Normal ageing is associated with an increase in Th2 cells, MCP‐1 (CCL1) and RANTES (CCL5), with differences in sCD40L and PDGF‐AA between sexes

Summary We have observed T helper type 2 (Th2) polarization of systemic immunity in patients with metastatic malignant melanoma. We hypothesized that similar changes in systemic immunity occur with ageing and may be permissive for the development of melanoma. We analysed the peripheral blood of 389...

Full description

Saved in:
Bibliographic Details
Published inClinical and experimental immunology Vol. 170; no. 2; pp. 186 - 193
Main Authors Mansfield, A. S., Nevala, W. K., Dronca, R. S., Leontovich, A. A., Shuster, L., Markovic, S. N.
Format Journal Article
LanguageEnglish
Published Oxford, UK Blackwell Publishing Ltd 01.11.2012
Blackwell
Oxford University Press
Blackwell Science Inc
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
ageing
Aging
Aging - immunology
Aging - metabolism
Analytical, structural and metabolic biochemistry
Antigens
B-Lymphocyte Subsets - immunology
B-Lymphocyte Subsets - metabolism
Biological and medical sciences
CD3 Complex - immunology
CD3 Complex - metabolism
CD4 Antigens - immunology
CD4 Antigens - metabolism
CD40 Ligand - immunology
CD40 Ligand - metabolism
Chemokine CCL2 - immunology
Chemokine CCL2 - metabolism
Chemokine CCL5 - immunology
Chemokine CCL5 - metabolism
Cytokines - immunology
Cytokines - metabolism
Cytomegalovirus
Cytotoxicity
Fundamental and applied biological sciences. Psychology
Humans
immunity
Influenza
Lymphocytes
Male
MCP‐1
Melanoma
Melanoma - immunology
Melanoma - metabolism
Middle Aged
Original
Platelet-Derived Growth Factor - immunology
Platelet-Derived Growth Factor - metabolism
RANTES
Receptors, Immunologic - immunology
Receptors, Immunologic - metabolism
Receptors, Prostaglandin - immunology
Receptors, Prostaglandin - metabolism
Sex Factors
Skin cancer
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - metabolism
Th2 cells
Th2 Cells - immunology
Th2 Cells - metabolism
Young Adult
MCP-1
RANTES
Ageing
Helper cell
Increase
Biochemistry
CC chemokine
Th2 cells
Immunity
Association
Th2 lymphocyte
Platelet derived growth factor
Monocyte chemoattractant protein 1
Online AccessGet full text

Cover

Abstract Summary We have observed T helper type 2 (Th2) polarization of systemic immunity in patients with metastatic malignant melanoma. We hypothesized that similar changes in systemic immunity occur with ageing and may be permissive for the development of melanoma. We analysed the peripheral blood of 389 healthy blood donors. All subjects were profiled for peripheral blood T cell and B cell subsets, and 58 of these subjects were profiled for antigen‐specific cytotoxic T cell subsets [cytomegalovirus (CMV), influenza and melanoma antigen recognized by T cells 1 (MART‐1)]. Ninety‐five separate healthy subjects underwent profiling of 42 plasma cytokines. Ageing was associated positively with CD4+CD294+ Th2 cells, and associated negatively with CD3+ T cells, cytotoxic T cells and T helper cells. Ageing was also associated negatively with CMV‐, influenza‐ and MART‐1‐specific naive and CD8+ T cells. There were significant increases in plasma monocyte chemotactic protein 1 (MCP‐1) (CCL1) and regulated upon activation normal T cell expressed and secreted (RANTES) (CCL5) with age. We observed differences in cytokine profiles between males and females; specifically, women had higher levels of sCD40L and PDGF‐AA. In summary, we demonstrated in healthy blood donors that ageing was associated with an increase in cellular Th2 bias and a decline in total numbers of T cells. Additionally, there was an increase in MCP‐1 and RANTES with ageing. Women had higher levels of sCD40L and PDGF‐AA than men.
AbstractList Summary We have observed T helper type 2 (Th2) polarization of systemic immunity in patients with metastatic malignant melanoma. We hypothesized that similar changes in systemic immunity occur with ageing and may be permissive for the development of melanoma. We analysed the peripheral blood of 389 healthy blood donors. All subjects were profiled for peripheral blood T cell and B cell subsets, and 58 of these subjects were profiled for antigen-specific cytotoxic T cell subsets [cytomegalovirus (CMV), influenza and melanoma antigen recognized by T cells 1 (MART-1)]. Ninety-five separate healthy subjects underwent profiling of 42 plasma cytokines. Ageing was associated positively with CD4+CD294+ Th2 cells, and associated negatively with CD3+ T cells, cytotoxic T cells and T helper cells. Ageing was also associated negatively with CMV-, influenza- and MART-1-specific naive and CD8+ T cells. There were significant increases in plasma monocyte chemotactic protein 1 (MCP-1) (CCL1) and regulated upon activation normal T cell expressed and secreted (RANTES) (CCL5) with age. We observed differences in cytokine profiles between males and females; specifically, women had higher levels of sCD40L and PDGF-AA. In summary, we demonstrated in healthy blood donors that ageing was associated with an increase in cellular Th2 bias and a decline in total numbers of T cells. Additionally, there was an increase in MCP-1 and RANTES with ageing. Women had higher levels of sCD40L and PDGF-AA than men. [PUBLICATION ABSTRACT]
We have observed T helper type 2 (Th2) polarization of systemic immunity in patients with metastatic malignant melanoma. We hypothesized that similar changes in systemic immunity occur with ageing and may be permissive for the development of melanoma. We analysed the peripheral blood of 389 healthy blood donors. All subjects were profiled for peripheral blood T cell and B cell subsets, and 58 of these subjects were profiled for antigen-specific cytotoxic T cell subsets [cytomegalovirus (CMV), influenza and melanoma antigen recognized by T cells 1 (MART-1)]. Ninety-five separate healthy subjects underwent profiling of 42 plasma cytokines. Ageing was associated positively with CD4(+) CD294(+) Th2 cells, and associated negatively with CD3(+) T cells, cytotoxic T cells and T helper cells. Ageing was also associated negatively with CMV-, influenza- and MART-1-specific naive and CD8(+) T cells. There were significant increases in plasma monocyte chemotactic protein 1 (MCP-1) (CCL1) and regulated upon activation normal T cell expressed and secreted (RANTES) (CCL5) with age. We observed differences in cytokine profiles between males and females; specifically, women had higher levels of sCD40L and PDGF-AA. In summary, we demonstrated in healthy blood donors that ageing was associated with an increase in cellular Th2 bias and a decline in total numbers of T cells. Additionally, there was an increase in MCP-1 and RANTES with ageing. Women had higher levels of sCD40L and PDGF-AA than men.
We have observed T helper type 2 (Th2) polarization of systemic immunity in patients with metastatic malignant melanoma. We hypothesized that similar changes in systemic immunity occur with ageing and may be permissive for the development of melanoma. We analysed the peripheral blood of 389 healthy blood donors. All subjects were profiled for peripheral blood T cell and B cell subsets, and 58 of these subjects were profiled for antigen-specific cytotoxic T cell subsets [cytomegalovirus (CMV), influenza and melanoma antigen recognized by T cells 1 (MART-1)]. Ninety-five separate healthy subjects underwent profiling of 42 plasma cytokines. Ageing was associated positively with CD4 + CD294 + Th2 cells, and associated negatively with CD3 + T cells, cytotoxic T cells and T helper cells. Ageing was also associated negatively with CMV-, influenza- and MART-1-specific naive and CD8 + T cells. There were significant increases in plasma monocyte chemotactic protein 1 (MCP-1) (CCL1) and regulated upon activation normal T cell expressed and secreted (RANTES) (CCL5) with age. We observed differences in cytokine profiles between males and females; specifically, women had higher levels of sCD40L and PDGF-AA. In summary, we demonstrated in healthy blood donors that ageing was associated with an increase in cellular Th2 bias and a decline in total numbers of T cells. Additionally, there was an increase in MCP-1 and RANTES with ageing. Women had higher levels of sCD40L and PDGF-AA than men.
