pmc/articles/3406379 |
| PMID | 22774994 |
| PQID | 1545865442 |
| PQPubID | 36527 |
| PageCount | 9 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_3406379 proquest_miscellaneous_1028028346 proquest_miscellaneous_1024476413 proquest_journals_1545865442 pubmed_primary_22774994 pascalfrancis_primary_26116715 crossref_citationtrail_10_1111_j_1365_2249_2012_04605_x crossref_primary_10_1111_j_1365_2249_2012_04605_x wiley_primary_10_1111_j_1365_2249_2012_04605_x_CEI4605 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | August 2012 |
| PublicationDateYYYYMMDD | 2012-08-01 |
| PublicationDate_xml | – month: 08 year: 2012 text: August 2012 |
| PublicationDecade | 2010 |
| PublicationPlace | Oxford, UK |
| PublicationPlace_xml | – name: Oxford, UK – name: Oxford – name: England |
| PublicationTitle | Clinical and experimental immunology |
| PublicationTitleAlternate | Clin Exp Immunol |
| PublicationYear | 2012 |
| Publisher | Blackwell Publishing Ltd Blackwell Oxford University Press Blackwell Science Inc |
| Publisher_xml | – name: Blackwell Publishing Ltd – name: Blackwell – name: Oxford University Press – name: Blackwell Science Inc |
| References | 2009; 88 2010; 59 1995; 59 2000; 23 2006; 55 1991; 52 1999; 48 1999; 291 2006; 15 2000; 20 2004; 4 1998; 338 2009; 156 2010; 185 2006; 6 2005; 43 1994; 46 1992; 35 2010; 161 2008; 3 1992; 53 2006; 355 2006; 212 2009; 58 2007; 178 1993; 56 2004; 53 2004; 351 2009; 50 1999; 18 2009; 9 1988; 23 2008; 118 2005; 54 2010; 252 2007; 7 2008; 22 2000; 343 2005; 56 2006; 103 2009; 18 1996; 45 2011; 186 Strijbosch (2021122708375686800_b23) 1988; 23 Roelen (2021122708375686800_b19) 1992; 53 Ricordi (2021122708375686800_b2) 2004; 4 Halloran (2021122708375686800_b42) 2004; 351 The CITR Research Group (2021122708375686800_b29) 2009; 18 Waldmann (2021122708375686800_b48) 2006; 212 Decochez (2021122708375686800_b21) 2000; 23 Nagase (2021122708375686800_b39) 1994; 46 Orlando (2021122708375686800_b14) 2009; 50 Huurman (2021122708375686800_b16) 2008; 3 Johnson (2021122708375686800_b12) 2009; 18 Roncarolo (2021122708375686800_b9) 2006; 212 Penn (2021122708375686800_b6) 1995; 59 Merkel (2021122708375686800_b27) 2005; 43 Meiser (2021122708375686800_b40) 1999; 18 Roelen (2021122708375686800_b18) 2009; 156 Salama (2021122708375686800_b46) 2007; 178 Keymeulen (2021122708375686800_b30) 1996; 45 Gorantla (2021122708375686800_b41) 2000; 20 Rickels (2021122708375686800_b35) 2006; 15 Velthuis (2021122708375686800_b47) 2010; 59 Shapiro (2021122708375686800_b3) 2006; 355 Levitsky (2021122708375686800_b49) 2009; 88 Orlando (2021122708375686800_b15) 2010; 252 Keymeulen (2021122708375686800_b4) 2006; 103 Housley (2021122708375686800_b44) 2011; 186 Tree (2021122708375686800_b50) 2010; 59 Ouwehand (2021122708375686800_b33) 1993; 56 Ricordi (2021122708375686800_b10) 1991; 52 Skowera (2021122708375686800_b32) 2008; 118 Campbell (2021122708375686800_b36) 2007; 7 Huurman (2021122708375686800_b17) 2009; 9 Sewgobind (2021122708375686800_b45) 2010; 161 Fishman (2021122708375686800_b7) 1998; 338 Taylor (2021122708375686800_b8) 2005; 56 van Besouw (2021122708375686800_b31) 2008; 22 Roelen (2021122708375686800_b24) 1993; 56 Vendrame (2021122708375686800_b37) 2010; 59 Hilbrands (2021122708375686800_b38) 2009; 58 Kleijwegt (2021122708375686800_b43) 2010; 185 Roep (2021122708375686800_b20) 1999; 48 Zhang (2021122708375686800_b11) 2006; 55 Ryan (2021122708375686800_b5) 2005; 54 Gummert (2021122708375686800_b25) 1999; 291 Monti (2021122708375686800_b26) 2008; 118 Street (2021122708375686800_b28) 2004; 53 Roelen (2021122708375686800_b34) 1995; 59 Shapiro (2021122708375686800_b1) 2000; 343 Roussey-Kesler (2021122708375686800_b13) 2006; 6 Bouma (2021122708375686800_b22) 1992; 35 18365398 - Clin Transpl. 2006;:413-20 19996930 - Transplantation. 2009 Dec 15;88(11):1303-11 16903922 - Immunol Rev. 2006 Aug;212:301-13 15983207 - Diabetes. 2005 Jul;54(7):2060-9 10565830 - J Pharmacol Exp Ther. 1999 Dec;291(3):1100-12 17442921 - J Immunol. 2007 May 1;178(9):5419-23 15057784 - Nat Rev Immunol. 2004 Apr;4(4):259-68 7709440 - Transplantation. 1995 Apr 15;59(7):1039-42 1566356 - Transplantation. 1992 Apr;53(4):899-903 19067657 - Am J Transplant. 2009 Feb;9(2):382-8 9624195 - N Engl J Med. 1998 Jun 11;338(24):1741-51 17005949 - N Engl J Med. 2006 Sep 28;355(13):1318-30 3225063 - Int J Biomed Comput. 1988 Dec;23(3-4):279-90 1716797 - Transplantation. 1991 Sep;52(3):519-22 16119513 - Int J Clin Pharmacol Ther. 2005 Aug;43(8):379-88 20357361 - Diabetes. 2010 Jul;59(7):1721-30 17090674 - Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17444-9 19500470 - Cell Transplant. 