Impaired natural killer cell‐induced antibody‐dependent cell‐mediated cytotoxicity is associated with human immunodeficiency virus‐1 disease progression

• Published in: Clinical and experimental immunology Vol. 171; no. 1; pp. 107 - 116
• Main Authors: Jia, M., Li, D., He, X., Zhao, Y., Peng, H., Ma, P., Hong, K., Liang, H., Shao, Y.
• Format: Journal Article
• Language: English
• Published: Oxford Blackwell 01.01.2013; Oxford University Press; Blackwell Science Inc
• Subjects: Adult; Analytical, structural and metabolic biochemistry; Antibody-Dependent Cell Cytotoxicity - genetics; Antibody-Dependent Cell Cytotoxicity - immunology; Antibody-dependent cell-mediated cytotoxicity; Asian Continental Ancestry Group - genetics; Biological and medical sciences; CD16 antigen; CD4 antigen; CD4 Lymphocyte Count; CD56 Antigen - analysis; CD56 Antigen - immunology; Disease Progression; Female; Flow cytometry; Fundamental and applied biological sciences. Psychology; Genotyping; GPI-Linked Proteins - analysis; GPI-Linked Proteins - immunology; Haplotypes; Histocompatibility antigen HLA; HIV Infections - genetics; HIV Infections - immunology; HIV-1 - immunology; HLA Antigens - genetics; HLA Antigens - immunology; Human immunodeficiency virus 1; human immunodeficiency virus type 1; human leucocyte antigen class I; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunodeficiency; Immunopathology; Infection; Infectious diseases; Killer Cells, Natural - immunology; Leukocytes; Male; Medical sciences; Middle Aged; Natural killer cells; NK Cell Lectin-Like Receptor Subfamily C - analysis; NK Cell Lectin-Like Receptor Subfamily C - immunology; NKG2 antigen; Original; receptors; Receptors, IgG - analysis; Receptors, IgG - immunology; Receptors, KIR2DL1 - analysis; Receptors, KIR2DL1 - immunology; Sex; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral Load - immunology; Immunopathology; HLA-System; Immune response; HIV-1 virus; receptors; antibody-dependent cell-mediated cytotoxicity; Retroviridae; AIDS; Biochemistry; Immune deficiency; Lentivirus; Infection; Virus; Natural killer cell; Associated virus; human immunodeficiency virus type 1; natural killer cells; Association; Viral disease; Antibody-dependent cell cytotoxicity; Human immunodeficiency virus; human leucocyte antigen class I; Biological receptor

Summary This study evaluates the correlation between natural killer (NK) cell function and human immunodeficiency virus (HIV)‐1 disease progression in 133 untreated HIV‐1 positive Chinese subjects, including 41 former plasma donors (FPDs) and 92 men who have sex with men, and 35 HIV‐negative control...