We have observed T helper type 2 (Th2) polarization of systemic immunity in patients with metastatic malignant melanoma. We hypothesized that similar changes in systemic immunity occur with ageing and may be permissive for the development of melanoma. We analysed the peripheral blood of 389 healthy blood donors. All subjects were profiled for peripheral blood T cell and B cell subsets, and 58 of these subjects were profiled for antigen-specific cytotoxic T cell subsets [cytomegalovirus (CMV), influenza and melanoma antigen recognized by T cells 1 (MART-1)]. Ninety-five separate healthy subjects underwent profiling of 42 plasma cytokines. Ageing was associated positively with CD4 super(+)CD294 super(+) Th2 cells, and associated negatively with CD3 super(+) T cells, cytotoxic T cells and T helper cells. Ageing was also associated negatively with CMV-, influenza- and MART-1-specific naive and CD8 super(+) T cells. There were significant increases in plasma monocyte chemotactic protein 1 (MCP-1) (CCL1) and regulated upon activation normal T cell expressed and secreted (RANTES) (CCL5) with age. We observed differences in cytokine profiles between males and females; specifically, women had higher levels of sCD40L and PDGF-AA. In summary, we demonstrated in healthy blood donors that ageing was associated with an increase in cellular Th2 bias and a decline in total numbers of T cells. Additionally, there was an increase in MCP-1 and RANTES with ageing. Women had higher levels of sCD40L and PDGF-AA than men.
We have observed T helper type 2 (Th2) polarization of systemic immunity in patients with metastatic malignant melanoma. We hypothesized that similar changes in systemic immunity occur with ageing and may be permissive for the development of melanoma. We analysed the peripheral blood of 389 healthy blood donors. All subjects were profiled for peripheral blood T cell and B cell subsets, and 58 of these subjects were profiled for antigen-specific cytotoxic T cell subsets [cytomegalovirus (CMV), influenza and melanoma antigen recognized by T cells 1 (MART-1)]. Ninety-five separate healthy subjects underwent profiling of 42 plasma cytokines. Ageing was associated positively with CD4(+) CD294(+) Th2 cells, and associated negatively with CD3(+) T cells, cytotoxic T cells and T helper cells. Ageing was also associated negatively with CMV-, influenza- and MART-1-specific naive and CD8(+) T cells. There were significant increases in plasma monocyte chemotactic protein 1 (MCP-1) (CCL1) and regulated upon activation normal T cell expressed and secreted (RANTES) (CCL5) with age. We observed differences in cytokine profiles between males and females; specifically, women had higher levels of sCD40L and PDGF-AA. In summary, we demonstrated in healthy blood donors that ageing was associated with an increase in cellular Th2 bias and a decline in total numbers of T cells. Additionally, there was an increase in MCP-1 and RANTES with ageing. Women had higher levels of sCD40L and PDGF-AA than men.We have observed T helper type 2 (Th2) polarization of systemic immunity in patients with metastatic malignant melanoma. We hypothesized that similar changes in systemic immunity occur with ageing and may be permissive for the development of melanoma. We analysed the peripheral blood of 389 healthy blood donors. All subjects were profiled for peripheral blood T cell and B cell subsets, and 58 of these subjects were profiled for antigen-specific cytotoxic T cell subsets [cytomegalovirus (CMV), influenza and melanoma antigen recognized by T cells 1 (MART-1)]. Ninety-five separate healthy subjects underwent profiling of 42 plasma cytokines. Ageing was associated positively with CD4(+) CD294(+) Th2 cells, and associated negatively with CD3(+) T cells, cytotoxic T cells and T helper cells. Ageing was also associated negatively with CMV-, influenza- and MART-1-specific naive and CD8(+) T cells. There were significant increases in plasma monocyte chemotactic protein 1 (MCP-1) (CCL1) and regulated upon activation normal T cell expressed and secreted (RANTES) (CCL5) with age. We observed differences in cytokine profiles between males and females; specifically, women had higher levels of sCD40L and PDGF-AA. In summary, we demonstrated in healthy blood donors that ageing was associated with an increase in cellular Th2 bias and a decline in total numbers of T cells. Additionally, there was an increase in MCP-1 and RANTES with ageing. Women had higher levels of sCD40L and PDGF-AA than men.
Summary We have observed T helper type 2 (Th2) polarization of systemic immunity in patients with metastatic malignant melanoma. We hypothesized that similar changes in systemic immunity occur with ageing and may be permissive for the development of melanoma. We analysed the peripheral blood of 389 healthy blood donors. All subjects were profiled for peripheral blood T cell and B cell subsets, and 58 of these subjects were profiled for antigen‐specific cytotoxic T cell subsets [cytomegalovirus (CMV), influenza and melanoma antigen recognized by T cells 1 (MART‐1)]. Ninety‐five separate healthy subjects underwent profiling of 42 plasma cytokines. Ageing was associated positively with CD4+CD294+ Th2 cells, and associated negatively with CD3+ T cells, cytotoxic T cells and T helper cells. Ageing was also associated negatively with CMV‐, influenza‐ and MART‐1‐specific naive and CD8+ T cells. There were significant increases in plasma monocyte chemotactic protein 1 (MCP‐1) (CCL1) and regulated upon activation normal T cell expressed and secreted (RANTES) (CCL5) with age. We observed differences in cytokine profiles between males and females; specifically, women had higher levels of sCD40L and PDGF‐AA. In summary, we demonstrated in healthy blood donors that ageing was associated with an increase in cellular Th2 bias and a decline in total numbers of T cells. Additionally, there was an increase in MCP‐1 and RANTES with ageing. Women had higher levels of sCD40L and PDGF‐AA than men.
Author Dronca, R. S.
Leontovich, A. A.
Mansfield, A. S.
Nevala, W. K.
Markovic, S. N.
Shuster, L.
Author_xml – sequence: 1
  givenname: A. S.
  surname: Mansfield
  fullname: Mansfield, A. S.
– sequence: 2
  givenname: W. K.
  surname: Nevala
  fullname: Nevala, W. K.
– sequence: 3
  givenname: R. S.
  surname: Dronca
  fullname: Dronca, R. S.
– sequence: 4
  givenname: A. A.
  surname: Leontovich
  fullname: Leontovich, A. A.
– sequence: 5
  givenname: L.
  surname: Shuster
  fullname: Shuster, L.
– sequence: 6
  givenname: S. N.
  surname: Markovic
  fullname: Markovic, S. N.