2009;18(8):833-45 15561940 - Diabetes. 2004 Dec;53(12):3107-14 16936190 - Diabetes. 2006 Sep;55(9):2429-36 1286979 - Hum Immunol. 1992 Oct;35(2):85-92 11150994 - Microsurgery. 2000;20(8):420-9 16539630 - Am J Transplant. 2006 Apr;6(4):736-46 19602536 - Diabetes. 2009 Oct;58(10):2267-76 18802479 - J Clin Invest. 2008 Oct;118(10):3390-402 19796497 - Cell Transplant. 2009;18(7):753-67 20299476 - Diabetes. 2010 Jun;59(6):1451-60 8922370 - Diabetes. 1996 Dec;45(12):1814-21 10911004 - N Engl J Med. 2000 Jul 27;343(4):230-8 10194038 - J Heart Lung Transplant. 1999 Feb;18(2):143-9 7687397 - Transplantation. 1993 Jul;56(1):190-5 21107102 - Ann Surg. 2010 Dec;252(6):915-28 20528886 - Clin Exp Immunol. 2010 Aug;161(2):364-77 8249126 - Transplantation. 1993 Nov;56(5):1223-9 16903904 - Immunol Rev. 2006 Aug;212:28-50 19394103 - J Hepatol. 2009 Jun;50(6):1247-57 7517447 - J Pharm Pharmacol. 1994 Feb;46(2):113-7 18431516 - J Clin Invest. 2008 May;118(5):1806-14 20574005 - J Immunol. 2010 Aug 1;185(3):1412-8 20086230 - Diabetes. 2010 Apr;59(4):947-57 10078547 - Diabetes. 1999 Mar;48(3):484-90 7878750 - Transplantation. 1995 Feb 27;59(4):480-5 10841006 - Diabetes Care. 2000 Jun;23(6):838-44 17845564 - Am J Transplant. 2007 Oct;7(10):2311-7 19161445 - Clin Exp Immunol. 2009 Apr;156(1):141-8 15616206 - N Engl J Med. 2004 Dec 23;351(26):2715-29 21572024 - J Immunol. 2011 Jun 15;186(12):6779-87 18339130 - Clin Transplant. 2008 Mar-Apr;22(2):129-35 18560516 - PLoS One. 2008;3(6):e2435 15979320 - Crit Rev Oncol Hematol. 2005 Oct;56(1):155-67 |
| References_xml | – volume: 4 start-page: 259 year: 2004 end-page: 68 article-title: Clinical islet transplantation: advances and immunological challenges publication-title: Nat Rev Immunol – volume: 43 start-page: 379 year: 2005 end-page: 88 article-title: Trough levels of mycophenolic acid and its glucuronidated metabolite in renal transplant recipients publication-title: Int J Clin Pharmacol Ther – volume: 56 start-page: 190 year: 1993 end-page: 5 article-title: Differential inhibition of primed alloreactive CTLs in vitro by clinically used concentrations of cyclosporine and FK506 publication-title: Transplantation – volume: 18 start-page: 833 year: 2009 end-page: 45 article-title: Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose‐stimulated insulin release and apoptosis in human islets publication-title: Cell Transplant – volume: 59 start-page: 1721 year: 2010 end-page: 30 article-title: Simultaneous detection of circulating autoreactive CD8+ T‐cells specific for different islet cell‐associated epitopes using combinatorial MHC multimers publication-title: Diabetes – volume: 55 start-page: 2429 year: 2006 end-page: 36 article-title: Sirolimus is associated with reduced islet engraftment and impaired beta‐cell function publication-title: Diabetes – volume: 6 start-page: 736 year: 2006 end-page: 46 article-title: Clinical operational tolerance after kidney transplantation publication-title: Am J Transplant – volume: 103 start-page: 17444 year: 2006 end-page: 9 article-title: Correlation between beta cell mass and glycemic control in type 1 diabetic recipients of islet cell graft publication-title: Proc Natl Acad Sci U S A – volume: 48 start-page: 484 year: 1999 end-page: 90 article-title: Auto‐ and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients publication-title: Diabetes – volume: 59 start-page: 480 year: 1995 end-page: 5 article-title: Primary kidney tumors before and after renal transplantation publication-title: Transplantation – volume: 23 start-page: 279 year: 1988 end-page: 90 article-title: Computer aided design and evaluation of limiting and serial dilution experiments publication-title: Int J Biomed Comput – volume: 18 start-page: 753 year: 2009 end-page: 67 article-title: 2007 update on allogeneic islet transplantation from the Collaborative Islet Transplant Registry (CITR) publication-title: Cell Transplant – volume: 50 start-page: 1247 year: 2009 end-page: 57 article-title: Operational tolerance after liver transplantation publication-title: J Hepatol – volume: 59 start-page: 947 year: 2010 end-page: 57 article-title: Recurrence of type 1 diabetes after simultaneous pancreas‐kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T‐cells publication-title: Diabetes – volume: 161 start-page: 364 year: 2010 end-page: 77 article-title: The calcineurin inhibitor tacrolimus allows the induction of functional CD4CD25 regulatory T cells by rabbit anti‐thymocyte globulins publication-title: Clin Exp Immunol – volume: 355 start-page: 1318 year: 2006 end-page: 30 article-title: International trial of the Edmonton protocol for islet transplantation