It's easier to get along with the quiet neighbours

Why are neighbouring genes co‐expressed at the RNA level? While it is tempting to think that this is to enable coordination of functionally related proteins, analysis of human proteomics data by Rappsilber and colleagues (Kustatscher et al , 2017 ) suggests this is the exception not the rule. Rather...

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Bibliographic Details
Published inMolecular systems biology Vol. 13; no. 9; pp. 943 - n/a
Main Author Hurst, Laurence D
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 26.09.2017
EMBO Press
John Wiley and Sons Inc
Springer Nature
Subjects
EMBO09
EMBO17
Gene expression
News & Views
Proteins
Proteomics
Ribonucleic acid
RNA
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Summary:Why are neighbouring genes co‐expressed at the RNA level? While it is tempting to think that this is to enable coordination of functionally related proteins, analysis of human proteomics data by Rappsilber and colleagues (Kustatscher et al , 2017 ) suggests this is the exception not the rule. Rather it might either be just something that happens or, in some instances, an epiphenomenon of coordination of expression to enable reduced gene expression noise. Graphical Abstract Why are neighbouring genes co‐expressed at the RNA level? While it is tempting to think that this enables protein‐level co‐expression, Rappsilber and colleagues (Kustatscher et al , 2017 ) report that it is the exception and not the rule. Instead, it might be related to the control of gene expression noise.
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ISSN:1744-4292
1744-4292
DOI:10.15252/msb.20177961