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26450388$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/23039889$$D View this record in MEDLINE/PubMed
BookMark eNqNks9u00AQxi1URNPCK6CVEFIr1WH_OruHIkVuWiqFUkE4r9brcbKRYxevQ9Ibj4DEG_IkrJO0hV6oL57d-eY34_F3EO1VdQVRhAjuk_C8m_cJS0RMKVd9igntY55w3l8_i3r3ib2ohzFWsSKY70cH3s_DMUkS-iLapwwzJaXqRb-u6mZhSmSm4Kopch4Z72vrTAs5Wrl2hkyFXGUbMB5CgCYziiyUpT9BH9Pr3z9-EnSUpmNyHIQ5-jy8moy-bG7E8ckWkLuigAYqC74D-PSM4_FGfX12cR4IwyHKoF0BhCSswb-Mnhem9PBq9z6Mvp6PJumHePzp4jIdjmMrEsFjYxlkQIFkSkmTKQMmJ8omMGBWZtLkWZ5xyHJQgAsgA5onQijOAEspJCvYYfR-y71ZZgvILVRtY0p907iFaW51bZz-N1O5mZ7W3zXjkoY1B8DRDtDU35bgW71wvluOqaBeek2E4KGh5Oz_UqwEF5woFaRvHknn9bKpwiY2QK4Gina9X_89_P3Ud782CN7uBMZbUxaNqazzD7qEC8ykfNiCbWrvGyi0da1pXd19syvDZLrznJ7rzlq6s5buPKc3ntPrAJCPAHc9nlB6ui1duRJun1yn09FlF7E_cRvsTg
CODEN CEXIAL
CitedBy_id crossref_primary_10_1016_j_jinorgbio_2015_07_004
crossref_primary_10_1152_ajpcell_00402_2014
crossref_primary_10_1097_DER_0000000000000686
crossref_primary_10_1016_j_nbd_2023_106202
crossref_primary_10_1007_s40520_013_0190_y
crossref_primary_10_18632_oncotarget_8796
crossref_primary_10_1016_j_exger_2020_110837
crossref_primary_10_1016_j_ijcard_2016_11_118
crossref_primary_10_14336_AD_2017_0110
crossref_primary_10_1038_s41598_018_36825_y
crossref_primary_10_1097_MOH_0000000000000526
crossref_primary_10_1177_1352458518775550
crossref_primary_10_3389_fphys_2022_816774
crossref_primary_10_1093_gerona_glaa310
crossref_primary_10_1007_s11427_024_2695_x
crossref_primary_10_1111_acel_12706
crossref_primary_10_5582_irdr_2015_01035
crossref_primary_10_1093_gerona_gly117
crossref_primary_10_1111_cea_13891
crossref_primary_10_3390_diagnostics10030177
crossref_primary_10_1016_j_cger_2023_09_010
crossref_primary_10_1016_j_bcp_2021_114723
crossref_primary_10_1016_j_jim_2024_113731
crossref_primary_10_1016_j_pharmthera_2023_108560
crossref_primary_10_1097_CMR_0b013e32835e5880
crossref_primary_10_3389_fimmu_2024_1410090
crossref_primary_10_3390_cells12030368
crossref_primary_10_1007_s00394_016_1281_2
crossref_primary_10_1016_j_jcv_2015_06_088
crossref_primary_10_3390_v14071493
crossref_primary_10_1007_s11357_019_00099_7
crossref_primary_10_1016_j_archger_2024_105376
crossref_primary_10_1051_medsci_20173302012
crossref_primary_10_1007_s00417_024_06417_w
crossref_primary_10_1016_j_cyto_2018_03_012
crossref_primary_10_1016_j_mayocp_2014_01_006
crossref_primary_10_1016_j_clnesp_2020_05_024
crossref_primary_10_1016_j_bbr_2015_04_040
crossref_primary_10_3390_nu13030886
crossref_primary_10_1186_1742_4933_10_22
crossref_primary_10_3389_fimmu_2023_1285069
crossref_primary_10_1038_cdd_2015_21
crossref_primary_10_1007_s10522_019_09811_8
crossref_primary_10_1002_cam4_1152
crossref_primary_10_1016_j_cyto_2016_05_009
crossref_primary_10_3389_fimmu_2017_00784
crossref_primary_10_3389_fragi_2021_748591
crossref_primary_10_3390_v14102145
crossref_primary_10_3390_antiox10060856
crossref_primary_10_1016_j_cyto_2020_155142
crossref_primary_10_1080_21678421_2021_1912100
crossref_primary_10_1189_jlb_5A0116_025R
crossref_primary_10_1111_jgs_15393
crossref_primary_10_1186_s12885_018_4920_6
crossref_primary_10_4110_in_2019_19_e37
crossref_primary_10_1016_j_pharmthera_2018_08_014
crossref_primary_10_1507_endocrj_EJ22_0611
crossref_primary_10_1177_1076029617747412
crossref_primary_10_3389_fimmu_2017_01962
crossref_primary_10_7717_peerj_1854
Cites_doi 10.4049/jimmunol.167.7.3765
10.4049/jimmunol.161.9.5027
10.1046/j.1365-2567.2000.00047.x
10.1016/S0015-0282(00)00622-1
10.1111/j.1365-2567.2008.02966.x
10.1186/1479-5876-9-113
10.1038/jid.2010.354
10.1089/107999099313127
10.1016/0014-4827(61)90192-6
10.1073/pnas.91.9.3652
10.1158/1078-0432.CCR-0348-03
10.1158/1078-0432.CCR-08-1980
10.1016/j.maturitas.2006.11.002
10.1002/eji.1830260207
10.1056/NEJMoa022600
10.1093/gerona/glp198
10.1084/jem.184.2.747
10.1038/nature03954
10.1016/S0531-5565(01)00187-5
10.4049/jimmunol.156.6.2095
10.1046/j.1365-2133.1996.d01-1092.x
10.1016/j.cger.2011.07.001
10.1016/S0047-6374(00)00195-0
10.1016/0014-4827(65)90211-9
10.1111/j.1399-3038.2005.00363.x
10.1016/j.exger.2007.06.008
10.1016/j.mad.2006.01.014
10.1111/j.1749-6632.2009.05370.x
10.1016/S0531-5565(03)00160-8
10.1073/pnas.88.12.5360
10.1084/jem.185.9.1595
10.1097/00042192-200107000-00008
10.1016/j.coi.2011.05.002
10.1038/modpathol.2010.227
ContentType Journal Article
Copyright 2012 British Society for Immunology
2015 INIST-CNRS
2012 British Society for Immunology.
Copyright © 2012 British Society for Immunology
Copyright © 2012 British Society for Immunology 2012
Copyright_xml – notice: 2012 British Society for Immunology
– notice: 2015 INIST-CNRS
– notice: 2012 British Society for Immunology.
– notice: Copyright © 2012 British Society for Immunology
– notice: Copyright © 2012 British Society for Immunology 2012
DBID AAYXX
CITATION
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
7T5
7U9
H94
M7N
7X8
5PM
DOI 10.1111/j.1365-2249.2012.04644.x
DatabaseName CrossRef
Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
Immunology Abstracts
Virology and AIDS Abstracts
AIDS and Cancer Research Abstracts
Algology Mycology and Protozoology Abstracts (Microbiology C)
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
AIDS and Cancer Research Abstracts
Immunology Abstracts
Virology and AIDS Abstracts
Algology Mycology and Protozoology Abstracts (Microbiology C)
MEDLINE - Academic
DatabaseTitleList AIDS and Cancer Research Abstracts
MEDLINE

AIDS and Cancer Research Abstracts
MEDLINE - Academic

CrossRef
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: EIF
  name: MEDLINE
  url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search
  sourceTypes: Index Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Biology
EISSN 1365-2249
EndPage 193
ExternalDocumentID PMC3482365
3407665001
23039889
26450388
10_1111_j_1365_2249_2012_04644_x
CEI4644
Genre article
Journal Article
GroupedDBID ---
.3N
.55
.GA
.GJ
.Y3
05W
0R~
10A
169
1OC
24P
29B
2WC
31~
33P
36B
3O-
3SF
4.4
50Y
50Z
51W
51X
52M
52N
52O
52P
52R
52S
52T
52U
52V
52W
52X
53G
5GY
5HH
5LA
5VS
5WD
66C
6J9
702
7PT
8-0
8-1
8-3
8-4
8-5
8UM
930
A01
A03
A8Z
AABZA
AACZT
AAESR
AAEVG
AAHHS
AAONW
AAPXW
AARHZ
AAUAY
AAVAP
AAZKR
ABCQN
ABCUV
ABDBF
ABDFA
ABEJV
ABEML
ABJNI
ABLJU
ABNHQ
ABOCM
ABPTD
ABPVW
ABQNK
ABXVV
ACAHQ
ACCFJ
ACFBH
ACGFO
ACGFS
ACMXC
ACPOU
ACPRK
ACSCC
ACUFI
ACUHS
ACXQS
ADBBV
ADEOM
ADIPN
ADIYS
ADIZJ
ADKYN
ADMGS
ADOZA
ADQBN
ADVEK
ADXAS
ADZMN
ADZOD
AEEZP
AEGXH
AEIMD