publication-title: N Engl J Med – volume: 56 start-page: 155 year: 2005 end-page: 67 article-title: Post‐transplant lymphoproliferative disorders (PTLD) after solid organ transplantation publication-title: Crit Rev Oncol Hematol – volume: 212 start-page: 28 year: 2006 end-page: 50 article-title: Interleukin‐10‐secreting type 1 regulatory T cells in rodents and humans publication-title: Immunol Rev – volume: 23 start-page: 838 year: 2000 end-page: 44 article-title: High frequency of persisting or increasing islet‐specific autoantibody levels after diagnosis of type 1 diabetes presenting before 40 years of age. The Belgian Diabetes Registry publication-title: Diabetes Care – volume: 186 start-page: 6779 year: 2011 end-page: 87 article-title: Natural but not inducible regulatory T cells require TNF‐{alpha} signaling for in vivo function publication-title: J Immunol – volume: 54 start-page: 2060 year: 2005 end-page: 9 article-title: Five‐year follow‐up after clinical islet transplantation publication-title: Diabetes – volume: 53 start-page: 899 year: 1992 end-page: 903 article-title: Evidence that antibody formation against a certain HLA alloantigen is associated not with a quantitative but with a qualitative change in the cytotoxic T cells recognizing the same antigen publication-title: Transplantation – volume: 7 start-page: 2311 year: 2007 end-page: 17 article-title: High risk of sensitization after failed islet transplantation publication-title: Am J Transplant – volume: 22 start-page: 129 year: 2008 end-page: 35 article-title: After discontinuation of calcineurin inhibitors, tapering of mycophenolate mofetil further impairs donor‐directed cytotoxicity publication-title: Clin Transplant – volume: 35 start-page: 85 year: 1992 end-page: 92 article-title: Determination of cytotoxic T‐lymphocyte precursor frequencies using europium labeling as a nonradioactive alternative to labeling with chromium‐51 publication-title: Hum Immunol – volume: 52 start-page: 519 year: 1991 end-page: 22 article-title: In vivo effect of FK506 on human pancreatic islets publication-title: Transplantation – volume: 59 start-page: 1451 year: 2010 end-page: 60 article-title: Naturally arising human CD4 T‐cells that recognize islet autoantigens and secrete interleukin‐10 regulate proinflammatory T‐cell responses via linked suppression publication-title: Diabetes – volume: 291 start-page: 1100 year: 1999 end-page: 12 article-title: Pharmacodynamics of immunosuppression by mycophenolic acid: inhibition of both lymphocyte proliferation and activation correlates with pharmacokinetics publication-title: J Pharmacol Exp Ther – volume: 20 start-page: 420 year: 2000 end-page: 9 article-title: Immunosuppressive agents in transplantation: mechanisms of action and current anti‐rejection strategies publication-title: Microsurgery – volume: 46 start-page: 113 year: 1994 end-page: 17 article-title: Distribution and protein binding of FK506, a potent immunosuppressive macrolide lactone, in human blood and its uptake by erythrocytes publication-title: J Pharm Pharmacol – volume: 3 start-page: e2435 year: 2008 article-title: Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation publication-title: PLoS ONE – volume: 118 start-page: 1806 year: 2008 end-page: 14 article-title: Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells publication-title: J Clin Invest – volume: 18 start-page: 143 year: 1999 end-page: 9 article-title: Combination therapy with tacrolimus and mycophenolate mofetil following cardiac transplantation: importance of mycophenolic acid therapeutic drug monitoring publication-title: J Heart Lung Transplant – volume: 56 start-page: 1223 year: 1993 end-page: 9 article-title: The detection of cytotoxic T cells with high‐affinity receptors for donor antigens in the transplanted heart as a prognostic factor for graft rejection publication-title: Transplantation – volume: 212 start-page: 301 year: 2006 end-page: 13 article-title: Infectious tolerance and the long‐term acceptance of transplanted tissue publication-title: Immunol Rev – volume: 185 start-page: 1412 year: 2010 end-page: 18 article-title: Critical role for TNF in the induction of human antigen‐specific regulatory T cells by tolerogenic dendritic cells publication-title: J Immunol – volume: 59 start-page: 1039 year: 1995 end-page: 42 article-title: The presence of activated donor HLA class I‐reactive T lymphocytes is associated with rejection of corneal grafts publication-title: Transplantation – volume: 178 start-page: 5419 year: 2007 end-page: 23 article-title: Clinical transplantation tolerance: many rivers to cross publication-title: