CD4 + T cell targeting of human immunodeficiency virus type 1 (HIV-1) peptide sequences present in vivo during chronic, progressive HIV-1 disease
We previously detected HIV-1 Gag-specific CD4 + T cells recognizing reference strain viral epitopes in subjects with progressive, chronic infection. To test whether these CD4 + T cells persist in vivo by failing to recognize autologous HIV-1 epitopes, we compared autologous plasma HIV-1 p24 nucleoti...
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| Published in | Virology (New York, N.Y.) Vol. 361; no. 1; pp. 34 - 44 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
United States
Elsevier Inc
25.04.2007
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| Subjects | |
| Online Access | Get full text |
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| Abstract | We previously detected HIV-1 Gag-specific CD4
+ T cells recognizing reference strain viral epitopes in subjects with progressive, chronic infection. To test whether these CD4
+ T cells persist
in vivo by failing to recognize autologous HIV-1 epitopes, we compared autologous plasma HIV-1 p24 nucleotide sequences with targeted HXB.2 strain Gag p24 CD4
+ T cell epitopes in nine chronically infected, untreated subjects. In five responding subjects, 10 of 26 HXB.2 strain p24 peptides targeted by CD4
+ T cells exactly matched autologous plasma viral sequences. Four subjects with plasma viral loads >
100,000 copies/mL had no measurable p24-specific CD4
+ T cell responses despite carrying HIV-1 strains that matched HXB.2 sequences at predicted epitopes. These results show that HIV-1-specific CD4
+ T cells can persist in chronic HIV-1 infection despite recognition of epitopes present
in vivo. However, with high-level
in vivo HIV-1 replication, CD4
+ T cells targeting autologous HIV-1 may be non-responsive or absent. |
|---|---|
| AbstractList | We previously detected HIV-1 Gag-specific CD4+ T cells recognizing reference strain viral epitopes in subjects with progressive, chronic infection. To test whether these CD4+ T cells persist in vivo by failing to recognize autologous HIV-1 epitopes, we compared autologous plasma HIV-1 p24 nucleotide sequences with targeted HXB.2 strain Gag p24 CD4+ T cell epitopes in nine chronically infected, untreated subjects. In five responding subjects, 10 of 26 HXB.2 strain p24 peptides targeted by CD4+ T cells exactly matched autologous plasma viral sequences. Four subjects with plasma viral loads >100,000 copies/mL had no measurable p24-specific CD4+ T cell responses despite carrying HIV-1 strains that matched HXB.2 sequences at predicted epitopes. These results show that HIV-1-specific CD4+ T cells can persist in chronic HIV-1 infection despite recognition of epitopes present in vivo. However, with high-level in vivo HIV-1 replication, CD4+ T cells targeting autologous HIV-1 may be non-responsive or absent. Abstract We previously detected HIV-1 Gag-specific CD4+ T cells recognizing reference strain viral epitopes in subjects with progressive, chronic infection. To test whether these CD4+ T cells persist in vivo by failing to recognize autologous HIV-1 epitopes, we compared autologous plasma HIV-1 p24 nucleotide sequences with targeted HXB.2 strain Gag p24 CD4+ T cell epitopes in nine chronically infected, untreated subjects. In five responding subjects, 10 of 26 HXB.2 strain p24 peptides targeted by CD4+ T cells exactly matched autologous plasma viral sequences. Four subjects with plasma viral loads > 100,000 copies/mL had no measurable p24-specific CD4+ T cell responses despite carrying HIV-1 strains that matched HXB.2 sequences at predicted epitopes. These results show that HIV-1-specific CD4+ T cells can persist in chronic HIV-1 infection despite recognition of epitopes present in vivo . However, with high-level in vivo HIV-1 replication, CD4+ T cells targeting autologous HIV-1 may be non-responsive or absent. We previously detected HIV-1 Gag-specific CD4 + T cells recognizing reference strain viral epitopes in subjects with progressive, chronic infection. To test whether these CD4 + T cells persist in vivo by failing to recognize autologous HIV-1 epitopes, we compared autologous plasma HIV-1 p24 nucleotide sequences with targeted HXB.2 strain Gag p24 CD4 + T cell epitopes in nine chronically infected, untreated subjects. In five responding subjects, 10 of 26 HXB.2 strain p24 peptides targeted by CD4 + T cells exactly matched autologous plasma viral sequences. Four subjects with plasma viral loads > 100,000 copies/mL had no measurable p24-specific CD4 + T cell responses despite carrying HIV-1 strains that matched HXB.2 sequences at predicted epitopes. These results show that HIV-1-specific CD4 + T cells can persist in chronic HIV-1 infection despite recognition of epitopes present in vivo. However, with high-level in vivo HIV-1 replication, CD4 + T cells targeting autologous HIV-1 may be non-responsive or absent. We previously detected HIV-1 Gag-specific CD4+ T cells recognizing reference strain viral epitopes in subjects with progressive, chronic infection. To test whether these CD4+ T cells persist in vivo by failing to recognize autologous HIV-1 epitopes, we compared autologous plasma HIV-1 p24 nucleotide sequences with targeted HXB.2 strain Gag p24 CD4+ T cell epitopes in nine chronically infected, untreated subjects. In five responding subjects, 10 of 26 HXB.2 strain p24 peptides targeted by CD4+ T cells exactly matched autologous plasma viral sequences. Four subjects with plasma viral loads >100,000 copies/mL had no measurable p24-specific CD4+ T cell responses despite carrying HIV-1 strains that matched HXB.2 sequences at predicted epitopes. These results show that HIV-1-specific CD4+ T cells can persist in chronic HIV-1 infection despite recognition of epitopes present in