AENEX
AEQDE
AEUQT
AFBPY
AFEBI
AFFZL
AFGKR
AFPWT
AFRAH
AFTUV
AFXAL
AFZJQ
AGMDO
AGUTN
AHMMS
AIACR
AIAGR
AIURR
AIWBW
AJAOE
AJBDE
AJEEA
ALAGY
ALMA_UNASSIGNED_HOLDINGS
AMBMR
AMYDB
AOIJS
ATGXG
ATUGU
AZBYB
AZVAB
BAFTC
BAWUL
BCRHZ
BEYMZ
BHBCM
BMXJE
BROTX
BRXPI
BY8
C45
CAG
COF
D-6
D-7
D-E
D-F
DCZOG
DIK
DPXWK
DR2
DRFUL
DRMAN
DRSTM
DU5
E3Z
EAD
EAP
EAS
EBB
EBC
EBD
EBS
EBX
EJD
EMB
EMK
EMOBN
ESX
EX3
F00
F01
F04
F5P
FIJ
FUBAC
G-S
G.N
GODZA
GX1
H.X
H13
HF~
HZI
HZ~
IH2
IHE
IPNFZ
IX1
J0M
J5H
K48
KBUDW
KBYEO
KOP
KSI
KSN
LATKE
LC2
LC3
LEEKS
LH4
LITHE
LOXES
LP6
LP7
LUTES
LW6
LYRES
MK4
MRFUL
MRMAN
MRSTM
MSFUL
MSMAN
MSSTM
MXFUL
MXMAN
MXSTM
N04
N05
N9A
NF~
NOMLY
NU-
O66
O9-
OAUYM
OBS
OCZFY
OHT
OIG
OJZSN
OK1
OPAEJ
OVD
OWPYF
P2P
P2W
P2X
P2Z
P4B
P4D
Q.N
Q11
QB0
Q~Q
R.K
ROL
ROX
RPM
RX1
SUPJJ
SV3
TEORI
TR2
TUS
UB1
V8K
W8V
W99
WBKPD
WHWMO
WIH
WIJ
WIK
WIN
WOHZO
WOQ
WOW
WQJ
WRC
WVDHM
WXI
X7M
XG1
Y6R
YFH
YOC
YUY
ZGI
ZXP
ZZTAW
~IA
~KM
~WT
AAFWJ
AAYXX
ABGNP
ABVGC
AEMQT
AGORE
AJBYB
AJNCP
ALXQX
CITATION
AAMMB
ACVCV
AEFGJ
AFFQV
AGXDD
AHGBF
AIDQK
AIDYY
AJDVS
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
7T5
7U9
H94
M7N
7X8
5PM
ID FETCH-LOGICAL-c5654-ac3ebe2e1b998ab9aead19c6e73c8b8adbdb4ebde9e0fe172d655943e088583f3
IEDL.DBID DR2
ISSN 0009-9104
1365-2249
IngestDate Thu Aug 21 13:47:38 EDT 2025
Tue Aug 05 11:25:20 EDT 2025
Fri Jul 11 06:46:48 EDT 2025
Wed Aug 13 02:49:52 EDT 2025
Mon Jul 21 06:01:42 EDT 2025
Mon Jul 21 09:12:48 EDT 2025
Thu Apr 24 23:06:20 EDT 2025
Tue Jul 01 03:52:39 EDT 2025
Wed Jan 22 16:43:27 EST 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords MCP-1
RANTES
Ageing
Helper cell
Increase
Biochemistry
CC chemokine
Th2 cells
Immunity
Association
Th2 lymphocyte
Platelet derived growth factor
Monocyte chemoattractant protein 1
Language English
License https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model
CC BY 4.0
2012 British Society for Immunology.
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c5654-ac3ebe2e1b998ab9aead19c6e73c8b8adbdb4ebde9e0fe172d655943e088583f3
Notes ASM and WKN are co‐primary authors.
ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
ASM and WKN are co-primary authors.
OpenAccessLink https://www.ncbi.nlm.nih.gov/pmc/articles/3482365
PMID 23039889
PQID 1554497925
PQPubID 36527
PageCount 8
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_3482365
proquest_miscellaneous_1554943843
proquest_miscellaneous_1095454199
proquest_journals_1554497925
pubmed_primary_23039889
pascalfrancis_primary_26450388
crossref_citationtrail_10_1111_j_1365_2249_2012_04644_x
crossref_primary_10_1111_j_1365_2249_2012_04644_x
wiley_primary_10_1111_j_1365_2249_2012_04644_x_CEI4644
ProviderPackageCode CITATION
AAYXX
PublicationCentury 2000
PublicationDate November 2012
PublicationDateYYYYMMDD 2012-11-01
PublicationDate_xml – month: 11
  year: 2012
  text: November 2012
PublicationDecade 2010
PublicationPlace Oxford, UK
PublicationPlace_xml – name: Oxford, UK
– name: Oxford
– name: England
PublicationTitle Clinical and experimental immunology
PublicationTitleAlternate Clin Exp Immunol
PublicationYear 2012
Publisher Blackwell Publishing Ltd
Blackwell
Oxford University Press
Blackwell Science Inc
Publisher_xml – name: Blackwell Publishing Ltd
– name: Blackwell
– name: Oxford University Press
– name: Blackwell Science Inc
References 2001; 167
2002; 37
2006; 17
2005; 437
1996; 184
2003; 38
1965; 37
2010; 1197
2007; 56
2011; 131
2011; 9
2004; 10
2010; 65
2003; 348
1999; 19
1991; 88
1997; 185
2000; 74
2001; 8
2011; 24
2008; 43
2011; 23
2000; 121
2000; 100
1996; 81
2006; 127
2011; 27
1994; 91
1996; 135
1961; 25
1996; 26
1996; 156
2009; 15
1998; 161
2009; 128
Qiu (2021122708262113200_b13) 2009; 128
Buchholz (2021122708262113200_b12) 2011; 23
Barnhill (2021122708262113200_b22) 1996; 135
Kim (2021122708262113200_b27) 2011; 9
Andrew (2021122708262113200_b17) 1998; 161
Hayflick (2021122708262113200_b1) 1965; 37
Vidalain (2021122708262113200_b19) 2001; 167
Stowe (2021122708262113200_b26) 2010; 65
Yasui (2021122708262113200_b31) 2007; 56
Cella (2021122708262113200_b18) 1996; 184
Heeschen (2021122708262113200_b20) 2003; 348
Nevala (2021122708262113200_b7) 2009; 15
Alberti (2021122708262113200_b24) 2006; 127
Zanni (2021122708262113200_b25) 2003; 38
Willimsky (2021122708262113200_b5) 2005; 437
Maghazachi (2021122708262113200_b14) 1996; 26
Hayflick (2021122708262113200_b2) 1961; 25
Mariani (2021122708262113200_b30) 2002; 37
Kawamoto (2021122708262113200_b9) 2006; 17
Verthelyi (2021122708262113200_b33) 2000; 100
Harman (2021122708262113200_b4) 1991; 88
Gerli (2021122708262113200_b28) 2000; 121
Mansfield (2021122708262113200_b8) 2011; 24
Yang (2021122708262113200_b34) 2000; 74
Carr (2021122708262113200_b11) 1994; 91
Taub (2021122708262113200_b15) 1996; 156
Godiska (2021122708262113200_b16) 1997; 185
Roselli (2021122708262113200_b21) 2004; 10
Fulop (2021122708262113200_b6) 2010; 1197
Inadera (2021122708262113200_b29) 1999; 19
Deguchi (2021122708262113200_b32) 2001; 8
Cefalu (2021122708262113200_b3) 2011; 27
Kassem (2021122708262113200_b35) 1996; 81
Joosse (2021122708262113200_b10) 2011; 131
Sansoni (2021122708262113200_b23) 2008; 43
11564793 - J Immunol. 2001 Oct 1;167(7):3765-72
14760083 - Clin Cancer Res. 2004 Jan 15;10(2):610-4
16516272 - Mech Ageing Dev. 2006 Jun;127(6):560-6
21774806 - J Transl Med. 2011;9:113
21150923 - J Invest Dermatol. 2011 Mar;131(3):719-26
22062437 - Clin Geriatr Med. 2011 Nov;27(4):491-506
2052612 - Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5360-3
11772507 - Exp Gerontol. 2002 Jan-Mar;37(2-3):219-26
20536845 - Ann N Y Acad Sci. 2010 Jun;1197:158-65
9794440 - J Immunol. 1998 Nov 1;161(9):5027-38
10927042 - Fertil Steril. 2000 Aug;74(2):261-7
17870272 - Exp Gerontol. 2008 Feb;43(2):61-5
19016906 - Immunology. 2009 Sep;128(1 Suppl):e325-34
16618362 - Pediatr Allergy Immunol. 2006 Mar;17(2):125-33
8690897 - J Immunol. 1996 Mar 15;156(6):2095-2103
21151098 - Mod Pathol. 2011 Apr;24(4):487-94
20018825 - J Gerontol A Biol Sci Med Sci. 2010 Apr;65(4):429-33
14315085 - Exp Cell Res. 1965 Mar;37:614-36
8636260 - J Clin Endocrinol Metab. 1996 Feb;81(2):513-8
19240164 - Clin Cancer Res. 2009 Mar 15;15(6):1931-9
13905658 - Exp Cell Res. 1961 Dec;25:585-621
11449084 - Menopause. 2001 Jul-Aug;8(4):266-73
8977709 - Br J Dermatol. 1996 Dec;135(6):898-904
8170963 - Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3652-6
9151897 - J Exp Med. 1997 May 5;185(9):1595-604
12954485 - Exp Gerontol. 2003 Sep;38(9):981-7
