It's easier to get along with the quiet neighbours

Why are neighbouring genes co‐expressed at the RNA level? While it is tempting to think that this is to enable coordination of functionally related proteins, analysis of human proteomics data by Rappsilber and colleagues (Kustatscher et al , 2017 ) suggests this is the exception not the rule. Rather...

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Published inMolecular systems biology Vol. 13; no. 9; pp. 943 - n/a
Main Author Hurst, Laurence D
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 26.09.2017
EMBO Press
John Wiley and Sons Inc
Springer Nature
Subjects
EMBO09
EMBO17
Gene expression
News & Views
Proteins
Proteomics
Ribonucleic acid
RNA
Views
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Abstract Why are neighbouring genes co‐expressed at the RNA level? While it is tempting to think that this is to enable coordination of functionally related proteins, analysis of human proteomics data by Rappsilber and colleagues (Kustatscher et al , 2017 ) suggests this is the exception not the rule. Rather it might either be just something that happens or, in some instances, an epiphenomenon of coordination of expression to enable reduced gene expression noise. Graphical Abstract Why are neighbouring genes co‐expressed at the RNA level? While it is tempting to think that this enables protein‐level co‐expression, Rappsilber and colleagues (Kustatscher et al , 2017 ) report that it is the exception and not the rule. Instead, it might be related to the control of gene expression noise.
AbstractList Why are neighbouring genes co‐expressed at the RNA level? While it is tempting to think that this is to enable coordination of functionally related proteins, analysis of human proteomics data by Rappsilber and colleagues (Kustatscher et al , ) suggests this is the exception not the rule. Rather it might either be just something that happens or, in some instances, an epiphenomenon of coordination of expression to enable reduced gene expression noise.
Abstract Why are neighbouring genes co‐expressed at the RNA level? While it is tempting to think that this is to enable coordination of functionally related proteins, analysis of human proteomics data by Rappsilber and colleagues (Kustatscher et al, 2017) suggests this is the exception not the rule. Rather it might either be just something that happens or, in some instances, an epiphenomenon of coordination of expression to enable reduced gene expression noise.
Why are neighbouring genes co‐expressed at the RNA level? While it is tempting to think that this is to enable coordination of functionally related proteins, analysis of human proteomics data by Rappsilber and colleagues (Kustatscher et al , 2017 ) suggests this is the exception not the rule. Rather it might either be just something that happens or, in some instances, an epiphenomenon of coordination of expression to enable reduced gene expression noise. Graphical Abstract Why are neighbouring genes co‐expressed at the RNA level? While it is tempting to think that this enables protein‐level co‐expression, Rappsilber and colleagues (Kustatscher et al , 2017 ) report that it is the exception and not the rule. Instead, it might be related to the control of gene expression noise.
Why are neighbouring genes co‐expressed at the RNA level? While it is tempting to think that this is to enable coordination of functionally related proteins, analysis of human proteomics data by Rappsilber and colleagues (Kustatscher et al, ) suggests this is the exception not the rule. Rather it might either be just something that happens or, in some instances, an epiphenomenon of coordination of expression to enable reduced gene expression noise. Why are neighbouring genes co‐expressed at the RNA level? While it is tempting to think that this enables protein‐level co‐expression, Rappsilber and colleagues (Kustatscher et al, ) report that it is the exception and not the rule. Instead, it might be related to the control of gene expression noise.
Why are neighbouring genes co-expressed at the RNA level? While it is tempting to think that this is to enable coordination of functionally related proteins, analysis of human proteomics data by Rappsilber and colleagues (Kustatscher et al, ) suggests this is the exception not the rule. Rather it might either be just something that happens or, in some instances, an epiphenomenon of coordination of expression to enable reduced gene expression noise.
Why are neighbouring genes co‐expressed at the RNA level? While it is tempting to think that this is to enable coordination of functionally related proteins, analysis of human proteomics data by Rappsilber and colleagues (Kustatscher et al , 2017 ) suggests this is the exception not the rule. Rather it might either be just something that happens or, in some instances, an epiphenomenon of coordination of expression to enable reduced gene expression noise.
Author Hurst, Laurence D
AuthorAffiliation 1 The Milner Centre for Evolution Biology and Biochemistry University of Bath Bath UK
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10.1093/gbe/evr025
10.1038/ng887
10.1038/ng1111
10.1101/gr.1982804
10.1038/nrg1319
10.1016/j.cels.2016.03.009
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10.1093/nar/gku667
10.1371/journal.pbio.0040309
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28835372 - Mol Syst Biol. 2017 Aug 23;13(8):937. doi: 10.15252/msb.20177548
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Snippet Why are neighbouring genes co‐expressed at the RNA level? While it is tempting to think that this is to enable coordination of functionally related proteins,...
Why are neighbouring genes co‐expressed at the RNA level? While it is tempting to think that this is to enable coordination of functionally related proteins,...
Why are neighbouring genes co-expressed at the RNA level? While it is tempting to think that this is to enable coordination of functionally related proteins,...
Abstract Why are neighbouring genes co‐expressed at the RNA level? While it is tempting to think that this is to enable coordination of functionally related...
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Title It's easier to get along with the quiet neighbours
URI https://link.springer.com/article/10.15252/msb.20177961
https://onlinelibrary.wiley.com/doi/abs/10.15252%2Fmsb.20177961
https://www.ncbi.nlm.nih.gov/pubmed/28951503
https://www.proquest.com/docview/1943084536
https://www.proquest.com/docview/1943639488
https://pubmed.ncbi.nlm.nih.gov/PMC5615921
https://doaj.org/article/618f46fdb8ab4d10accf9ae7fd0c6409
Volume 13
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