J Immunol – volume: 15 start-page: 413 year: 2006 end-page: 20 article-title: HLA sensitization in islet transplantation publication-title: Clin Transpl – volume: 53 start-page: 3107 year: 2004 end-page: 14 article-title: Islet graft assessment in the Edmonton Protocol: implications for predicting long‐term clinical outcome publication-title: Diabetes – volume: 252 start-page: 915 year: 2010 end-page: 28 article-title: Clinical operational tolerance after renal transplantation: current status and future challenges publication-title: Ann Surg – volume: 338 start-page: 1741 year: 1998 end-page: 51 article-title: Infection in organ‐transplant recipients publication-title: N Engl J Med – volume: 156 start-page: 141 year: 2009 end-page: 8 article-title: Relevance of cytotoxic alloreactivity under different immunosuppressive regimens in clinical islet cell transplantation publication-title: Clin Exp Immunol – volume: 45 start-page: 1814 year: 1996 end-page: 21 article-title: Long‐term metabolic control by rat islet grafts depends on the composition of the implant publication-title: Diabetes – volume: 58 start-page: 2267 year: 2009 end-page: 76 article-title: Differences in baseline lymphocyte counts and autoreactivity are associated with differences in outcome of islet cell transplantation in type 1 diabetic patients publication-title: Diabetes – volume: 351 start-page: 2715 year: 2004 end-page: 29 article-title: Immunosuppressive drugs for kidney transplantation publication-title: N Engl J Med – volume: 9 start-page: 382 year: 2009 end-page: 8 article-title: Allograft‐specific cytokine profiles associate with clinical outcome after islet cell transplantation publication-title: Am J Transplant – volume: 88 start-page: 1303 year: 2009 end-page: 11 article-title: The human ‘Treg MLR’: immune monitoring for FOXP3+ T regulatory cell generation publication-title: Transplantation – volume: 118 start-page: 3390 year: 2008 end-page: 402 article-title: CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose‐regulated preproinsulin epitope publication-title: J Clin Invest – volume: 343 start-page: 230 year: 2000 end-page: 8 article-title: Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid‐free immunosuppressive regimen publication-title: N Engl J Med – volume: 338 start-page: 1741 year: 1998 ident: 2021122708375686800_b7 article-title: Infection in organ-transplant recipients publication-title: N Engl J Med doi: 10.1056/NEJM199806113382407 – volume: 4 start-page: 259 year: 2004 ident: 2021122708375686800_b2 article-title: Clinical islet transplantation: advances and immunological challenges publication-title: Nat Rev Immunol doi: 10.1038/nri1332 – volume: 59 start-page: 1721 year: 2010 ident: 2021122708375686800_b47 article-title: Simultaneous detection of circulating autoreactive CD8+ T-cells specific for different islet cell-associated epitopes using combinatorial MHC multimers publication-title: Diabetes doi: 10.2337/db09-1486 – volume: 52 start-page: 519 year: 1991 ident: 2021122708375686800_b10 article-title: In vivo effect of FK506 on human pancreatic islets publication-title: Transplantation doi: 10.1097/00007890-199109000-00026 – volume: 48 start-page: 484 year: 1999 ident: 2021122708375686800_b20 article-title: Auto- and alloimmune reactivity to human islet allografts transplanted into type 1 diabetic patients publication-title: Diabetes doi: 10.2337/diabetes.48.3.484 – volume: 88 start-page: 1303 year: 2009 ident: 2021122708375686800_b49 article-title: The human ‘Treg MLR’: immune monitoring for FOXP3+ T regulatory cell generation publication-title: Transplantation doi: 10.1097/TP.0b013e3181bbee98 – volume: 46 start-page: 113 year: 1994 ident: 2021122708375686800_b39 article-title: Distribution and protein binding of FK506, a potent immunosuppressive macrolide lactone, in human blood and its uptake by erythrocytes publication-title: J Pharm Pharmacol doi: 10.1111/j.2042-7158.1994.tb03752.x – volume: 161 start-page: 364 year: 2010 ident: 2021122708375686800_b45 article-title: The calcineurin inhibitor tacrolimus allows the induction of functional CD4CD25 regulatory T cells by rabbit anti-thymocyte globulins publication-title: Clin Exp Immunol doi: 10.1111/j.1365-2249.2010.04183.x – volume: 56 start-page: 155 year: 2005 ident: 2021122708375686800_b8 article-title: Post-transplant lymphoproliferative disorders (PTLD) after solid organ transplantation publication-title: Crit Rev Oncol Hematol doi: 10.1016/j.critrevonc.2005.03.015 – volume: 355 start-page: 1318 year: 2006 ident: 2021122708375686800_b3 article-title: International trial of the Edmonton protocol for