10547158 - J Interferon Cytokine Res. 1999 Oct;19(10):1179-82
10929062 - Immunology. 2000 Jul;100(3):384-90
11164458 - Mech Ageing Dev. 2000 Dec 20;121(1-3):37-46
16136144 - Nature. 2005 Sep 1;437(7055):141-6
12646667 - N Engl J Med. 2003 Mar 20;348(12):1104-11
21664807 - Curr Opin Immunol. 2011 Aug;23(4):549-54
8617297 - Eur J Immunol. 1996 Feb;26(2):315-9
8760829 - J Exp Med. 1996 Aug 1;184(2):747-52
17164077 - Maturitas. 2007 Apr 20;56(4):396-403
References_xml – volume: 91
  start-page: 3652
  year: 1994
  end-page: 6
  article-title: Monocyte chemoattractant protein 1 acts as a T‐lymphocyte chemoattractant
  publication-title: Proc Natl Acad Sci USA
– volume: 156
  start-page: 2095
  year: 1996
  end-page: 103
  article-title: Chemokines and T lymphocyte activation: I. Beta chemokines costimulate human T lymphocyte activation
  publication-title: J Immunol
– volume: 161
  start-page: 5027
  year: 1998
  end-page: 38
  article-title: STCP‐1 (MDC) CC chemokine acts specifically on chronically activated Th2 lymphocytes and is produced by monocytes on stimulation with Th2 cytokines IL‐4 and IL‐13
  publication-title: J Immunol
– volume: 348
  start-page: 1104
  year: 2003
  end-page: 11
  article-title: Soluble CD40 ligand in acute coronary syndromes
  publication-title: N Engl J Med
– volume: 81
  start-page: 513
  year: 1996
  end-page: 8
  article-title: Cytokine production in the bone marrow microenvironment: failure to demonstrate estrogen regulation in early postmenopausal women
  publication-title: J Clin Endocrinol Metab
– volume: 27
  start-page: 491
  year: 2011
  end-page: 506
  article-title: Theories and mechanisms of aging
  publication-title: Clin Geriatr Med
– volume: 121
  start-page: 37
  year: 2000
  end-page: 46
  article-title: Chemokines, sTNF‐Rs and sCD30 serum levels in healthy aged people and centenarians
  publication-title: Mech Ageing Dev
– volume: 127
  start-page: 560
  year: 2006
  end-page: 6
  article-title: Age‐dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4+ T cells in humans
  publication-title: Mech Ageing Dev
– volume: 185
  start-page: 1595
  year: 1997
  end-page: 604
  article-title: Human macrophage‐derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte‐derived dendritic cells, and natural killer cells
  publication-title: J Exp Med
– volume: 25
  start-page: 585
  year: 1961
  end-page: 621
  article-title: The serial cultivation of human diploid cell strains
  publication-title: Exp Cell Res
– volume: 135
  start-page: 898
  year: 1996
  end-page: 904
  article-title: Expression of platelet‐derived growth factor (PDGF)‐A, PDGF‐B and the PDGF‐alpha receptor, but not the PDGF‐beta receptor, in human malignant melanoma
  publication-title: Br J Dermatol
– volume: 1197
  start-page: 158
  year: 2010
  end-page: 65
  article-title: Potential role of immunosenescence in cancer development
  publication-title: Ann NY Acad Sci
– volume: 17
  start-page: 125
  year: 2006
  end-page: 33
  article-title: Age‐related changes in intracellular cytokine profiles and Th2 dominance in allergic children
  publication-title: Pediatr Allergy Immunol
– volume: 9
  start-page: 113
  year: 2011
  article-title: Serum cytokine profiles in healthy young and elderly population assessed using multiplexed bead‐based immunoassays
  publication-title: J Transl Med
– volume: 56
  start-page: 396
  year: 2007
  end-page: 403
  article-title: Changes in serum cytokine concentrations during the menopausal transition
  publication-title: Maturitas
– volume: 74
  start-page: 261
  year: 2000
  end-page: 7
  article-title: Hormone replacement therapy reverses the decrease in natural killer cytotoxicity but does not reverse the decreases in the T‐cell subpopulation or interferon‐gamma production in postmenopausal women
  publication-title: Fertil Steril
– volume: 43
  start-page: 61
  year: 2008
  end-page: 5
  article-title: The immune system in extreme longevity
  publication-title: Exp Gerontol
– volume: 24
  start-page: 487
  year: 2011
  end-page: 94
  article-title: Regional immunity in melanoma: immunosuppressive changes precede nodal metastasis
  publication-title: Mod Pathol
– volume: 65
  start-page: 429
  year: 2010
  end-page: 33
  article-title: Plasma cytokine levels in a population‐based study: relation to age and ethnicity
  publication-title: J Gerontol A Biol Sci Med Sci
– volume: 131
  start-page: 719
  year: 2011
  end-page: 26
  article-title: Gender differences in melanoma survival: female patients have a decreased risk of metastasis
  publication-title: J Invest Dermatol
– volume: 167
  start-page: 3765
  year: 2001
  end-page: 72
  article-title: Cytotoxic activity of human dendritic cells is differentially regulated by double‐stranded RNA and CD40 ligand
  publication-title: J Immunol
– volume: 10
  start-page: 610
  year: 2004
  end-page: 4
  article-title: Soluble CD40 ligand plasma levels in lung cancer
  publication-title: Clin Cancer Res
– volume: 23
  start-page: 549
  year: 2011
  end-page: 54
  article-title: CD8+ T cell differentiation in the aging immune system: until the last clone standing
  publication-title: Curr Opin Immunol
– volume: 8
  start-page: 266
  year: 2001
  end-page: 73
  article-title: Postmenopausal changes in production of type 1 and type 2 cytokines and the effects of hormone replacement therapy
  publication-title: Menopause
– volume: 437
  start-page: 141
  year: 2005
  end-page: 6
  article-title: Sporadic immunogenic tumours avoid destruction by inducing T‐cell tolerance
  publication-title: Nature
– volume: 88
  start-page: 5360
  year: 1991
  end-page: 3
  article-title: The aging process: major risk factor for disease and death
  publication-title: Proc Natl Acad Sci USA
– volume: 100
  start-page: 384
  year: 2000
  end-page: 90
  article-title: Sex hormone levels correlate with the activity of cytokine‐secreting cells
  publication-title: Immunology
– volume: 15
  start-page: 1931
  year: 2009
  end-page: 9
  article-title: Evidence of systemic Th2‐driven chronic inflammation in patients with metastatic melanoma
  publication-title: Clin Cancer Res
– volume: 184
  start-page: 747
  year: 1996
  end-page: 52
  article-title: Ligation of CD40 on dendritic cells triggers production of high levels of interleukin‐12 and enhances T cell stimulatory capacity: T‐T help via APC activation
  publication-title: J Exp Med
– volume: 38
