Influence of long-term caloric restriction on myocardial and cardiomyocyte contractile function and autophagy in mice

• Published in: The Journal of nutritional biochemistry Vol. 23; no. 12; pp. 1592 - 1599
• Main Authors: Han, Xuefeng, Turdi, Subat, Hu, Nan, Guo, Rui, Zhang, Yingmei, Ren, Jun
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.12.2012; Elsevier
• Subjects: Acetyl-CoA Carboxylase; Acetyl-CoA Carboxylase - metabolism; ad libitum feeding; AMP-Activated Protein Kinase Kinases; anatomy & histology; Animals; Autophagy; Autophagy - physiology; Biological and medical sciences; Body Weight; Caloric Restriction; Calorie restriction; Cardiac function; cardiomyocytes; Cell Size; cytology; Echocardiography; Feeding. Feeding behavior; Fundamental and applied biological sciences. Psychology; glucose; Glucose Tolerance Test; Heart; Heart - anatomy & histology; Heart Ventricles; Heart Ventricles - anatomy & histology; Insulin signaling; JNK Mitogen-Activated Protein Kinases; JNK Mitogen-Activated Protein Kinases - metabolism; Male; metabolism; Mice; Mice, Inbred C57BL; Myocardial Contraction; Myocardial Contraction - physiology; Myocardium; Myocardium - metabolism; Myocytes, Cardiac; Myocytes, Cardiac - cytology; Myocytes, Cardiac - physiology; obesity; Organ Size; Phosphorylation; physiology; protein kinases; Protein Kinases - metabolism; Proto-Oncogene Proteins c-akt; Proto-Oncogene Proteins c-akt - metabolism; Remodeling; Signal Transduction; TOR Serine-Threonine Kinases; TOR Serine-Threonine Kinases - metabolism; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Western blotting; Remodeling; Autophagy; Cardiac function; Calorie restriction; Insulin signaling; Calorie; Heart; Pancreatic hormone; Rodentia; Insulin; Long term; Signal transduction; Vertebrata; Mammalia; Mouse; Animal; Myocardium; Circulatory system; Heart cell

Both clinical and experimental evidence has revealed that calorie restriction (CR) is capable of improving heart function. However, most the reports are focused on the effect of CR on the pathological states such as obesity, while the effect of CR on heart function in otherwise healthy subjects is n...