Progeny of Olig2-Expressing Progenitors in the Gray and White Matter of the Adult Mouse Cerebral Cortex

• Published in: The Journal of neuroscience Vol. 28; no. 41; pp. 10434 - 10442
• Main Authors: Dimou, Leda, Simon, Christiane, Kirchhoff, Frank, Takebayashi, Hirohide, Gotz, Magdalena
• Format: Journal Article
• Language: English
• Published: United States Soc Neuroscience 08.10.2008; Society for Neuroscience
• Subjects: Animals; Animals, Genetically Modified; Antigens - metabolism; Basic Helix-Loop-Helix Transcription Factors - genetics; Basic Helix-Loop-Helix Transcription Factors - metabolism; Cell Differentiation; Cell Proliferation; Cerebral Cortex - cytology; Gene Expression; Genes, Reporter; Integrases; Mice; Mice, Inbred C57BL; Mitosis; Myelin Sheath - ultrastructure; Nerve Tissue Proteins - genetics; Nerve Tissue Proteins - metabolism; Neuroglia - cytology; Neuroglia - metabolism; Neuroglia - pathology; Oligodendrocyte Transcription Factor 2; Oligodendroglia - cytology; Oligodendroglia - ultrastructure; Periaqueductal Gray - cytology; Proteoglycans - metabolism; Stem Cells - cytology; Stem Cells - metabolism; Tamoxifen - pharmacology; Wounds, Stab - pathology

Despite their abundance, still little is known about the rather frequent, constantly proliferating progenitors spread throughout the adult mouse brain parenchyma. The majority of these progenitors express the basic-helix-loop-helix transcription factor Olig2, and their number further increases after...