Unlocking the secrets: the power of methylation-based cfDNA detection of tissue damage in organ systems

• Published in: Clinical epigenetics Vol. 15; no. 1; pp. 168 - 20
• Main Authors: Zhang, Lijing, Li, Jinming
• Format: Journal Article
• Language: English
• Published: Germany BioMed Central Ltd 19.10.2023; BioMed Central; BMC
• Subjects: B cells; Biomarkers; Biomarkers, Tumor - genetics; Biopsy; Cell differentiation; Cell division; Cell-Free Nucleic Acids - genetics; cfDNA; Clinical trials; Cytokines; Development and progression; Disease; Disease Progression; DNA; DNA damage; DNA Methylation; DNA repair; Enzymes; Epigenesis, Genetic; Epigenetic inheritance; Epigenetics; Gene expression; Genomes; Humans; Inflammation; Methylation; Oxidative stress; Review; Reviews; Signal transduction; Technology application; Tissue and organ damage; Transplantation; Tissue and organ damage; Biomarkers; Methylation; cfDNA

Detecting organ and tissue damage is essential for early diagnosis, treatment decisions, and monitoring disease progression. Methylation-based assays offer a promising approach, as DNA methylation patterns can change in response to tissue damage. These assays have potential applications in early det...