  start-page: 981
  year: 2003
  end-page: 7
  article-title: Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence
  publication-title: Exp Gerontol
– volume: 19
  start-page: 1179
  year: 1999
  end-page: 82
  article-title: Increase in circulating levels of monocyte chemoattractant protein‐1 with aging
  publication-title: J Interferon Cytokine Res
– volume: 37
  start-page: 219
  year: 2002
  end-page: 26
  article-title: RANTES and MIP‐1alpha production by T lymphocytes, monocytes and NK cells from nonagenarian subjects
  publication-title: Exp Gerontol
– volume: 37
  start-page: 614
  year: 1965
  end-page: 36
  article-title: The limited lifetime of human diploid cell strains
  publication-title: Exp Cell Res
– volume: 26
  start-page: 315
  year: 1996
  end-page: 9
  article-title: CC chemokines induce the generation of killer cells from CD56+ cells
  publication-title: Eur J Immunol
– volume: 128
  start-page: e325
  year: 2009
  end-page: 34
  article-title: Induction of copper/zinc‐superoxide dismutase by CCL5/CCR5 activation causes tumour necrosis factor‐alpha and reactive oxygen species production in macrophages
  publication-title: Immunology
– volume: 167
  start-page: 3765
  year: 2001
  ident: 2021122708262113200_b19
  article-title: Cytotoxic activity of human dendritic cells is differentially regulated by double-stranded RNA and CD40 ligand
  publication-title: J Immunol
  doi: 10.4049/jimmunol.167.7.3765
– volume: 161
  start-page: 5027
  year: 1998
  ident: 2021122708262113200_b17
  article-title: STCP-1 (MDC) CC chemokine acts specifically on chronically activated Th2 lymphocytes and is produced by monocytes on stimulation with Th2 cytokines IL-4 and IL-13
  publication-title: J Immunol
  doi: 10.4049/jimmunol.161.9.5027
– volume: 100
  start-page: 384
  year: 2000
  ident: 2021122708262113200_b33
  article-title: Sex hormone levels correlate with the activity of cytokine-secreting cells in vivo
  publication-title: Immunology
  doi: 10.1046/j.1365-2567.2000.00047.x
– volume: 74
  start-page: 261
  year: 2000
  ident: 2021122708262113200_b34
  article-title: Hormone replacement therapy reverses the decrease in natural killer cytotoxicity but does not reverse the decreases in the T-cell subpopulation or interferon-gamma production in postmenopausal women
  publication-title: Fertil Steril
  doi: 10.1016/S0015-0282(00)00622-1
– volume: 128
  start-page: e325
  year: 2009
  ident: 2021122708262113200_b13
  article-title: Induction of copper/zinc-superoxide dismutase by CCL5/CCR5 activation causes tumour necrosis factor-alpha and reactive oxygen species production in macrophages
  publication-title: Immunology
  doi: 10.1111/j.1365-2567.2008.02966.x
– volume: 9
  start-page: 113
  year: 2011
  ident: 2021122708262113200_b27
  article-title: Serum cytokine profiles in healthy young and elderly population assessed using multiplexed bead-based immunoassays
  publication-title: J Transl Med
  doi: 10.1186/1479-5876-9-113
– volume: 131
  start-page: 719
  year: 2011
  ident: 2021122708262113200_b10
  article-title: Gender differences in melanoma survival: female patients have a decreased risk of metastasis
  publication-title: J Invest Dermatol
  doi: 10.1038/jid.2010.354
– volume: 19
  start-page: 1179
  year: 1999
  ident: 2021122708262113200_b29
  article-title: Increase in circulating levels of monocyte chemoattractant protein-1 with aging
  publication-title: J Interferon Cytokine Res
  doi: 10.1089/107999099313127
– volume: 25
  start-page: 585
  year: 1961
  ident: 2021122708262113200_b2
  article-title: The serial cultivation of human diploid cell strains
  publication-title: Exp Cell Res
  doi: 10.1016/0014-4827(61)90192-6
– volume: 91
  start-page: 3652
  year: 1994
  ident: 2021122708262113200_b11
  article-title: Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.91.9.3652
– volume: 10
  start-page: 610
  year: 2004
  ident: 2021122708262113200_b21
  article-title: Soluble CD40 ligand plasma levels in lung cancer
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-0348-03
– volume: 15
  start-page: 1931
  year: 2009
  ident: 2021122708262113200_b7
  article-title: Evidence of systemic Th2-driven chronic inflammation in patients with metastatic melanoma
  publication-title: Clin Cancer Res
  doi: 10.1158/1078-0432.CCR-08-1980
– volume: 56
  start-page: 396
  year: 2007
  ident: 2021122708262113200_b31
  article-title: Changes in serum cytokine concentrations during the menopausal transition
  publication-title: Maturitas
  doi: 10.1016/j.maturitas.2006.11.002
– volume: 26
  start-page: 315
  year: 1996
  ident: 2021122708262113200_b14
  article-title: CC chemokines induce the generation of killer cells from CD56+ cells
  publication-title: Eur J Immunol
  doi: 10.1002/eji.1830260207
– volume: 348
  start-page: 1104
  year: 2003
  ident: 2021122708262113200_b20
  article-title: Soluble CD40 ligand in acute coronary syndromes
  publication-title: N Engl J Med
  doi: 10.1056/NEJMoa022600
– volume: 65
  start-page: 429
  year: 2010
  ident: 2021122708262113200_b26
  article-title: Plasma cytokine levels in a population-based study: relation to age and ethnicity
  publication-title: J Gerontol A Biol Sci Med Sci
  doi: 10.1093/gerona/glp198
– volume: 184
  start-page: 747
  year: 1996
  ident: 2021122708262113200_b18
  article-title: Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
  publication-title: J Exp Med
  doi: 10.1084/jem.184.2.747
– volume: 437
  start-page: 141
  year: 2005
  ident: 2021122708262113200_b5
  article-title: Sporadic immunogenic tumours avoid destruction by inducing T-cell tolerance
  publication-title: Nature
  doi: 10.1038/nature03954
– volume: 37
  start-page: 219
  year: 2002
  ident: 2021122708262113200_b30
  article-title: RANTES and MIP-1alpha production by T lymphocytes, monocytes and NK cells from nonagenarian subjects
  publication-title: Exp Gerontol
  doi: 10.1016/S0531-5565(01)00187-5
– volume: 156
  start-page: 2095
  year: 1996
  ident: 2021122708262113200_b15
  article-title: Chemokines and T lymphocyte activation: I. Beta chemokines costimulate human T lymphocyte activation in vitro
  publication-title: J Immunol
  doi: 10.4049/jimmunol.156.6.2095
– volume: 135
  start-page: 898
  year: 1996
  ident: 2021122708262113200_b22
  article-title: Expression of platelet-derived growth factor (PDGF)-A, PDGF-B and the PDGF-alpha receptor, but not the PDGF-beta receptor, in human malignant melanoma in vivo