vivo. However, with high-level in vivo HIV-1 replication, CD4+ T cells targeting autologous HIV-1 may be non-responsive or absent.We previously detected HIV-1 Gag-specific CD4+ T cells recognizing reference strain viral epitopes in subjects with progressive, chronic infection. To test whether these CD4+ T cells persist in vivo by failing to recognize autologous HIV-1 epitopes, we compared autologous plasma HIV-1 p24 nucleotide sequences with targeted HXB.2 strain Gag p24 CD4+ T cell epitopes in nine chronically infected, untreated subjects. In five responding subjects, 10 of 26 HXB.2 strain p24 peptides targeted by CD4+ T cells exactly matched autologous plasma viral sequences. Four subjects with plasma viral loads >100,000 copies/mL had no measurable p24-specific CD4+ T cell responses despite carrying HIV-1 strains that matched HXB.2 sequences at predicted epitopes. These results show that HIV-1-specific CD4+ T cells can persist in chronic HIV-1 infection despite recognition of epitopes present in vivo. However, with high-level in vivo HIV-1 replication, CD4+ T cells targeting autologous HIV-1 may be non-responsive or absent. We previously detected HIV-1 Gag-specific CD4 + T cells recognizing reference strain viral epitopes in subjects with progressive, chronic infection. To test whether these CD4 + T cells persist in vivo by failing to recognize autologous HIV-1 epitopes, we compared autologous plasma HIV-1 p24 nucleotide sequences with targeted HXB.2 strain Gag p24 CD4 + T cell epitopes in nine chronically-infected, untreated subjects. In five responding subjects, 10 of 26 HXB.2 strain p24 peptides targeted by CD4 + T cells exactly matched autologous plasma viral sequences. Four subjects with plasma viral loads >100,000 copies/mL had no measurable p24-specific CD4 + T cell responses despite carrying HIV-1 strains that matched HXB.2 sequences at predicted epitopes. These results show that HIV-1-specific CD4 + T cells can persist in chronic HIV-1 infection despite recognition of epitopes present in vivo . However, with high level in vivo HIV-1 replication, CD4 + T cells targeting autologous HIV-1 may be non-responsive or absent. |
| Author | Koeppe, John R. Wilson, Cara C. Boritz, Eli Rapaport, Eric L. Campbell, Thomas B. |
| AuthorAffiliation | b Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA c Department of Microbiology, University of Colorado Health Sciences Center, Denver, CO, USA a Department of Immunology, University of Colorado Health Sciences Center, Denver, CO, USA |
| AuthorAffiliation_xml | – name: a Department of Immunology, University of Colorado Health Sciences Center, Denver, CO, USA – name: b Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA – name: c Department of Microbiology, University of Colorado Health Sciences Center, Denver, CO, USA |
| Author_xml | – sequence: 1 givenname: Eli surname: Boritz fullname: Boritz, Eli email: eboritz1@jhmi.edu organization: Department of Immunology, University of Colorado Health Sciences Center, Denver, CO, USA – sequence: 2 givenname: Eric L. surname: Rapaport fullname: Rapaport, Eric L. organization: Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA – sequence: 3 givenname: Thomas B. surname: Campbell fullname: Campbell, Thomas B. organization: Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA – sequence: 4 givenname: John R. surname: Koeppe fullname: Koeppe, John R. organization: Department of Medicine, University of Colorado Health Sciences Center, Denver, CO, USA – sequence: 5 givenname: Cara C. surname: Wilson fullname: Wilson, Cara C. email: Cara.Wilson@UCHSC.edu organization: Department of Immunology, University of Colorado Health Sciences Center, Denver, CO, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/17169395$$D View this record in MEDLINE/PubMed |
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| Keywords | Mutations Human immunodeficiency virus type 1 CD4 + T cells Epitopes Gag protein |
| Language | English |
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| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Present address: Department of Medicine, Residency Program Office, 1830 East Monument Street/Suite 9020, Baltimore, MD 21287. Email: eboritz1@jhmi.edu |
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| Snippet | We previously detected HIV-1 Gag-specific CD4
+ T cells recognizing reference strain viral epitopes in subjects with progressive, chronic infection. To test... Abstract We previously detected HIV-1 Gag-specific CD4+ T cells recognizing reference strain viral epitopes in subjects with progressive, chronic infection. To... We previously detected HIV-1 Gag-specific CD4+ T cells recognizing reference strain viral epitopes in subjects with progressive, chronic infection. To test... We previously detected HIV-1 Gag-specific CD4 + T cells recognizing reference strain viral epitopes in subjects with progressive, chronic infection. To test... |
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| SubjectTerms | Amino Acid Sequence CD4 + T cells CD4 Lymphocyte Count CD4-Positive T-Lymphocytes - immunology Chronic Disease Disease Progression Epitopes Epitopes, T-Lymphocyte - genetics Fluorides Gag protein HIV Core Protein p24 - genetics HIV Core Protein p24 - immunology HIV Infections - diagnosis HIV Infections - immunology HIV Infections - virology HIV-1 - genetics HIV-1 - immunology HIV-1 - isolation & purification Human immunodeficiency virus type 1 Humans Infectious Disease Methacrylates Molecular Sequence Data Mutations Phylogeny Polyurethanes RNA, Viral T-Cell Antigen Receptor Specificity Viral Load |
| Title | CD4 + T cell targeting of human immunodeficiency virus type 1 (HIV-1) peptide sequences present in vivo during chronic, progressive HIV-1 disease |
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