islet transplantation publication-title: N Engl J Med doi: 10.1056/NEJMoa061267 – volume: 103 start-page: 17444 year: 2006 ident: 2021122708375686800_b4 article-title: Correlation between beta cell mass and glycemic control in type 1 diabetic recipients of islet cell graft publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.0608141103 – volume: 23 start-page: 838 year: 2000 ident: 2021122708375686800_b21 article-title: High frequency of persisting or increasing islet-specific autoantibody levels after diagnosis of type 1 diabetes presenting before 40 years of age. The Belgian Diabetes Registry publication-title: Diabetes Care doi: 10.2337/diacare.23.6.838 – volume: 186 start-page: 6779 year: 2011 ident: 2021122708375686800_b44 article-title: Natural but not inducible regulatory T cells require TNF-{alpha} signaling for in vivo function publication-title: J Immunol doi: 10.4049/jimmunol.1003868 – volume: 54 start-page: 2060 year: 2005 ident: 2021122708375686800_b5 article-title: Five-year follow-up after clinical islet transplantation publication-title: Diabetes doi: 10.2337/diabetes.54.7.2060 – volume: 59 start-page: 1451 year: 2010 ident: 2021122708375686800_b50 article-title: Naturally arising human CD4 T-cells that recognize islet autoantigens and secrete interleukin-10 regulate proinflammatory T-cell responses via linked suppression publication-title: Diabetes doi: 10.2337/db09-0503 – volume: 212 start-page: 301 year: 2006 ident: 2021122708375686800_b48 article-title: Infectious tolerance and the long-term acceptance of transplanted tissue publication-title: Immunol Rev doi: 10.1111/j.0105-2896.2006.00406.x – volume: 23 start-page: 279 year: 1988 ident: 2021122708375686800_b23 article-title: Computer aided design and evaluation of limiting and serial dilution experiments publication-title: Int J Biomed Comput doi: 10.1016/0020-7101(88)90020-7 – volume: 43 start-page: 379 year: 2005 ident: 2021122708375686800_b27 article-title: Trough levels of mycophenolic acid and its glucuronidated metabolite in renal transplant recipients publication-title: Int J Clin Pharmacol Ther doi: 10.5414/CPP43379 – volume: 18 start-page: 753 year: 2009 ident: 2021122708375686800_b29 article-title: 2007 update on allogeneic islet transplantation from the Collaborative Islet Transplant Registry (CITR) publication-title: Cell Transplant doi: 10.3727/096368909X470874 – volume: 156 start-page: 141 year: 2009 ident: 2021122708375686800_b18 article-title: Relevance of cytotoxic alloreactivity under different immunosuppressive regimens in clinical islet cell transplantation publication-title: Clin Exp Immunol doi: 10.1111/j.1365-2249.2008.03812.x – volume: 45 start-page: 1814 year: 1996 ident: 2021122708375686800_b30 article-title: Long-term metabolic control by rat islet grafts depends on the composition of the implant publication-title: Diabetes doi: 10.2337/diab.45.12.1814 – volume: 53 start-page: 899 year: 1992 ident: 2021122708375686800_b19 article-title: Evidence that antibody formation against a certain HLA alloantigen is associated not with a quantitative but with a qualitative change in the cytotoxic T cells recognizing the same antigen publication-title: Transplantation doi: 10.1097/00007890-199204000-00035 – volume: 118 start-page: 1806 year: 2008 ident: 2021122708375686800_b26 article-title: Islet transplantation in patients with autoimmune diabetes induces homeostatic cytokines that expand autoreactive memory T cells publication-title: J Clin Invest – volume: 7 start-page: 2311 year: 2007 ident: 2021122708375686800_b36 article-title: High risk of sensitization after failed islet transplantation publication-title: Am J Transplant doi: 10.1111/j.1600-6143.2007.01923.x – volume: 178 start-page: 5419 year: 2007 ident: 2021122708375686800_b46 article-title: Clinical transplantation tolerance: many rivers to cross publication-title: J Immunol doi: 10.4049/jimmunol.178.9.5419 – volume: 15 start-page: 413 year: 2006 ident: 2021122708375686800_b35 article-title: HLA sensitization in islet transplantation publication-title: Clin Transpl – volume: 20 start-page: 420 year: 2000 ident: 2021122708375686800_b41 article-title: Immunosuppressive agents in transplantation: mechanisms of action and current anti-rejection strategies publication-title: Microsurgery doi: 10.1002/1098-2752(2000)20:8<420::AID-MICR13>3.0.CO;2-O – volume: 55 start-page: 2429 year: 2006 ident: 2021122708375686800_b11 article-title: Sirolimus is associated with reduced islet engraftment and impaired beta-cell function publication-title: Diabetes doi: 10.2337/db06-0173 – volume: 351 start-page: 2715 year: 2004 ident: 