  publication-title: Br J Dermatol
  doi: 10.1046/j.1365-2133.1996.d01-1092.x
– volume: 27
  start-page: 491
  year: 2011
  ident: 2021122708262113200_b3
  article-title: Theories and mechanisms of aging
  publication-title: Clin Geriatr Med
  doi: 10.1016/j.cger.2011.07.001
– volume: 121
  start-page: 37
  year: 2000
  ident: 2021122708262113200_b28
  article-title: Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians
  publication-title: Mech Ageing Dev
  doi: 10.1016/S0047-6374(00)00195-0
– volume: 37
  start-page: 614
  year: 1965
  ident: 2021122708262113200_b1
  article-title: The limited in vitro lifetime of human diploid cell strains
  publication-title: Exp Cell Res
  doi: 10.1016/0014-4827(65)90211-9
– volume: 17
  start-page: 125
  year: 2006
  ident: 2021122708262113200_b9
  article-title: Age-related changes in intracellular cytokine profiles and Th2 dominance in allergic children
  publication-title: Pediatr Allergy Immunol
  doi: 10.1111/j.1399-3038.2005.00363.x
– volume: 43
  start-page: 61
  year: 2008
  ident: 2021122708262113200_b23
  article-title: The immune system in extreme longevity
  publication-title: Exp Gerontol
  doi: 10.1016/j.exger.2007.06.008
– volume: 127
  start-page: 560
  year: 2006
  ident: 2021122708262113200_b24
  article-title: Age-dependent modifications of Type 1 and Type 2 cytokines within virgin and memory CD4+ T cells in humans
  publication-title: Mech Ageing Dev
  doi: 10.1016/j.mad.2006.01.014
– volume: 1197
  start-page: 158
  year: 2010
  ident: 2021122708262113200_b6
  article-title: Potential role of immunosenescence in cancer development
  publication-title: Ann NY Acad Sci
  doi: 10.1111/j.1749-6632.2009.05370.x
– volume: 38
  start-page: 981
  year: 2003
  ident: 2021122708262113200_b25
  article-title: Marked increase with age of type 1 cytokines within memory and effector/cytotoxic CD8+ T cells in humans: a contribution to understand the relationship between inflammation and immunosenescence
  publication-title: Exp Gerontol
  doi: 10.1016/S0531-5565(03)00160-8
– volume: 88
  start-page: 5360
  year: 1991
  ident: 2021122708262113200_b4
  article-title: The aging process: major risk factor for disease and death
  publication-title: Proc Natl Acad Sci USA
  doi: 10.1073/pnas.88.12.5360
– volume: 81
  start-page: 513
  year: 1996
  ident: 2021122708262113200_b35
  article-title: Cytokine production in the bone marrow microenvironment: failure to demonstrate estrogen regulation in early postmenopausal women
  publication-title: J Clin Endocrinol Metab
– volume: 185
  start-page: 1595
  year: 1997
  ident: 2021122708262113200_b16
  article-title: Human macrophage-derived chemokine (MDC), a novel chemoattractant for monocytes, monocyte-derived dendritic cells, and natural killer cells
  publication-title: J Exp Med
  doi: 10.1084/jem.185.9.1595
– volume: 8
  start-page: 266
  year: 2001
  ident: 2021122708262113200_b32
  article-title: Postmenopausal changes in production of type 1 and type 2 cytokines and the effects of hormone replacement therapy
  publication-title: Menopause
  doi: 10.1097/00042192-200107000-00008
– volume: 23
  start-page: 549
  year: 2011
  ident: 2021122708262113200_b12
  article-title: CD8+ T cell differentiation in the aging immune system: until the last clone standing
  publication-title: Curr Opin Immunol
  doi: 10.1016/j.coi.2011.05.002
– volume: 24
  start-page: 487
  year: 2011
  ident: 2021122708262113200_b8
  article-title: Regional immunity in melanoma: immunosuppressive changes precede nodal metastasis
  publication-title: Mod Pathol
  doi: 10.1038/modpathol.2010.227
– reference: 9151897 - J Exp Med. 1997 May 5;185(9):1595-604
– reference: 11564793 - J Immunol. 2001 Oct 1;167(7):3765-72
– reference: 19016906 - Immunology. 2009 Sep;128(1 Suppl):e325-34
– reference: 8170963 - Proc Natl Acad Sci U S A. 1994 Apr 26;91(9):3652-6
– reference: 14315085 - Exp Cell Res. 1965 Mar;37:614-36
– reference: 8977709 - Br J Dermatol. 1996 Dec;135(6):898-904
– reference: 12646667 - N Engl J Med. 2003 Mar 20;348(12):1104-11
– reference: 21664807 - Curr Opin Immunol. 2011 Aug;23(4):549-54
– reference: 11449084 - Menopause. 2001 Jul-Aug;8(4):266-73
– reference: 9794440 - J Immunol. 1998 Nov 1;161(9):5027-38
– reference: 17164077 - Maturitas. 2007 Apr 20;56(4):396-403
– reference: 11164458 - Mech Ageing Dev. 2000 Dec 20;121(1-3):37-46
– reference: 12954485 - Exp Gerontol. 2003 Sep;38(9):981-7
– reference: 8760829 - J Exp Med. 1996 Aug 1;184(2):747-52
– reference: 10927042 - Fertil Steril. 2000 Aug;74(2):261-7
– reference: 16136144 - Nature. 2005 Sep 1;437(7055):141-6
– reference: 21774806 - J Transl Med. 2011;9:113
– reference: 16516272 - Mech Ageing Dev. 2006 Jun;127(6):560-6
– reference: 20018825 - J Gerontol A Biol Sci Med Sci. 2010 Apr;65(4):429-33
– reference: 11772507 - Exp Gerontol. 2002 Jan-Mar;37(2-3):219-26
– reference: 10547158 - J Interferon Cytokine Res. 1999 Oct;19(10):1179-82
– reference: 17870272 - Exp Gerontol. 2008 Feb;43(2):61-5
– reference: 21151098 - Mod Pathol. 2011 Apr;24(4):487-94
– reference: 13905658 - Exp Cell Res. 1961 Dec;25:585-621
– reference: 8617297 - Eur J Immunol. 1996 Feb;26(2):315-9
– reference: 21150923 - J Invest Dermatol. 2011 Mar;131(3):719-26
– reference: 16618362 - Pediatr Allergy Immunol. 2006 Mar;17(2):125-33
– reference: 8690897 - J Immunol. 1996 Mar 15;156(6):2095-2103
– reference: 2052612 - Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5360-3
– reference: 8636260 - J Clin Endocrinol Metab. 1996 Feb;81(2):513-8
– reference: 22062437 - Clin Geriatr Med. 2011 Nov;27(4):491-506
– reference: 19240164 - Clin Cancer Res. 2009 Mar 15;15(6):1931-9
– reference: 10929062 - Immunology. 2000 Jul;100(3):384-90
– reference: 14760083 - Clin Cancer Res. 2004 Jan 15;10(2):610-4
– reference: 20536845 - Ann N Y Acad Sci. 2010 Jun;1197:158-65
SSID ssj0006662
Score 2.318087
Snippet Summary We have observed T helper type 2 (Th2) polarization of systemic immunity in patients with metastatic malignant melanoma. We hypothesized that similar...
We have observed T helper type 2 (Th2) polarization of systemic immunity in patients with metastatic malignant melanoma. We hypothesized that similar changes...
Summary We have observed T helper type 2 (Th2) polarization of systemic immunity in patients with metastatic malignant melanoma. We hypothesized that similar...
