Detrimental effects of glucocorticoids on neuronal migration during brain development

• Published in: Molecular psychiatry Vol. 14; no. 12; pp. 1119 - 1131
• Main Authors: Fukumoto, K, Morita, T, Mayanagi, T, Tanokashira, D, Yoshida, T, Sakai, A, Sobue, K
• Format: Journal Article
• Language: English
• Published: England Nature Publishing Group 01.12.2009
• Subjects: Actin; Age Factors; Amino acids; Animals; Animals, Newborn; Bromodeoxyuridine - metabolism; Calmodulin-Binding Proteins - genetics; Calmodulin-Binding Proteins - metabolism; Cell migration; Cell Movement - drug effects; Cell size; Cell Size - drug effects; Cells, Cultured; Cerebral cortex; Cerebral Cortex - cytology; Cerebral Cortex - drug effects; Cerebral Cortex - growth & development; Cerebral Cortex - pathology; Complications and side effects; Corticosteroids; Dexamethasone - pharmacology; Embryo, Mammalian; Embryonic Stem Cells - drug effects; Female; Gene Expression Profiling - methods; Gene Expression Regulation, Developmental - drug effects; Glucocorticoids; Glucocorticoids - pharmacology; Green Fluorescent Proteins - genetics; Health aspects; Humans; Hypothalamus; Medicine; Mental disorders; MicroRNAs; Microtubule-Associated Proteins - metabolism; Mimicry; Molecular modelling; Mutation; Myosin; Myosin Type II - genetics; Myosin Type II - metabolism; Nervous system diseases; Neurodevelopmental disorders; Neurons - drug effects; Neuropeptides - metabolism; Neurosciences; Oligonucleotide Array Sequence Analysis - methods; Pituitary; Plasmids; Pregnancy; Prenatal Exposure Delayed Effects - chemically induced; Prenatal Exposure Delayed Effects - pathology; Prenatal Exposure Delayed Effects - physiopathology; Rats; Risk factors; Thyroid gland; Time Factors; Transcription; Transfection - methods; Tubulin - metabolism; University graduates; Japan; United States > US

Glucocorticoids, the most downstream effectors of the hypothalamus-pituitary-adrenal axis, are one of main mediators of the stress reaction. Indeed, exposure to high levels of stress-triggered glucocorticoids is detrimental to brain development associated with abnormal behaviors in experimental anim...