2021122708375686800_b42 article-title: Immunosuppressive drugs for kidney transplantation publication-title: N Engl J Med doi: 10.1056/NEJMra033540 – volume: 58 start-page: 2267 year: 2009 ident: 2021122708375686800_b38 article-title: Differences in baseline lymphocyte counts and autoreactivity are associated with differences in outcome of islet cell transplantation in type 1 diabetic patients publication-title: Diabetes doi: 10.2337/db09-0160 – volume: 118 start-page: 3390 year: 2008 ident: 2021122708375686800_b32 article-title: CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope publication-title: J Clin Invest – volume: 212 start-page: 28 year: 2006 ident: 2021122708375686800_b9 article-title: Interleukin-10-secreting type 1 regulatory T cells in rodents and humans publication-title: Immunol Rev doi: 10.1111/j.0105-2896.2006.00420.x – volume: 252 start-page: 915 year: 2010 ident: 2021122708375686800_b15 article-title: Clinical operational tolerance after renal transplantation: current status and future challenges publication-title: Ann Surg doi: 10.1097/SLA.0b013e3181f3efb0 – volume: 3 start-page: e2435 year: 2008 ident: 2021122708375686800_b16 article-title: Cellular islet autoimmunity associates with clinical outcome of islet cell transplantation publication-title: PLoS ONE doi: 10.1371/journal.pone.0002435 – volume: 9 start-page: 382 year: 2009 ident: 2021122708375686800_b17 article-title: Allograft-specific cytokine profiles associate with clinical outcome after islet cell transplantation publication-title: Am J Transplant doi: 10.1111/j.1600-6143.2008.02479.x – volume: 291 start-page: 1100 year: 1999 ident: 2021122708375686800_b25 article-title: Pharmacodynamics of immunosuppression by mycophenolic acid: inhibition of both lymphocyte proliferation and activation correlates with pharmacokinetics publication-title: J Pharmacol Exp Ther doi: 10.1016/S0022-3565(24)35215-2 – volume: 59 start-page: 1039 year: 1995 ident: 2021122708375686800_b34 article-title: The presence of activated donor HLA class I-reactive T lymphocytes is associated with rejection of corneal grafts publication-title: Transplantation doi: 10.1097/00007890-199504150-00021 – volume: 50 start-page: 1247 year: 2009 ident: 2021122708375686800_b14 article-title: Operational tolerance after liver transplantation publication-title: J Hepatol doi: 10.1016/j.jhep.2009.03.006 – volume: 18 start-page: 143 year: 1999 ident: 2021122708375686800_b40 article-title: Combination therapy with tacrolimus and mycophenolate mofetil following cardiac transplantation: importance of mycophenolic acid therapeutic drug monitoring publication-title: J Heart Lung Transplant doi: 10.1016/S1053-2498(98)00002-3 – volume: 6 start-page: 736 year: 2006 ident: 2021122708375686800_b13 article-title: Clinical operational tolerance after kidney transplantation publication-title: Am J Transplant doi: 10.1111/j.1600-6143.2006.01280.x – volume: 18 start-page: 833 year: 2009 ident: 2021122708375686800_b12 article-title: Different effects of FK506, rapamycin, and mycophenolate mofetil on glucose-stimulated insulin release and apoptosis in human islets publication-title: Cell Transplant doi: 10.3727/096368909X471198 – volume: 56 start-page: 1223 year: 1993 ident: 2021122708375686800_b33 article-title: The detection of cytotoxic T cells with high-affinity receptors for donor antigens in the transplanted heart as a prognostic factor for graft rejection publication-title: Transplantation doi: 10.1097/00007890-199311000-00033 – volume: 22 start-page: 129 year: 2008 ident: 2021122708375686800_b31 article-title: After discontinuation of calcineurin inhibitors, tapering of mycophenolate mofetil further impairs donor-directed cytotoxicity publication-title: Clin Transplant doi: 10.1111/j.1399-0012.2007.00754.x – volume: 56 start-page: 190 year: 1993 ident: 2021122708375686800_b24 article-title: Differential inhibition of primed alloreactive CTLs in vitro by clinically used concentrations of cyclosporine and FK506 publication-title: Transplantation doi: 10.1097/00007890-199307000-00035 – volume: 35 start-page: 85 year: 1992 ident: 2021122708375686800_b22 article-title: Determination of cytotoxic T-lymphocyte precursor frequencies using europium labeling as a nonradioactive alternative to labeling with chromium-51 publication-title: Hum Immunol doi: 10.1016/0198-8859(92)90015-F – volume: 59 start-page: 947 year: 2010 ident: 2021122708375686800_b37 article-title: Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells publication-title: Diabetes doi: 10.2337/db09-0498 – volume: 53 start-page: 3107 year: 2004 ident: 2021122708375686800_b28 