SourceID pubmedcentral
proquest
pubmed
pascalfrancis
crossref
wiley
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 186
SubjectTerms Adolescent
Adult
Aged
Aged, 80 and over
ageing
Aging
Aging - immunology
Aging - metabolism
Analytical, structural and metabolic biochemistry
Antigens
B-Lymphocyte Subsets - immunology
B-Lymphocyte Subsets - metabolism
Biological and medical sciences
CD3 Complex - immunology
CD3 Complex - metabolism
CD4 Antigens - immunology
CD4 Antigens - metabolism
CD40 Ligand - immunology
CD40 Ligand - metabolism
Chemokine CCL2 - immunology
Chemokine CCL2 - metabolism
Chemokine CCL5 - immunology
Chemokine CCL5 - metabolism
Cytokines - immunology
Cytokines - metabolism
Cytomegalovirus
Cytotoxicity
Fundamental and applied biological sciences. Psychology
Humans
immunity
Influenza
Lymphocytes
Male
MCP‐1
Melanoma
Melanoma - immunology
Melanoma - metabolism
Middle Aged
Original
Platelet-Derived Growth Factor - immunology
Platelet-Derived Growth Factor - metabolism
RANTES
Receptors, Immunologic - immunology
Receptors, Immunologic - metabolism
Receptors, Prostaglandin - immunology
Receptors, Prostaglandin - metabolism
Sex Factors
Skin cancer
T-Lymphocyte Subsets - immunology
T-Lymphocyte Subsets - metabolism
Th2 cells
Th2 Cells - immunology
Th2 Cells - metabolism
Young Adult
Title Normal ageing is associated with an increase in Th2 cells, MCP‐1 (CCL1) and RANTES (CCL5), with differences in sCD40L and PDGF‐AA between sexes
URI https://onlinelibrary.wiley.com/doi/abs/10.1111%2Fj.1365-2249.2012.04644.x
https://www.ncbi.nlm.nih.gov/pubmed/23039889
https://www.proquest.com/docview/1554497925
https://www.proquest.com/docview/1095454199
https://www.proquest.com/docview/1554943843
https://pubmed.ncbi.nlm.nih.gov/PMC3482365
Volume 170
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
link http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Ra9RAEF6kUBHEatUarccKPlhojttkk-w-HumdrbZHqVfoW9jNbujRkhZzB9Unf4LgP_SXOLPJpY0WKeJbyO4MyWT22293JzOEvC0CoRKVc38gjPA5CxJfSa38OFexsZGRIIXRFpN495h_OIlOmvgn_Bemzg_RbrjhyHB4jQNc6ao7yF2EFqwfMEIr6OMhHe8jn8QG5EdH15mkgKUHy6JqMEPyblDPrYo6M9XDS1WB0Yq62sVtdPTPqMqbbNdNV-M1crZ80TpK5ay_mOt-_vW3HJD_xxKPyaOG1dJh7YZPyD1brpPVus7ll3Vy_6A5wX9KfkyQJJ9TgDGYNOmsoqpxEGsobgpTVdJZiVy2snBBp6cBxdOFapsepIc_v31n9F2a7rMt6Gjo0XAyHX1yd6Kt7VrBsuYLICAqqNIdPth3vQ933o9Bw3BIm_A0WtkrWz0jx-PRNN31m8IQfg78k_sqD8H3Ass0LBaVlgqGA5N5bJMwF1ooo43mVhsr7aCwQNFMDAsnHlqA1EiERficrJQXpX1BaMJMApzSBMoUHPBOaMtVocPCyFAljHkkWTpBljdZ07F4x3l2Y_UE1s_Q-hlaP3PWz648wlrJyzpzyB1keh0_awWBtrq8PR7ZXDpe1oBNlSEl5DKRQeSRN20zwAR-HVXai0WFgQbAlTmT8i99QA9YSfDQIxu1L18_AFAdKQRIJx0vbztgmvJuSzk7denKMX0SvK1HYufEdzZGlo728Orlvwq-Ig_wdv3n6CZZmX9e2NdAIee6B-Cw97HnIOIX2OViNA
linkProvider Wiley-Blackwell
linkToHtml http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3da9RAEF-k4geIH7XaaK0r-GChOS7JXpJ9PNI7r3p3lHqFvi272Q09PNLS3EH1yT9B8D_0L3Fm89FGixTxLSQzQ3YyO_ub3ckMIW8zP5aRTJnbjXXsMs-PXMmVdMNUhtr0NAcuzLaYhqMj9uG4d1y1A8J_Ycr6EM2GG84M669xguOGdHuW2xQtCCAwRcvv4Ckd6wCgvI0Nvm18dXhZSwpwul-3VYM1krXTeq6V1FqrHpzJAtSWlf0urgOkf-ZVXsW7dsEaPiKLeqhlnsrnzmqpOunX36pA_iddPCYPK2BL-6UlPiG3TL5O7pStLr-sk7uT6hD_KfkxRZy8oODJYN2k84LKykaMprgvTGVO5znC2cLABZ2d-BQPGIpdOkkOfn777tF3STL2doBQ08P-dDb4ZO_0dnZLAXXbF3CCKKBI9lh3bKkP9t4PQUK_T6sMNVqYC1NskKPhYJaM3Ko3hJsCBGWuTAMwP994CuJFqbiEGeHxNDRRkMYqllppxYzShptuZgCl6RBiJxYY8Kq9OMiCZ2QtP83NJqGRpyOAldqXOmPg8mJlmMxUkGkeyMjzHBLVViDSqnA69u9YiCsBFGhfoPYFal9Y7YsLh3gN51lZPOQGPNstQ2sYAbna0j0O2aotT1T-phCIChmPuN9zyJvmMXgK_DoyN6erAnMNAC4zj_O_0IAc0FLMAoc8L4358gUA7fA4Bu6oZeYNAVYqbz_J5ye2YjlWUILROiS0VnxjZYhksI9XL_6V8TW5N5pNxmK8P_34ktxHkvJH0i2ytjxfmVeAKJdq23qKX4qOZVY
linkToPdf http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1fa9RAEF-kYhGkav0XrXUFHyw0xyXZJLuPR-7OVq_HUa_Qt2U3u6FHS3o0d1B98iMIfkM_iTP5c220SBHfQjIzJJPfzv42O5kh5F3mcxWrlLldbrjLPD92ldDKjVIVGRsaAVqYbTGO9o7Yx-PwuM5_wn9hqvoQqw9uODLKeI0DfG6y9iAvM7Rg_YAZWn4HN-lYB_jkXRZ1OSK8f3hVSgpout90VYMpkrWzem601JqqHsxVAV7LqnYXN_HRP9Mqr9Pdcr4aPiSnzZNWaSqnneVCd9KvvxWB_D-ueEQ2alpLexUOH5M7Nt8k96pGl182yfpBvYX_hPwYI0s-oxDHYNaks4KqGiHWUPwqTFVOZzmS2cLCAZ2e-BS3F4pdepBMfn777tH3STLydkDQ0MPeeDr4XJ4Jd3YrA03TFwiBaKBI-qw7KqUn_Q9DsNDr0To_jRb20hZPydFwME323LozhJsCAWWuSgMAn289DatFpYWC8eCJNLJxkHLNldFGM6uNFbabWeBoJoKVEwssxNSQB1nwjKzl57l9QWjsmRhIpfGVyRgEPK4tU5kOMiMCFXueQ-IGBDKty6Zj944zeW35BN6X6H2J3pel9-WlQ7yV5rwqHXILne0WzlaKwFvLwj0O2WqAJ-toU0jkhEzEwg8d8nZ1GeIEvh2V2_NlgZkGQJaZJ8RfZMAOeImzwCHPKyxf3QBwHcE5aMctlK8EsE55-0o-OynrlWP9JHhah0QliG_tDJkM9vHo5b8qviHrk_5QjvbHn16R-yhR_UW6RdYWF0v7GujkQm-XceIXGMdkDg
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Normal+ageing+is+associated+with+an+increase+in+Th2+cells%2C+MCP-1+%28CCL1%29+and+RANTES+%28CCL5%29%2C+with+differences+in+sCD40L+and+PDGF-AA+between+sexes&rft.jtitle=Clinical+and+experimental+immunology&rft.au=MANSFIELD%2C+A.+S&rft.au=NEVALA%2C+W.+K&rft.au=DRONCA%2C+R.+S&rft.au=LEONTOVICH%2C+A.+A&rft.date=2012-11-01&rft.pub=Blackwell&rft.issn=0009-9104&rft.volume=170&rft.issue=2&rft.spage=186&rft.epage=193&rft_id=info:doi/10.1111%2Fj.1365-2249.2012.04644.x&rft.externalDBID=n%2Fa&rft.externalDocID=26450388
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0009-9104&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0009-9104&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0009-9104&client=summon