article-title: Islet graft assessment in the Edmonton Protocol: implications for predicting long-term clinical outcome publication-title: Diabetes doi: 10.2337/diabetes.53.12.3107 – volume: 185 start-page: 1412 year: 2010 ident: 2021122708375686800_b43 article-title: Critical role for TNF in the induction of human antigen-specific regulatory T cells by tolerogenic dendritic cells publication-title: J Immunol doi: 10.4049/jimmunol.1000560 – volume: 343 start-page: 230 year: 2000 ident: 2021122708375686800_b1 article-title: Islet transplantation in seven patients with type 1 diabetes mellitus using a glucocorticoid-free immunosuppressive regimen publication-title: N Engl J Med doi: 10.1056/NEJM200007273430401 – volume: 59 start-page: 480 year: 1995 ident: 2021122708375686800_b6 article-title: Primary kidney tumors before and after renal transplantation publication-title: Transplantation doi: 10.1097/00007890-199559040-00006 – reference: 18802479 - J Clin Invest. 2008 Oct;118(10):3390-402 – reference: 16539630 - Am J Transplant. 2006 Apr;6(4):736-46 – reference: 15561940 - Diabetes. 2004 Dec;53(12):3107-14 – reference: 18431516 - J Clin Invest. 2008 May;118(5):1806-14 – reference: 19796497 - Cell Transplant. 2009;18(7):753-67 – reference: 16119513 - Int J Clin Pharmacol Ther. 2005 Aug;43(8):379-88 – reference: 20086230 - Diabetes. 2010 Apr;59(4):947-57 – reference: 20528886 - Clin Exp Immunol. 2010 Aug;161(2):364-77 – reference: 16903904 - Immunol Rev. 2006 Aug;212:28-50 – reference: 16936190 - Diabetes. 2006 Sep;55(9):2429-36 – reference: 20299476 - Diabetes. 2010 Jun;59(6):1451-60 – reference: 10841006 - Diabetes Care. 2000 Jun;23(6):838-44 – reference: 19394103 - J Hepatol. 2009 Jun;50(6):1247-57 – reference: 19067657 - Am J Transplant. 2009 Feb;9(2):382-8 – reference: 7517447 - J Pharm Pharmacol. 1994 Feb;46(2):113-7 – reference: 17442921 - J Immunol. 2007 May 1;178(9):5419-23 – reference: 7878750 - Transplantation. 1995 Feb 27;59(4):480-5 – reference: 10565830 - J Pharmacol Exp Ther. 1999 Dec;291(3):1100-12 – reference: 21572024 - J Immunol. 2011 Jun 15;186(12):6779-87 – reference: 8249126 - Transplantation. 1993 Nov;56(5):1223-9 – reference: 10194038 - J Heart Lung Transplant. 1999 Feb;18(2):143-9 – reference: 19602536 - Diabetes. 2009 Oct;58(10):2267-76 – reference: 1286979 - Hum Immunol. 1992 Oct;35(2):85-92 – reference: 21107102 - Ann Surg. 2010 Dec;252(6):915-28 – reference: 7709440 - Transplantation. 1995 Apr 15;59(7):1039-42 – reference: 15057784 - Nat Rev Immunol. 2004 Apr;4(4):259-68 – reference: 10911004 - N Engl J Med. 2000 Jul 27;343(4):230-8 – reference: 15616206 - N Engl J Med. 2004 Dec 23;351(26):2715-29 – reference: 9624195 - N Engl J Med. 1998 Jun 11;338(24):1741-51 – reference: 1566356 - Transplantation. 1992 Apr;53(4):899-903 – reference: 20357361 - Diabetes. 2010 Jul;59(7):1721-30 – reference: 17090674 - Proc Natl Acad Sci U S A. 2006 Nov 14;103(46):17444-9 – reference: 18339130 - Clin Transplant. 2008 Mar-Apr;22(2):129-35 – reference: 15979320 - Crit Rev Oncol Hematol. 2005 Oct;56(1):155-67 – reference: 18365398 - Clin Transpl. 2006;:413-20 – reference: 19161445 - Clin Exp Immunol. 2009 Apr;156(1):141-8 – reference: 19996930 - Transplantation. 2009 Dec 15;88(11):1303-11 – reference: 10078547 - Diabetes. 1999 Mar;48(3):484-90 – reference: 19500470 - Cell Transplant. 2009;18(8):833-45 – reference: 11150994 - Microsurgery. 2000;20(8):420-9 – reference: 7687397 - Transplantation. 1993 Jul;56(1):190-5 – reference: 15983207 - Diabetes. 2005 Jul;54(7):2060-9 – reference: 1716797 - Transplantation. 1991 Sep;52(3):519-22 – reference: 3225063 - Int J Biomed Comput. 1988 Dec;23(3-4):279-90 – reference: 8922370 - Diabetes. 1996 Dec;45(12):1814-21 – reference: 18560516 - PLoS One. 2008;3(6):e2435 – reference: 17845564 - Am J Transplant. 2007 Oct;7(10):2311-7 – reference: 16903922 - Immunol Rev. 2006 Aug;212:301-13 – reference: 20574005 - J Immunol. 2010 Aug 1;185(3):1412-8 – reference: 17005949 - N Engl J Med. 2006 Sep 28;355(13):1318-30 |
| SSID | ssj0006662 |
| Score | 2.1358576 |
| Snippet | Summary
Transplantation of isolated islet of Langerhans cells has great potential as a cure for type 1 diabetes but continuous immune suppressive therapy often... Transplantation of isolated islet of Langerhans cells has great potential as a cure for type 1 diabetes but continuous immune suppressive therapy often causes... Summary Transplantation of isolated islet of Langerhans cells has great potential as a cure for type 1 diabetes but continuous immune suppressive therapy often... |
| SourceID | pubmedcentral proquest pubmed pascalfrancis crossref wiley |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 190 |
| SubjectTerms | Adult Analytical, structural and metabolic biochemistry Autoimmunity Avidity Biological and medical sciences biomarkers CD8 antigen Cytokines Cytokines - biosynthesis cytotoxic T‐lymphocytes Cytotoxicity Diabetes mellitus Donors Female Follow-Up Studies Fundamental and applied biological sciences. Psychology Graft rejection Graft Survival - drug effects Graft Survival - immunology Humans Immune response Immunity Immunity, Cellular Immunosuppression Immunosuppressive Agents - administration & dosage Inflammation islet cell transplantation Islet cells Islets of Langerhans Islets of Langerhans - immunology Islets of Langerhans Transplantation - immunology Lymphocytes T Male Metabolites Middle Aged Mycophenolate mofetil Original Pancreatic islet transplantation Pilot Projects Risk factors Side effects T-Lymphocytes, Cytotoxic - immunology Tacrolimus Transplantation Transplantation, Homologous |
| Title | Immune responses against islet allografts during tapering of immunosuppression – a pilot study in 5 subjects |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1365-2249.2012.04605.x https://www.ncbi.nlm.nih.gov/pubmed/22774994 https://www.proquest.com/docview/1545865442 https://www.proquest.com/docview/1024476413 https://www.proquest.com/docview/1028028346 https://pubmed.ncbi.nlm.nih.gov/PMC3406379 |
| Volume | 169 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1fa9RAEF-koAjin6o1WssKvubIJrvJ5VFKayvog1i4tzCb7NbQkoRLAq1Pfge_oZ_EmU0ubbRIEV-Ou9udkJub2f1N5rczjL0VygbaAuUHZeLLHJQPaZT7RS6KIhIQCOOqfX6Kj07kh5VajfwnOgsz1IeYHriRZ7j1mhwcdDt3csfQwviBGFrhwqX4FoQnaYDw0eerSlKI0sNNUzXcIeWc1HPjhWY71YMGWlSaHbpd3ARH_2RVXke7brs6fMTONj90YKmcLfpOL_Jvv9WA_D-aeMwejqiWvxvM8Am7Y6ptdnfoc3m5ze59HDP4T1l1TAdSDF8P3FzTcjiFEjEqL1s0IU48gNM12K7lwwlK3kHjyiXy2vKShOu2b0b6bsV_fv_BgTfled1xVyqXlxVXvO01PWBqn7GTw4Mv-0f-2PPBzxFaoqEEWkIYhKmRBViLH3WQQAygEpHmidRgI1wXtcQwTkK-tABAmLNQgREB5NFztlXVlXnBeCwgLRSlmayQ1oQQ2KWJY6tAS9ySU48lm_83y8eC6NSX4zy7FhihYjNSbEaKzZxiswuPiUmyGYqC3EJmb2ZCkyCGsHiPQnlsd2NT2biOtJnLa8ZKytBjb6ZhXAEorQOVqXucg24mkxjRyF_nLAlJythjO4OZXt1AiCFAmkrUx8yApwlUgXw-UpVfXSXyCOFglKAmY2eft1ZGtn9wTO9e_qvgK3afvh6YmLtsq1v35jWiw07vOb_H1_cr8QuSIVkA |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9QwELZQEQ8J8SivQClG4ppVHnayOaKq1S60PaBW6i2aJHaJWCXRJpGAE_-Bf8gvYcbOpg1UqELcsoonSmbH4288428Ye-tL7WUaKD8oYlfkIF1Iwtwtcr8oQh88Xxm2z-NocSren8mzoR0QnYWx_BDjhhvNDOOvaYLThvR0lpsSLQwgqEQrmJkc3wwB5U1q8G3iq48XXFKI04NNWzVcI8W0rOfKJ03WqnsNtKg2bftdXAVI_6yrvIx3zYJ18ICtNp9q61Q-z_oum-XffmOB_E-6eMjuD8CWv7OW-IjdUNU2u2VbXX7dZrePhiT-Y1Yt6UyK4mtbnqtaDudQIkzlZYtWxKkU4HwNumu5PUTJO2gMYyKvNS9JuG77ZqjgrfjP7z848KZc1R03bLm8rLjkbZ_RHlP7hJ0e7J_sLdyh7YObI7pEW_EyAYEXJEoUoDX-zLwYIgAZ-0keiwx0iK4xExjJCcjnGgAIdhbSU74HefiUbVV1pZ4zHvmQFJIyTdoXWgXg6bmKIi0hE7gqJw6LN39wmg-c6NSaY5Veio1QsSkpNiXFpkax6ReH-aNkY3lBriGzO7GhURCjWHxHXzpsZ2NU6eBK2tSkNiMpROCwN-NtdAKU2YFK1T2OwZkm4ggByV_HzAlMishhz6ydXrxAgFFAkgjUx8SCxwFEQj69U5WfDBl5iIgwjFGTkTHQaysj3dtf0tWLfxV8ze4sTo4O08Pl8YeX7C4NsYWZO2yrW_fqFYLFLts1TuAX3yZcKg |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3bbtQwELVQERUS4lJugVKMxGtWcWInm0fUdtXlUiFEpb5Zk8Ruo1ZJtEkk4Il_4A_5EsZ2Nm2gQhXiLat4VtnZsX0mc3yGkNdM6CDTYOqDPPF5DsKHNMr9ImdFETEImLJqn4fxwRF_eyyOB_6TOQvj9CHGF25mZtj12kzwptDTSW4ZWpg_GIZWOLMlvhniyZt4MTcRvvfpQkoKYXq47qqGWySfsnqu_KbJVnWngRa9pl27i6vw6J-0ystw1-5Xi3vkbP1LHU3lbNZ32Sz_9psI5P9xxX1yd4C19I2Lwwfkhqq2yC3X6PLrFtn8MJTwH5JqaU6kKLpy5FzVUjiBEkEqLVuMIWqIACcr0F1L3RFK2kFj9RJprWlpjOu2bwb-bkV_fv9BgTbled1Rq5VLy4oK2vaZecPUPiJHi_3Puwf-0PTBzxFbYqQEGYcwCFPFC9AaP2ZBAjGASFiaJzwDHeHCmHHM4zjkcw0ABnQWIlAsgDx6TDaqulJPCY0ZpIUwdSbNuFYhBHqu4lgLyDjuyalHkvX_K_NBEd005jiXlzIjdKw0jpXGsdI6Vn7xCBstG6cKcg2bnUkIjYaYw-IzMuGR7XVMyWEhaaUtbMaC89Ajr8bbuASYug5Uqu5xDM4znsQIR_46Zm6gJI898sSF6cUDhJgDpClHf0wCeBxgJMind6ry1EqRR4gHowQ9Gdv4vLYz5O7-0lw9-1fDl2Tz495Cvl8evntObpsRjpW5TTa6Va9eIFLssh27BPwCma9a4g |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Immune+responses+against+islet+allografts+during+tapering+of+immunosuppression+%E2%80%93+a+pilot+study+in+5+subjects&rft.jtitle=Clinical+and+experimental+immunology&rft.au=Huurman%2C+V.+A.+L.&rft.au=van+der+Torren%2C+C.+R.&rft.au=Gillard%2C+P.&rft.au=Hilbrands%2C+R.&rft.date=2012-08-01&rft.pub=Blackwell+Publishing+Ltd&rft.issn=0009-9104&rft.eissn=1365-2249&rft.volume=169&rft.issue=2&rft.spage=190&rft.epage=198&rft_id=info:doi/10.1111%2Fj.1365-2249.2012.04605.x&rft.externalDBID=10.1111%252Fj.1365-2249.2012.04605.x&rft.externalDocID=CEI4605 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0009-9104&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0009-9104&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0009-9104&client=summon |